PGT-A IVF after recurrent miscarriages

[CrazyAboutFurBabies]

Hi all,
We are currently thinking about going forward with PGT-A IVF after 4 miscarriages all under 10 weeks, 2 of them being chromosomal abnormality miscarriages. No problems actually getting pregnant.

Has anyone done this? What was your experience? What is the timeline?

We are currently at a private fertility clinic self funding. All tests came back good, TSH, AMH all good, scans all good, full blood count good, Karyotyping showed no genetic issues with either of us, Morphology was the only low one for my partner which was at 3% so considering the threshold was 4% doctor wasn’t concerned, but after the heartache and 2 surgical operations, we have both decided not to try again naturally.

Any stories would be really appreciated! X
(also posted this in Conception as not sure where to post!)

I did do a round of PGTA - also multiple miscarriages - to be honest my clinic tried to talk me out of it but I felt like I needed to at least try it to see if it gave me any answers for my recurrent losses

age 36 I didn’t get any normals…. I decided not to test again but did change protocol to very very low dose stim with tamoxifen tablets and had twins on the next round 🤣

my doctor looked smug and said basically I told you so that I didn’t need PGTA ….

a couple of things to be aware of

• it doesn’t score highly with the HFEAA - the science is still fairly in its infancy and they basically only take 5 cells to test out if 100 and only placenta cells…not baby cells - the margin of error is high and almost pot luck that the 5 they pick happens to be normal/not

if you don’t get any normals you’ve basically lost the whole round and a lot of money ….my clinic did let me transfer a low level mosaic but that’s pretty unheard of and I had to sign a disclaimer and a woman at the same clinic was refused to transfer her mosaic at the same time. Clinics will not *transfer an abnormal

• there is a big test case in USA courts at the moment where PGTA is more widely used that PGTA ends up destroying abnormal embryos which could have resulted in a healthy pregnancy - embryos are capable of self correcting

i stopped PGTA testing because if it came down to giving an embryo a chance I’d rather that than destroy it ….but I knew I could cope with another miscarriage (I’d also had 4) if I had to to be able to at least transfer it

i know I seem really negative about PGTA…I think after 5 rounds of IVF I was just really realistic and I did a LOT of research at the time. That being said the majority of women I know who transferred a PGTA tested euploid did have success

Thank you so much for replying.

I know everyone’s personal journeys are so different and no 2 women are the same, it’s just nice to get different peoples perspectives and experience

I’m sorry for all of your losses too, did you manage to find out or get any answers to your losses? Are you still on your fertility journey?

X

I suppose in the end PGTA did give me answers - as I didn’t get any euploids when I tested - and at my age the odds were that I should have got at least one euploid - most were abnormal and just one low level mosaic. So the answer was poor quality embryos I suppose

I did have success in the end and I’m very blessed - I stopped PGTA testing but changed IVF protocol to very very low dose and had twins x