I'm sure there's people on here who know far more than me about this. I'm on Thyroxine as I don't have a working thyroid ( fried by radiotherapy a few years ago after a tongue tumour). Before I was diagnosed I'd lost 4.5 stone as a result of my treatment and was struggling to gain weight - I got far to thin far too fast. Once the doctor did a blood test I was put onto 100mcg of thyroxine and have been on that since and have put on at least 3 stone. Last blood test in August the doc reduced my dose to 75mcg as she said my level was 14 and should be below12. Trouble is I don't feel as well as I did on 100mcg. I seem to be putting on more weight and have low level constant anxiety that I've never had before (though there is work crap going on in the background that could be contributing, but I have never ever had this constant worry feeling before when stressed and I'm 62 so I'd have thought I would have). My doctor is pretty difficult to talk to. I know her attitude will be "I've told you to reduce it to 75mcg so do it". What will the effect be if I continue to take 100 ? Or should I do 100 one day and 75 the next ? I really don't understand how this stuff works !! Thanks