my son had amoxycillin for ear infections and has always had to have 3 doses within the first day. i was told to make sure there is around 4 hours between doses if possible.
when it's bad i usually wake during the night and keep the doses strictly 8 hours apart after that but im lucky my son will take medicine when he's half asleep with a medicine syringe then go back to sleep.
could that be an idea for you? i did it around 10.30pm then 6.30am then 2.30pm again.
good luck.i know it's horrible.my son gets it alot as well as ear infections.