Anyone had a Monoclonal antibody infusion

[Schlerp]

Has anyone had a monoclonal antibody infusion after testing positive?

I’m due to have an infusion tomorrow and have no idea what to expect during or afterwards.

For background in case someone asks - I’m fully vaccinated but CEV and immunosuppressed so my doctors don’t think vaccines will be very effective. I’ve tested positive (and it’s shit btw not just a cold) and they offered me this monoclonal antibody treatment to try to prevent more serious disease and a stay in icu.

Bumping for you,have never heard of this but I hope it goes well and that you recover fully and quickly.

@BeetyAxe

Bumping for you,have never heard of this but I hope it goes well and that you recover fully and quickly.

Thank you ❤️

My cousin has. She didn't say much about it so I assume it was unremarkable. She didn't get too sick; she did better than her younger, non CEV sibling who had covid at the same time and spent 6 days in bed. Gladly both are now recovered. Good luck and hope you are over it quickly x

Relative of mine had it. Had to wait for a while afterwards (sorry not sure how long- 30/60 mins??) in case of reaction. No reaction at all.

They're CEV (lung issues) and covid for them (omicron recently) after the infusion was no more than a snuffly nose, and feeling a bit tired for a few days.

Good luck.

I don't know how it's gone but two hcp friends were discussing the treatment as one had a relative who was about to have it after testing positive.

They were very positive about it. I hope it goes well

I've not had one for covid, but I have had lots of monoclonal antibody infusions in the past for something else. I'm on the list to have an infusion if I test positive.

I've never had any problems with infusions, comfy chair, nurse brings me a cup of tea, cannula in, infusion on, then when it's finished I can go home. I sometimes have a headache or feel a bit bleugh afterwards but nothing a snooze can't fix. Good luck, I hope it helps you!

Oh I forgot to say, take a magazine or book to read to distract you. I had to wait after infusion finished to make sure I didn't have a reaction. To reassure you I 've never had a reaction and I've had infusions 4 weekly for a couple of years

How did it go?
I have one this lunchtime. Just back home now

I have this one: XEVUDY (sotrovimab)

I had the Sotrovimab infusion this morning.

It was 30mins on a drip and then sitting an hour to make sure there were no adverse reactions.

I’ve no idea how quickly it’s meant to work or if maybe I was due to begin recovery at that time anyway but within an hour of getting home I felt less pressure on my lungs and my sinuses felt lighter. Even managed to make a pot of soup before feeling a bit rotten again.

I’m so grateful for the NHS for getting me in quickly and efficiently & for being able to access this kind of treatment at all.

How are you @Abraxan?

I'm ok, thanks.

No obvious lessening if symptoms or anything - they suggested it could be a day or two. Mostly this afternoon I've just felt shattered.

I'm day 5 (from lft in the being; day 4 from pcr and most symptoms) and my lft today is as positive as ever with a thick red line still.

Hope you start to feel better soon

Hope it goes well. I have had 4 doses, CEV but my consultant says I don’t qualify for any treatments! So will have to hope I get on a trial if I catch it.

I hadn't received the letter or pcr kit, but eligible for 4th vaccine and gp mentioned it being a possibility.

I'd not heard anything and did apply for the government trial form their site. But I was randomly selected for the diary only trial, but the antiviral.

I got a pcr just incase. Then spoke to gp who chased it yesterday. Got a nurse call today and they had me go straight in

So, if you do test positive it's worth getting a pcr and then Contacting your GP and asking again.

There is a facebook group called Clinically Vulnerabke Families (CV/CEV) UK - lots of lovely people and some of them have had it.

The afternoon of infusion and the day after I felt not too bad. Symptoms eased off but by yesterday they were coming back and today it’s just the same as before. I’m hoping the virus hasn’t taken over again and that the antibodies are still working.

I went from feeling relatively normal on Wednesday to complete crap this morning & unable to get out of bed.

And they say this is “milder” and that’s why our protections are ending.

2.5 days later I think I'm starting to turn the corner. My headache is reducing. Im still tired and sleepy but don't feel quite is out of it.

Certainly my LFT yesterday was much much daunted. One I've just done is invalid annoyingly as even control line hasn't worked properly. I'll do another one shortly - when I've the energy to go back downstairs again!

In desperate for the LFTs to be consistently negative as supposed to go away in a fortnight!

Today's new LFT is completely negative.
I'm assuming that's the antivirals reducing the viral load.
The one I did the morning of the infusion, 2 days ago, was still very very positive.

I tested positive in Wednesday and had the infusion in the Thursday, my symptoms started easing off Friday night and today I feel so much better. I’m CEV due to being immunosuppressed and as a sidekick also have bad asthma. Really hoping the worst has passed as I felt awful.