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Has anyone sucessfully withdrawn from mirtazapine ?

14 replies

hardshipuntold · 18/07/2011 19:04

ive been on this for 4 years after having a post natal depression and massive financial troubles
im doing well life is good ,kids are all at school so have been very slowly withdrawing from this drug
started on 45mg got down to 30mg then 15mg ,in the last 6 weeks been taking 7.5mg and now ive been 2 weeks without anything ,having withdrawals and wondered how long they take to go away
tia

OP posts:
midnightisaplace · 18/07/2011 20:23

Hi! I have now been off Mirtazapine for four months and cross fingers everything is going well. I had been taking it for a year and a half following post natal depression and I thought I would never manage to get off it. My main problem was sleep. I slept perfectly on Mirtazapine but two weeks after I stopped taking it my ability to sleep would disappear completly. I don't do well without any sleep and therefore I would give up after a few days and go back on the tablets.

What worked for me (the third and hopefully the final time I tried to come off them) was to take half a tablet every two days for a month and then half a tablet every three days for a month and then to stop taking them completly.
My only remaining problem is that I can't bring myself to throw away the tablets I have left. They are a bit of a security blanket. I know I probably shouldn't be using them as sleeping tablets but I was on holiday last week and had problems sleeping so I took half a tablet. Had a great nights sleep but wasn't the nicest person to live with the next day!
Good luck! It's hard but doable (sp?).

hardshipuntold · 18/07/2011 21:17

i havnet been sleeping well either ,i can go off ok but waking at 2-3 am and cant get back to sleep
having anxiety symptoms too ,how many weeks did the sleep problem take to sort out?
mirtazapine is great for sleeping !!

OP posts:
midnightisaplace · 19/07/2011 07:48

Sorry to hear it is being so awful for you!

The time I actually managed to get off Mirtazapine I didn't have any major sleep problems. I think it was because of the way I withdrew so gradually.

I never had any sleep problems before PND but even now I have the odd night where I can't sleep at all. The only difference is it doesn't panic me in the same way and because of that I can usually sleep ok the next night.

hardshipuntold · 19/07/2011 10:21

i slept ebtter last night only woke once at 1am but got back to sleep ok got up at 6am
just feeling really anxious ,i hate it :(

OP posts:
hardshipuntold · 19/07/2011 10:30

i foundthis website so helpful - everything this person describes is whats happening to me
i will copy & paste it below

The withdrawal from mirtazipine depends on how long you have been taking it. Someone who has been on it for 12 months or over is going to have much more severe withdrawal symptoms than someone who has been taking them for a few weeks or months. It also depends on what type of person you are. If you are able to bear intense suffering for a month- then a cold turkey method will suit you (but you run the risk of developing serotonin syndrome where you need to be admitted to hospital because your body has gone into shock and you could die). I have chosen a slow tapering method using a solution form of mirtazapine. I went from 30mg to 15mg to 15/7.5mg using the tablet form then from 7.5mg to 6mg using the solution and a syringe. I dont advocate dropping your dosage more than 2mg once you get past the 10mg dosage. The lower the dose gets the more sensitive you are to the drop. And all this rubbish about the drug having a short half life so all the withdrawal symptoms are really your own illness is RUBBISH. Thats what psychiatrists want you to believe because they dont understand the drugs they prescribe. If you drop your dose slowly it takes 2-3 weeks for the withdrawal symptoms to gain their full whack. My own withdrawal is at its worse at 3-4 weeks but this of course depends on the person. It has little to do with the half life because you are topping up your levels every night when you take your meds. I found that after 4 weeks everything just got better and better. Its called a slow withdrawal for a reason, the symptoms take longer to materialize and last longer but they are not as severe. If you can cope with the cold turkey without killing yourself i take my hat off to you! Another thing: why start taking a dangerous drug like valium to combat the withdrawal from mirtazipine? Its like out of the frying pan and into the fire. You then have to do the whole shibang again cutting up pills like a junkie. However, coming from a person who has withdrawed from mirtazipine AND valium, mirtazipine is indescribably worse. So think about that when you want to go necking more pills and prolong your pain. Some helpful tips for withdrawers- Ranitidine is great for nausea. Peppermint oil (called Colpermin in the UK) helps constipation or general digestive discomfort. Piriton or drowsy anti-histamines calms itchy skin and relieves insomnia. As for the anxiety and depression and paranoia, youre on your own but im guessing from reading most of these forums on the subjects we are all fairly used to those.

Hope that helps some worried soul out there who is sick of reading the same confusing and incorrect rubbish from people who dont know what they are on about.

If you do try cold turkey (like i did a bit ago) and you go seriously mental (like i did a bit ago) dont let the GPs whack you back up to 15mg. All you have to do is go back to the dose you were one before you went cold turkey and wait a week or two and then drop it down less dramatically. Remember: YOU know what your body can take and the doctors have no idea so do it your way. These rubbish antidepressants affect everyone differently so do it intuitively.

OP posts:
kimwer · 01/09/2020 13:19

I nearly stopped reading when the poster claims "you can suffer from serotonin syndrome from withdrawing from mirtazapine". Absolute nonsense. However as there seemed to be some sensible anecdotes I continued reading, UNTIL.. The claim that "mirtazipine is indescribably worse withdrawal than valium". Well, that's just plain dangerous, not true and ignorant.
At the point of no return I continued reading. I was flabbergasted at the closing statement..
"Hope that helps some worried soul out there who is sick of reading the same confusing and incorrect rubbish from people who dont know what they are on about".
Just.. WOW!
I once had a painful operation. Although I was well informed about the procedure and the recovery period. THIS DIDN'T MAKE ME A SURGEON and I sertainly wouldn't masquerade as an absolute authority on the subject.
Please people, fact check these things.

Torvean32 · 01/09/2020 18:40

Kimwer is totally correct.
Ive had seotonin syndrome, it does not come from shock / going cold turkey.

I've been on mirtazapine before. Luckily i managed to come offthem without mamy problems.
If you do then i believe increasing the days between taking your dose is the best thing.

It might be handy to have an OTC sleep aid if you need it occasionally. It's not ideal to use mirtazapine for that.

And valium is one of the hardest drugs to come off.

danieldidcot · 10/02/2021 12:05

Does 7.5mg of mirtazapine causes sedation to you on long term use? 7.5mg only sedated me during the first few times using it, after a week it has no sedative effect anymore (not at all), however, it does have some therapeutic effect on my mild generalized anxiety and I am not thinking so negatively anymore.
I like the fact it has no sedating effect on me as I dont like relying on sedation to sleep.

Rawl86 · 22/11/2021 20:32

Hi all ,
I’ve currently been on mirtazapine 15mg for 10 days . For several reasons I wish to come off it . Has any one tapered from only being on it a short time ?

Spanishfleaflower · 20/06/2023 13:21

Kimwar is partly correct, but further statements are grossly incorrect, and in their own words, irresponsible and dangerous. Everyone’s body chemistry is unique and personal to them, so sweeping statements such as to rubbish this persons experience are both damaging and ignorant. My husband also had a truly dreadful time, despite being in daily contact with a support group (for Mertazapine withdrawal) and his experience was notably more distressing, painful and prolonged than Valium withdrawal was. For him. He endured daily ‘electric shock’ like sensations in his head for almost a month afterwards, insomnia, shaking uncontrollably, dangerous mood swings, panic, nausea and cramping, and was completely unable to work nor think at a high level. It took almost two years before his full higher brain function returned to its pre- medication state. Four years later (now) he cannot remember a single incident or experience for around 5 months after the start of the withdrawal, those experiences and memories seem permanently lost.
Seratonin syndrome is NOT caused by withdrawal of this drug in itself, as you correctly state, but Mert. can indeed cause seratonin syndrome (moderate to high risk) whilst taking it, particularly if combined with alcohol). The only time that SS might happen during withdrawal is if alternative medications are taken to help ‘ease’ the withdrawal symptoms, which cause the overload. No one's experience on here is ‘nonsense’ that is not only ignorant, but arrogant and dangerous to berate someone for sharing it. I have no doubt many, many people have been helped by this medication, but my husband was not. He only took it for 3 weeks and it took nearly a year for him to be back to his pre- medicated state, it was horrendous and cost him most of his friends and our marriage. A course of therapy helped him regain his life and start to feel ‘normal’ emotions again and for the paranoia and delusions to fade. I spoke to a support group that was run by a mature couple, and set up after their own daughter took her life after repeatedly trying, and failing, to stop taking mertazapine , because the withdrawal was so unbearable. They explained to me that she was prescribed it for sleep issues and was otherwise mentally healthy and stable before taking it. Don’t misunderstand me, I am aware that it clearly works for some people, but the experience, side effects and particularly the withdrawal can be extremely dangerous for others, so sharing experiences is vital and could be lifesaving. Thank you again to the couple who helped me put together a managed 3 month withdrawal schedule. They saved his life, and kept my family together. And thank you Hardshipuntold for sharing this experience, (which you say was very similar to your own), with this forum. I wish you all the best in your recovery.

Oldgrandma · 25/02/2025 12:33

Hi I am a grandma but am looking to anyone for info. Been on Mertazapine for 10 months 30 mgms been tapering since December first cut to 7.5 in day 15 at night then 3.75 in day 15 at night three weeks ago only take 15 at night . I have had withdrawal of anxiety and some tummy issues previously whilst cutting down but in the last week ten days anxiety has been quite bad . I am sleeping ok wake early with awful anxiety one of the reasons for trying to come off . the morning anxiety was better yesterday and today still there but not all consuming. Anyone had these symptoms that have lasted 3/4 weeks and then gradually improved I don’t want to go back on them in the day but will stay on the night one for a few more weeks before reducing again .

teg321 · 29/03/2025 23:11

I have been on Mirtazapine 45mg for 23 years and the doc is taking me off of it and using my new medication to tapper. He has given me 30mg and the new medication but oh boy do I have withdrawls. No way is this normal anxiety!

teg321 · 29/03/2025 23:12

Could anyone describe the anxiety symptoms of coming off Mirtazapine and maybe that will help to stop me worrying...

Oldgrandma · 30/03/2025 08:44

I have been tapering Mertazapine since December . I was on 30 mgms done very slow 25per cent taper every 4 to 6 weeks down to 11.25 the anxiety is awful sleep s good for about five hours then the thoughts kick in and general horrible feelings are still there but am going to try and carry on . Two doctors told me to just get off almost immediately I haven’t done this as it would seem it’s a bad idea . Not sure about your circumstances but maybe speak to your doctor . Good luck

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