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Donor conception

For anyone with experience of sperm or egg donation to share support and advice. Please remember this board isn’t for debate about donor conception.

Original poster

Donor egg results with male factor DNA Frag please

6 replies

hopefullsosbry · 25/03/2025 03:49

Hi

After 6 miscarriages and all the test we can get having been done, we are considering donor eggs with my partners sperm, but he has 35% DNA fragmentation.does anyone have any experience with success using donnor eggs with dna fragmentation? I am now 42 (met him at 36, had 1st miscarriage through natural conception then) and wondering if my ‘old eggs’ (so the clinic think) just arnt good enough to ‘fix’ the DNA (as I know eggs can fix the dna) or should I consider a sperm donor ? Would healthier sperm be more compatible with my eggs ?
we done PGT testing with our last round (3rd ICSI round) and all came back abnormal chromosome, so an educated guess would say all failed /misscariges were from abnormal chromosomes ??

if anyone has any advice or is in a similar situation and wanted to share I would be greatful, this is mind boggling to me what to do ? Thank you.

OP posts:
Sara237 · 11/04/2025 21:53

@hopefullsosbry That's a lot to get your head around. At 42, it's likely that your eggs are poor quality and are the issue more than his sperm. When I was 42, I was advised to use egg donor and my partner's sperm who also had high fragmentation. I was told that fragmentation and male factor was likely to be less significant than older eggs as the egg has most impact. But I was also told that they'd seen worse levels than mine and live births from those numbers which made it harder. You could try with sperm donor and see as it's a simpler process in one way. If you continue to have issues, it might be worth considering egg donation with his sperm. He could improve his sperm whereas eggs are affected so much by age. Wishing you well whatever you decide.

Original poster
hopefullsosbry · 12/04/2025 10:03

Sara237 · 11/04/2025 21:53

@hopefullsosbry That's a lot to get your head around. At 42, it's likely that your eggs are poor quality and are the issue more than his sperm. When I was 42, I was advised to use egg donor and my partner's sperm who also had high fragmentation. I was told that fragmentation and male factor was likely to be less significant than older eggs as the egg has most impact. But I was also told that they'd seen worse levels than mine and live births from those numbers which made it harder. You could try with sperm donor and see as it's a simpler process in one way. If you continue to have issues, it might be worth considering egg donation with his sperm. He could improve his sperm whereas eggs are affected so much by age. Wishing you well whatever you decide.

Hi, thank you so much for the reply, can I ask did you use egg donor and were the results ok with the DNA frag? Wondering if there are any statistic of dna frag with egg quality not being an issue? Thanks

OP posts:
Sara237 · 12/04/2025 10:54

Hi, when we first had IVF it was with my eggs and my husband's sperm which had high fragmentation. I was 38 at the time and over two cycles we managed one live birth out of 22 eggs, 3 of which got to blastocyst stage. I then tried donor eggs from 20 yr old and my husband's sperm and we got nothing. So ended up with double donation and have 5 amazing blasts ready to go. I do regret wasting so much time and money before getting to this stage. I think younger eggs might be able to 'fix' some sperm samples but statistically unlikely past about 38.

Original poster
hopefullsosbry · 12/04/2025 20:20

Hi, thanks for sharing .. so sorry you went through this and super happy you had a live birth massive congratulations! Ah ok thays a shame you got nothing with the egg donor, my husband is 44, what do you think the odds might be with donor eggs? do you mean when the male sperm is over 38 years old ? Or the defrag over 38% ? Sorry for confusion. And thanks so much again for sharing, xx

OP posts:
Pices · 13/04/2025 08:02

Sperm fragmentation has been associated with a higher risk of autism. There’s no way I’d use his sperm.

Original poster
hopefullsosbry · 13/04/2025 11:19

Pices · 13/04/2025 08:02

Sperm fragmentation has been associated with a higher risk of autism. There’s no way I’d use his sperm.

Oh really .. that’s interesting .. I’ll look into that .. thanks so much for the comment.

OP posts:
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