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Statins.

9 replies

KB363736383729382 · 29/09/2024 20:07

33 year old female. Non smoker, non drinker, diet not the best (but I wouldn’t say the worst either) and could do with losing a couple stone. Have a lot of stressors in my life.

Quite a few months ago I had my cholesterol checked and it was above optimal levels and was told to make lifestyle changes. My Qrisk is low at 0.4%. However, here comes the problem. They also tested something called lipoprotein A, which is purely genetic and doesn’t usually change with diet or even statins. This isn’t always tested for but I have done family history of heart disease and one of my children were being tested for FH (now come back negative).

anyway, statins has been recommended based on the fact it will reduce my overall risk particularly with the high Lp (a).

I am scared of taking them. Scared of side effects, scared of being on them for life, scared they will make things worse for me, when right now I am very healthy. I also almost feel embarrassed that I will be on them at a young age as most people on them are older.

anyone else been on statins? Particularly those starting in their 30s?

some family history. Don’t know too much about paternal side but on my maternal side my grandfather has quite strong family history, he had his first HA at 50, my uncle died suddenly age 55 and one of the factors in his death was heart related, clogged arteries and his post portem showed a historical silent heart attack (but he had a lot of health issues going on and there was other factors including sepsis, diabetes and other things). Further back there is history on my grandfathers side, my mum is in her fifties and on statins herself.

any advice ?

OP posts:
DevilledEggsies · 29/09/2024 21:27

I’m in my 50s and on a maximum dose statin which helps to keep my LDL down to around 7 (which is according ot many doctors still high). I have LP(a) but not a lot of it (around the low end of the normal range actually so LP(a) is not my problem).

The problem you are faced with is that statins will not actually help with LP(a). LP(a) is the LDL variant that the liver cannot re-cycle/re-use, so this small LDL particle builds up over time. Even if you body makes less LDL it will still build up. So reducing the amount of LDL your body makes will not meaningfully reduce your LP(a) - if that is the concern.

What you need instead is a PCSK9 inhibitor - but I suspect they will be reluctant to give a 30 year old this as it will most likely require regular injections and is much more costly than a statin. A PCSK9 inhibitor works by helping to improve the recycling of LP(a) particles via a greater number of receptors.

If you have very high LP(a) then you will need apheresis.

You could also try Niacin (a type of vitamin b3) - but make sure it is the flush type. The non-flush type do not work. Niacin is what they used to use before statins were invented - but many people don’t like the side-effect (the flush) of Niacin - and to be honest one does need to build up their tolerance of it. I got to quite like it when I used it (for plaque stabilisation/reduction), but you need 1g a day really.

I don’t believe I have had any side effects from the statins, but my father in law who took them shortly whilst in his 70s had awful side-effects (leg pains) so stopped taking them and most likely due to being a type 1 diabetic ended up with a heart bypass op and then a series of strokes. You won’t know if you will have side effects until you try them.

My LDL is all the large healthy pattern of LDL, not the small dangerous LDL so my risk is now low despite the LDL score of 7 - that is if a more “current” or upto date doctor sees my blood profile. A high LDL score is not bad if the particle size is not small - it’s the small particles that can contribute to unstable plaque which in turn result in rupture and blood clots.

The main benefit of statins isn’t really the cholesterol lowering feature, as studies have shown that statins do not reduce heart attacks or make people live longer - and 25% of all people having heart attacks have low cholesterol anyway. Well let me just clarify that a little, the largest ever study of it’s kind in this area did show an all-cause mortality benefit to statins in one cohort, but only one cohort - ladies over the age of 80.

The main benefit of statins is reduction of inflammation, especially cardio-vascular inflammation. That is the reason the upto date doctors prescribe statins, not for cholesterol. Reduced inflammation is also one tool to turn unstable dangerous plaque into stable plaque. Stable plaque does not result in blood clots or heart attacks.

At your age I would get a full set of lipid tests, including an LDL-p test where they measure the particle size. Sometimes they call this an LDL subfraction test but you are unlikely to get this on our out of date NHS. Other more modern countries like Australia do this as a matter of course. I got mine done at a private london clinic via healthily.co.uk

As for heart attacks, they’re caused by clots of course, so taking a low dose aspirin might be more preventative but I don’t think they reccommend it for secondary prevention nowadays so you would do better to reduce your carb intake to lower your blood sugar levels & insulin spikes, and look after your blood pressure to protect your arterial walls. Losing weight will help massively to keep your blood pressure down which in turn reduces stress on your endothelium.

AlwaysQuestions · 30/09/2024 13:50

Have you watched this video by Heart UK? It is quite long but might help your decision. There is also quite comprehensive information on that page regarding Lp(a).
https://www.heartuk.org.uk/genetic-conditions/high-lipoproteina
In answer to taking statins at a young age, yes, I started taking them at your age due to FH. I was actually recommended to take them in my mid 20s but like you I had all the same reservations as you and I somewhat delayed several years - which I now kind of regret! I have taken them for over 20 years now. Please don't feel embarrassed to take statins, people are born with these genetic conditions, it's not something they can help! As for side effects, if you get any you can change to a different type of statin. Millions of people take them and have no side effects. I don't even know if I also have high LP(a) - would imagine that I probably do, maybe it depends what area you live in whether this is tested for - thank you for bringing up this topic as I will ask my doctor about getting tested. It's scary getting any health problem diagnosed but at least knowing about it early on means you can work on modifiable risk factors such as healthy eating, exercise, losing weight etc. I would say discuss your fears with your Dr or lipid specialist and be guided by them.

High lipoprotein(a)

Lipoprotein (a), or LP(a) for short, is a large lipoprotein made by the liver. It’s similar to LDL cholesterol but more ‘sticky’, and high levels in the blood are a known risk factor for heart disease. Learn about its diagnosis and treatment.

https://www.heartuk.org.uk/genetic-conditions/high-lipoproteina

olderbutwiser · 30/09/2024 14:04

I’ve recently started statins and have had no side effects at all.

DevilledEggsies · 30/09/2024 19:07

One more thing you could also try is Berberine which is known to be anti-inflammatory, lowers blood sugar, is an antioxidant, lowers cholesterol (PCSK9 inhibition) and hinders clotting.

I also want to again highlight not underestimating the effect of blood pressure as high blood pressure directly drives arterial plaque build-up. The youtube videos by Physionic are worth watching r.e. atherosclerosis and plaque build-up.

damekindness · 30/09/2024 20:13

I started Statins 6 months ago and have not had one side effect. It effectively slashed my cholesterol and triglycerides to the lower side of normal. I'm quite evangelical about the benefits of statins - the evidence base for them is excellent.

KB363736383729382 · 30/09/2024 20:33

Thanks guys 🌸🌸

my Lp (a) is 1017mg/l

quite often online it’s referred to in mmol/L so it’s all confusing

literally been told lifestyle changes and statins. Nothing else offered. Lipid clinic won’t see me.

I didn’t meet the criteria for being tested for FH, but my son did (in his case it was looking more likely to be genetic on his father’s side but his test came back negative). His LP (a) is on the top end of normal but an acceptable range luckily!

OP posts:
KB363736383729382 · 30/09/2024 20:34

Thankfully my blood pressure is better than it ever has been. It’s never been high as such. My Systolic was always great but used to have issues with my diastolic running in the 90s.

OP posts:
KB363736383729382 · 30/09/2024 20:36

I also had other tests such as for diabetes, Apo B, inflammation markers, liver, kidney etc and all results were well within the normal range so not a concern so it’s just trying to eat healthier, losing weight and starting statins I guess!

OP posts:
automaticallygenerated · 10/02/2025 13:45

@DevilledEggsies just wondering why you need to take statins if your LDL is all the large fluffy non problematic healthy kind? I’m curious to know because I’m currently being tested to see what mine is because I have high HDL and low triglycerides as well as higher LDL (3.8) which I’m led to believe is indicative of having a higher likelihood of the large fluffy type rather than the small dense type. I really don’t want to take a statin and I will do all I can to avoid them.

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