Is pernicious anaemia hereditary?

[ncge]

DM has pernicious anaemia and another sort (wrong shaped RBCs) , she was diagnosed at around 21/22 years old and has been having B12 jabs for years .

My gran is the same and also gets the jabs.

Afaik my great gran also had issues like it . Her father died of stomach cancer too ...

Mum has numbness to fingers and toes, lost most of her teeth over time, really crap memory/brain fog and exhaustion . She’s been on and off iron and stuff for years too .

I have had weird symptoms for ages - worsening over a few years - fatigue, total loss of balance (struggle to walk on a bad day, can’t stand upright without holding onto something), pain in my mouth, just generally feeling crap 24/7 . I have MH issues so I’ve just put it down to that and being v overweight . DM has suggested I possibly have the same anaemia though we have no idea if it’s hereditary . DM thinks she was told it was passed onto female relatives but that was in 1989 when they probably knew less ...

Is it worth asking for B12 bloods to be done ? DM gets zero benefit from her injections now unfortunately ... my gran says they help her though . I’m sure B12 can make you properly ill if left can’t it ?

Yes to all of the above. I'm no expert but many females in my family get b12 injections and recently my Dr has given them to me. My b 12 is low but I don't actually have pernicious anemia from the results of blood tests. Although Dr. said I might still need the b 12.

It’s usually caused by autoimmune disease, so yes it can run in families (as with yours) but It’s not directly inherited though, more increased tendency. Yes, go and see your Gp and discuss having your B12 and folate checked. Good luck.

Yes it can be. Get your vitamin d checked too.

It's worth having a look at the Pernicious Anaemia website and having some information behind you before you see your Doctor. Your Mum should be looking at it too if she feels her injections are no help. Perhaps, she needs them more frequently?