Is it better to split thyroxine or take it all in the morning?

[KatyMac]

Subclinical hypothyroidism diagnosed in Nov started on 25mcg moved to 50 in Feb

I have to take 2 x 25 mcg of wockhardt levothyroxine as I had a bad reaction to 50 Mercury

Someone, can't remember who said take one morning and one evening and I was them someone else said no take it all in the morning

Which is better or does it not matter

Oh my mistake! 😳That'll teach me to reply early in the morning! Sorry yes of course she is also splitting the dose during the day. That's the first time I've heard of someone doing that, however some folks are very reactive to Levo. As they say, everyone is different.

I don’t know if there’s a correlation between build and thyroxine dose but I’m v short.
i had started in 150mcg but it affected my sleep badly.
200mcg is the most I’ve heard friends/ family take.

As my post said, I am also splitting the dose by taking one pill in the morning and the second before I go to bed. So I'm alternating days, and splitting each dose daily.

@CrunchyCarrot just saw your last post 🙈. I'm am VERY reactive to thyroxine, can only tolerate wockhardt brand and splitting works generally. Although after reading this post, I'm tempted to experiment with taking it all together again as I wonder if its part of the reason why I don't sleep great.

It's unlucky you are so reactive, maybe it's one of the excipients rather than thyroxine itself? Poor sleep is often part and parcel of hypothyroidism, though. Waking at 2-3 a.m. then unable to get off again or waking many times during the night.

My own experience of hypothyroid medication has been one of experimentation! It can be very frustrating indeed. I do sleep better now but that's down to taking vitamin B2 and B12, that made a big difference. However I never get the refreshing sleep I used to get.

That’s exactly how I feel about thyroxine re lack of refreshing sleep. I sometimes think when I’m on my way out of this world I will stop taking thyroxine so I can enjoy refreshing sleep again!

It's not thyroxine that causes unrefreshing sleep, it's lack of active thyroid hormone. Going without it altogether would not help I'm afraid, quite the reverse!

This and do not take with other medications either. A sip of water first thing in the morning with it.

First thing in the morning with lanzaporole - I queried this after reading somewhere they shouldn't be taken together and was told it's perfectly fine

I take mine at night just before bed and my bloods are perfect. I've been on it since 2016.

It's really not perfectly fine. Lanzoprazole lowers stomach acid and you need that to absorb Levothyroxine. I wouldn't take them together.