Mounjaro? Menopause? Hypertonic pelvic floor, Fibro? Hypermobility

[FlorenceB19]

Looking for experiences to explain numerous health symptoms.

For reference... I'm 51 & 4 years post menopause. Been on Mounjaro for 12 months, HRT 3 yrs, antidepressants for 27 yrs & diagnosed with fibro overlapping CFS approx 30 years ago. Moderate fatty liver (through medication use)

SW 12.7
CW 10.1
GW 9.7

However, since March I've experienced numerous new issues mainly affecting my muscles, causing constant overactive muscles (always feeling tense/or spasms internally) yet muscle tone weakness.

This has caused a diagnosis of hip bursitis, gluteal tendinitis, anal sphincter spasms resulting in painful haemorrhoids & anal fissures. (Possible hypertonic pelvic floor) A MRI shows degenerative disc disease within lower spine.

I have an anterior pelvic tilt and my knees hyperextends backwards which exasperates the tilted hips & pelvis forward. (Always been bendy with stretchy skin,yet never considered hyper mobility until recently) 🤷🏽‍♀️

My question is what reasons relates to these symptoms?

Is it Mounjaro? Also causing HRT to decrease effectiveness?
Is it just menopause?
Is it fibro?
Is it hyper mobility?
Is it hypertonic pelvic floor?
Or could it be something else?
Or just interlinked?

Has anyone else experienced similar issues & what has helped?

I have a severe case of Ehlers Danlos syndrome, thoracic outlet syndrome and neurofibromatosis. I am about your age. If you look up the Beighton scale and do those movements in the mirror, or in front of someone observing then you can figure out if you are hypermobile. I score 8 out of 9. There is a more extensive test screener for Ehlers Danlos syndrome on the internet. It is a series of questions about your life and history that can be quite revealing, and you can take it to the GP. I am quite severely disabled from a cluster of very rare conditions that all cause joint pain, skin issues and significant neuropathy. Menopause made it worse. I was diagnosed with sarcoma, which was due to a genetic defect. It turns out the defect is a matter of chromosome translocation. I wonder if my Ehlers Danlos and other conditions are all due to the same pattern of genetic defect. I have duplicate organs (two wombs) or overly large organs (bowel and bladder three times too big), for example. The latter was discovered when I had a rectal prolapse requiring surgery. I have polycystic ovaries and thyroid underactivity. If you believe you are hypermobile, it is important to be formally diagnosed and have it recorded in your medical notes. I was mid-40s by the time I was diagnosed and it was too late to stop some of the awful damage it has done to my joints and nerves. There are indications of neurological damage as well. It would be a good idea to have some blood tests run to see how you are doing metabolically, as there maybe clues there. I hope you get some answers and feel better soon.