We have been to Gascony twice, right on the Spanish border on the Atlantic side,and we went Dover/Calais with overnight stop in Tours. Arrived about 4pm on next day.
Have also been to the Med, & Spain, again with overnight stop in Novotel.
This year we are going to Perpignon and will stop in Bourges for one night (always in Novotels).
My DH would rather drive than spend hours in an airport. Plus it's cheaper, you can take so much more luggage and have your car to fill up with wine on the way home.
We have been as far as Charente Maritime in a day, but we live in Berks so not too far to get to the ports.