First, distinguish between fasting for health and fasting for weight loss:
Intermittent fasting seems to have health benefits. However, weight loss nearly always requires a weekly calorie deficit, around 3000 cals for 1lb
(the exceptions are those for whom fasting corrects a metabolic problem or removes a trigger food / sensitivity)
If you check Mosely's Fast Diet site, he also recommends aiming for TDEE on NFDs. Our link in the OP on the main thread is to his TDEE calculator.
His site came long after the Horizon program and his advice there built on the experience of what happened when ordinary people did 5:2.
He, Mimi Spencer and the Horizon test subjects naturally ate about TDEE on NFDs, so that was their natural eating. He started with a BMI of 26, Mimi only BMI 21, so not overweight.
However, most folk coming to the 5:2 threads are overweight and got that way by eating much more than TDEE. So, unlike Michael and Mimi, on NFDs some folk eat back some / all of their calorie deficit and lose very slowly or soon plateau.
Many, many folk on these threads have lost weight on 5:2, but often by following Mosely's updated advice for ordinary overweight people, rather than what was ok for Horizon media folk or volunteer test subjects.
Some folk here naturally eat about TDEE and never need to count, so 5:2 is really simple for them (they probably don't post much) Others need to learn to eat only this amount.
Also, if you lose say a stone, your TDEE reduces, so you need to slightly reduce food again, unless you exercise more / retain muscle.
Mosely recommends exercise, as we do. In fact, he brought out the Fast Exercise book as a 5:2 companion.
5:2 works with whatever kind of food you like: Mediteranean / low carb / low fat / vegan / ....
We recommend cutting down on junk and alcohol, because scientific studies show too junk damages health over the longterm and also slows down weight loss. Again, Mosely didn't do junk and Mimi's new book for 5:2 bootcamp is based on cleaner eating.
So, the Horizon program outlined the broad theory. Our threads and Mosely's site detail the real world application.