there's the wiggin tree, parbold. its a brewers fayre so food, not fantastic but its large, serves all day and easy to find. come off a junction 27, head towards parbold, and before you get to the village, its on the right, on the top of parbold hill. you get a great view all the way from north wales to blackpool from the hill (we used to live in parbold until last july)
further south, off junction 22, there's more of a gastro pub. the swan at winwick, this is a chef & brewer place. food much nicer. come off m6 at junction 22, head towards warrington on the a49, at roundabout, turn right to winwick, pub is just there on the right. also serves all day.
if you are just looking for somewhere to pull off the motorway and get sorted rather than have a break and eat. at junction 27, there is a bp garage off the roundabout, and also one at the junction with the a580, i think its junction 23. both involve coming off the motorway and you can get back on going in either direction.
hth