Hi Visions
It is good that you now know your level of 25hydroxyD3. At 73 nmol/L roughly a month after the end of summer , it is probably higher than 50% of the UK population right now. , however , it is still lower than recommended by many vit D researchers.
In the light of your Fibromyalgia diagnosis it makes a great deal of sense to raise your levels to at least 120 - 140 , even higher ,possibly even up to 200 , would not be a concern . You are trying to recover from a particular health issue. Natural levels in outdoor workers etc can reach 200. Although I would say that you would then be using vit D in a pharmacological way , and if you proceed with significantly higher doses or blood levels you should check your Calcium level. If it is outside the normal range , then take the appropriate action. This would be very unlikely , but it is prudent to check.
Vitamin D enables you to REGULATE the amount of calcium you absorb from your food to your precise needs. It does not cause you to absorb more calcium than you need. That is a very important point. Massive overdoses ( i.e. many tens of thousands of IU daily ), over many months could in some circumstances overwhelm the regulatory function.
Yes ...in your situation I would increase your daily dose up to 5000 or 6000 IU , which may be eminently suitable to achieve that level raising effect that you need. ( Although it is quite likely to have the effect you want ... whether or not it does, depends upon your own particular physiology. ) You know your present vitamin D dose is definately having some effect , albeit somewhat less than you might have expected. The reasons for this can be varied .....are you a smoker ? is your vitamin d binding protein less efficient (VDBP)... is your digestion of fats less efficient than normal, etc etc. total weight ?, and so on.
If you are able to finance that spray you mentioned, then yes , it is quite a good idea to use it... you would be eliminating quite a few possible causes of low response. In fact we don't know every single reason why some of us seem to respond less.
Many other people reading this thread most likely will not need to spend greater amounts on more expensive supplements . Most peoples needs can be supplied by using approx £ 15 per year supplements of Vit D. ie.gel capsules.
In my opinion , you should change now to an increased dose, maintain that method of delivery for three months , then measure again , also with a blood calcium measurement at that time if that measurement is available , (i.e. if doctor is willing ?). If you change variables too much , i.e capsules for a time , then spray , or different doses then you must allow 3 months to pass on one single regime , in order to accurately measure your response.
As mentioned before try to ensure you are obtaining sufficient other vitamins and minerals. Healthy food is of prime importance. There is lots of K1 in greens, particularly dark greens. Your own body converts some K1 to K2 . If you suspect that you do not have sufficient K1 or K2 then supplementation would be an option. However , as far as I know , there is no scientific evidence ( peer reviewed scientific papers ) showing that K2 supplementation is extra beneficial with Vit d supplementation. There is evidence that IF you are deficient in K2 , then , an increase is beneficial. But of course that could be said of every essential vitamin or mineral etc that we need. . If you take extra K2 , will it harm you ?, probably not - as far as we know, at the moment. Products from grass fed( but not predominantly corn fed ) animals i.e butters from New Zealand or Ireland or some cheeses that have been fermented by bacteria that produce K2 may be a good source . i.e edam.
Hope this is helpful ! BTBH
PS. For other readers of this thread , Here is the thread with lots of Vit d discussion . Vit K2 towards the end.
www.mumsnet.com/Talk/general_health/2421492-Vitimin-D-can-it-have-this-effect
PPS. A technical point ; The reason I do not recommend frequent dose changes i.e. 3000 to 12000 , then 6000 over just a few weeks is that your cells produces an enzyme (24 hydroxylase), in response to higher levels of Vit d …. Your bodily enzyme systems get used to a particular level of Vit d, unwanted Vit D is degraded by this enzyme. If suddenly you have much less Vit D , i.e. you suddenly halve your dose ,12000 to 6000 IU , then your boosted levels of 24hydroxylase may degrade those molecules which you may need. See the work of Prof. Veith , Mt Sinai Hospital , Toronto, Canada. He is a world authority.
Here are a few of his interesting comments re Vit D .. :
BTBH