The non-peroxide antibacterial activity of the typical (near median activity) manuka honey was tested against seven species of bacteria and compared with the typical (near median activity) honey with hydrogen peroxide activity. The MIC (minimum inhibitory concentration) of the honeys was found to range from 1.8% to 10.8% (v/v), indicating that the honeys had sufficient antibacterial potency to stop bacterial growth if diluted at least nine times, and up to 56 times in the presence of Staphylococcus aureus [65], the most common wound pathogen. In another study with 58 clinical isolates of Staphylococcus aureus [20] the MIC ranged from 2% to 4% (v/v). In a study of 20 isolates of Pseudomonas from infected wounds [66] the MIC of these two honeys was found to range from 5.5% to 9.0%.
Antibiotic-resistant strains have also been studied and found to be as sensitive to honey as the antibiotic-sensitive strains of the same species. The MIC for 82 epidemic strains of methicillin-resistant staphylococcus aureus (MRSA) was found to range from 3% to 8% (v/v) [67]. In this study 56 strains of vancomycin-resistant enterococci (VRE) were also examined, and the MIC values were found to range from 5% to 10% (v/v) for the manuka honey and from 8% to 20% for the second honey. In a further study the MIC values for eight strains of MRSA isolated from swabs collected from acute and chronic wounds, and 16 strains of VRE isolated from the hospital environment were all below 10% (v/v) for both honeys, as were the MIC values for 15 strains of beta-haemolytic streptococci, and seven strains of vancomycin-sensitive enterococci isolated from swabs collected from acute and chronic wounds [68].
Overall in these studies, other than those with enterococci, there was no marked difference in effectiveness between the two types of honey used. However, further research is needed to fully evaluate the effectiveness of these results.
Copy-paste from a study I found on t'internet. so it seems that Manuka is slightly better at treating Staphylococcus infections, but at that price for that little difference, I would want gold plated dancing stripping bees.
I was very surprised to find that honey is actually more effective as an antibacterial agent if diluted - apparently this is because it releases hydrogen peroxide.