Hi Trampire ,
I wonder if you have considered the following, it may be an avenue to explore. I'm so sorry to hear of your predicament.
Your mention of dovobet, the calcipotriol it contains, as well as its' effectiveness in a close genetic relative may mean that you yourself may very well respond to the Vitamin D hormone (1.25 dihydroxyD3). You may not know , but calcipotriol works by triggering the vit d receptor in skin cells. It is a very close chemical analogue.
A number of years ago , a vitamin D researcher, Prof. Holick found that vit d hormone , when applied to the skin dramatically reduced psoriasis , this discovery enabled the pharma companies to develop calcipotriol. A great deal of investigation has been done on the relationship between Vit D , and psoriasis. It seems that Vit D can often prove to be helpful for many people. Here is a site which collates those researchers findings . you may find it interesting to view. <a class="break-all" href="https://vitamindwiki.com/Psoriasis" rel="nofollow" target="_blank">vitamindwiki.com/Psoriasis</a>
It may be useful for you, to enable your body , to make that hormone , naturally, so allowing your skin cells to take it up from the Vitamin D3 that diffuses through your body.
Most people in this country, UK, are low in their vitamin D levels. It is an essential micronutrient. It up and down regulates about 2000 of our genes. Almost every cell in our body , has a Vitamin D receptor, including skin cells. Inflammation and immune system function are known to be responsive to Vit D hormone. It may well be advantageous for you to ensure you have enough, i.e. a sufficient level. In the UK ,we are likely to have levels around 30 to 70. these blood levels are much below those that prevailed , throughout our evolutionary history. That would be 120 - 140 nmol/L
Human physiology is such that whenever our blood levels are below 100 , then Vit D3 , from sunlight on our skin or from our food is rapidly converted to a form ( 25hydroxyD3) that is not so readily available to most of our cells. However when our blood level exceeds 100 , then Vit D3 is much more available to be converted to Vit D hormone ( 1,25 dihydroxyD3) for other cells , including skin cells.
Perhaps this may be a rather convoluted way of saying that if you had a "good" level of vitamin D3 , then you may well improve your situation. The "good" level that you require will be over 100 , preferably at least 120 - 140 nmol/L .
If you maintain that blood level, then your skin cells will have it available to them, if they require it. i.e. if an individual skin cell needs vit D to switch a gene on or off , it will be there. Vitamin D becomes a nuclear seco-steroid hormone .
The levels I am suggesting are to be found in humans , living an old fashioned lifestyle, i.e. outdoors in sunshine quite a bit. Here in the UK, we can't manage that , its too cold .. ! Also sunlight is too weak for 6 months of the year to make vitamin D in our skin. Our only real option is to supplement , or use a sunbed with some UVB . Not as powerful as the UV treatment lamps that are used in hospitals for psoriasis etc.
IF you were considering this Vitamin D enhancement option , as I am suggesting, then you could either ask your doctor to measure your vitamin D level, OR you could get a home test from this NHS lab. It is probably the biggest Vit D lab in the country. IF the test is not doctor ordered they do charge £29 unfortunately. <a class="break-all" href="http://www.vitamindtest.org.uk/" rel="nofollow" target="_blank">www.vitamindtest.org.uk/</a>
When you have obtained a figure from the test , lets say 50 , then in order to raise your vitamin D level, you most likely will need ongoing daily supplementation of 1000 IU in order to raise your blood level by each 25 nmol/L . If your level was 50 , then by taking 3000 IU per day , ongoing , as a daily supplementation , you could raise your level to roughly 120 -125. we all have different responses. You may be more , you may be less... have a further vitamin D blood test after approximately 3 months , when your blood level will have stabilised , on any particular daily dose. Then adjust your dose , if necessary to keep it around the 120 - 140 mark. After quite a few months , your body will have the parent compound Vit D3 available to your psoriatic cells , you may very well find things improve. Whilst there is no guarantee... it is probably worth trying and may very well do what you want.
Vitamin D is very cheap to buy , and is generally a very safe supplement. Try and get a pure form of Vitamin D3 , preferably in an oil based capsule. Often available online, or indeed from your doctor ...if he is supportive. Daily supplementation is much the most preferable, weekly high doses or even monthly bolus doses , are not as useful.
I have posted quite a bit about vit D on here on Mumsnet, have a look at those threads for a lot more information . OR , get back to me if you need any other info.
Phew... a long post ...
maybe it will be helpful to you.
Best of luck
BTBH
PS. 120 to 140 is considered to be within the normal band of vitamin D levels by our NHS. Commonly they will say that from 50 to 180 is acceptable. To be around 50 or even below , is not a good place to be.