Roaccutane. It cured 2 very very nasty bouts of adult acne, a few years apart. Ever since the 2nd lot almost 4 years ago, my skin is absolutely perfect. Seriously, about 1 spot every 6 months, and the rest of the time my skintone is good, even, blemish-free.
It cost a lot of money, probably close to four hundred or five hundred quid, for dermatologist appointment and prescriptions. But my God, it was worth every penny. I would otherwise have spent more than I could afford on lotions and potions, and the misery it was making my life was just not worth worrying about the money. I think it can be available on NHS for some cases, but couldn't be sure.
Side effects were not at all bad for me, and certainly better than the awful, painful, red pustules I was living with before!! Dry eyes, yes, and dry lips, but nothing horrendous. You can't take it if you are trying to get pregnant. It is strong stuff. But EVERYTHING else I had tried, from alternative cures to topical lotions prescribed by GP etc, had NO effect on me at all.
There were reports a few years back about it being linked to depression and a couple of teenagers allegedly committed suicide while on drug. I can't possibly comment on the studies of course, all I can say is what my dermatologist said to me (she was a very sensible mother of three teenage kids) - that in her experience, there are far more teenagers who are depressed and suicidal as a result of horrendous skin and/or bullying because of that. All she advised me to do, seeing as I had had a history of depression, was to warn my nearest and dearest to alert me if they saw any changes in me, and she asked me about it at my monthly appointments. Needless to say, I could not have been LESS depressed that my skin was clearing up!
Good luck becstar and bunnybumblesmum, I am sure you will find the thing that works for you. Roaccutane was my last resort, I wish I had found another way so I could tell you about that too, but it really was worth every penny I spent. I know how horrible it is to go around with a face you are trying to hide, especially when you are not a teenager anymore. Very best of luck! Hope this has helped.