I did one a few years ago with the kids but we ventured out of Cali a bit. We did -
LA - stayed in Burbank area, wasn't interested in Disney but did Warner Bros which we loved and also Universal, visited Beverley Hills, Santa Monica etc
Las Vegas - stayed at the Bellagio, kids loved Vegas, so much to do. We're not gamblers so didn't bother with that. Neon Museum was great, but go at night. From here we also went to Hoover Dam and Grand Canyon South Rim. A lot further drive, but doable as a day trip and we took in old Route 66 which was great.
Death Valley - so hot and the warm spring pool at night was fantastic, could see the Milky Way.
Stopped at Lee Vining and went to Bodie ghost town. Was meant to be at Yosemite but the whole place was basically burning down so had to avoid it, the roads were closed. Gutted about that!
San Francisco - Loved it, can't remember the name of the hotel but it was in Fisherman's Wharf - Alcatraz night tour was great but book well in advance.
Carmel - used this as a base and went to Monterary for whale watching trip etc.
Santa Barbara - Just loved it here, beautiful chilled but lively place to end the trip!