Meta-Analysis that showed Ivermectin benefit contained rubbish data

[MissConductUS]

Some of which was outright fraudulent. On reanalysis, there was no evidence of benefit.

In Re-Analysis, Ivermectin Benefits Disappeared as Trial Quality Increased — When studies with a moderate or greater risk of bias were removed, survival benefit vanished

How anyone thought a worming medicine for animals could effectively treat Covid is beyond me.

People believe what they want to believe. Anti-vaxxers seized on ivermectin because they wanted to think that there was an effective prophylactic alternative to getting microchipped by Bill Gates.

I am on day 7 of Covid. I was invited to participate in the Principle trial but I backed out when I was assigned Ivermectin. I feel rough enough with Covid without the possible side effects that may be associated with ivermectin:
 Visual disturbances: such as blurred vision, difficulty reading, tunnel vision, floaters, black spots, abnormal colours or shapes. If this happens, do not drive or use any tools or machinery.
 CNS: dizziness, tremor, somnolence, vertigo, difficulty focussing, confusion, seizures, headache*
 Gastrointestinal: diarrhoea, nausea, vomiting, abdominal pain, lack of appetite
 Skin: rashes, which are normally mild and resolve after stopping the medication
 General: fatigue, general malaise, muscle pain*

Tbf @Angrymum22 it is also a very effective worming medicine for humans if you use medical grade. As for the rest, colour me amazed. Wonder what random thing theyll push next?

I’m no invermectin promoter (and yes it is v much pushed by the anti-vax lobby) but it isn’t quite as black and white as saying it is definitely no use at all.
My FIL was recently part of this study by Oxford University into whether Invermectin is any use in treating Covid:
www.ox.ac.uk/news/2021-06-23-ivermectin-be-investigated-possible-treatment-covid-19-oxford-s-principle-trial
I don’t think it’s delivered results yet?

Fact check on the claim that it won a Nobel prize - it didn't

www.reuters.com/article/factcheck-nobel-ivermectin-idUSL1N2QB2XA

Scientists who worked with invermectin (and other drugs) win the prize for breakthroughs in the treatment of parasitic diseases

@UnmentionedElephantDildo

Fact check on the claim that it won a Nobel prize - it didn't

www.reuters.com/article/factcheck-nobel-ivermectin-idUSL1N2QB2XA

Scientists who worked with invermectin (and other drugs) win the prize for breakthroughs in the treatment of parasitic diseases

Fact checked your fact check.

eu.usatoday.com/story/news/factcheck/2021/09/14/fact-check-ivermectin-did-win-nobel-prize-not-proven-covid-19/8258399002/

Satoshi Omura was awarded the Nobel prize for the predecessor of Ivermectin known as avermectin.

But thanks for proving my point though, it’s things like this that prevents open discussion and acceptance of research into alternative treatments.

I agree that saying it's a "horse wormer" and there's no possibility at all of benefit is an exaggeration. Dexamethasone is given to dogs with ear infections but was trialled for Covid and proved useful.

Researchers who know far more than me have thought it's worth putting into ongoing trials because it might perhaps have some benefit. However there's no good evidence to date that it does, as per the OP.

@Porcupineintherough

Tbf *@Angrymum22* it is also a very effective worming medicine for humans if you use medical grade. As for the rest, colour me amazed. Wonder what random thing theyll push next?

It’s also fabulous for rosacea.

Plenty of countries are using it with positive results against covid. But it doesn’t fit the narrative so isn’t getting reported.

@PassingByAndThoughtIdDropIn

I agree that saying it's a "horse wormer" and there's no possibility at all of benefit is an exaggeration. Dexamethasone is given to dogs with ear infections but was trialled for Covid and proved useful.

Researchers who know far more than me have thought it's worth putting into ongoing trials because it might perhaps have some benefit. However there's no good evidence to date that it does, as per the OP.

It was the same with hydrodoxicloriquinne which got associated with bleach, Donald Trump and right wing and thus ridiculed. Korea was using it way before that in trials in hospitalisations in early 2020.

My partner has been prescribed hydrodoxicloriquinne by her consultant for years for her Lupus and Arthritis. It’s the lazy media labelling (and thus picked up on by the ill-informed) these medications, when further open discussion and research is needed.

My partner has been taken

Satoshi Omura was awarded the Nobel prize for the predecessor of Ivermectin known as avermectin

Exactly - that's why I said 'and other drugs'

And it was breakthrough for parasitic disease.

It's utterly unrelated to any covid claims. No-one is saying these drugs are not immensely important for parasitic disease.

But bringing that valuableness into covid claims is misleading at best.

The trouble with repurposing drugs without appropriate research results [[
www.thetimes.co.uk/article/covid-victim-joe-mccarron-given-ivermectin-after-antivaxers-convinced-him-to-leave-hospital-p5wfr8bs5]]

@UnmentionedElephantDildo

Satoshi Omura was awarded the Nobel prize for the predecessor of Ivermectin known as avermectin

Exactly - that's why I said 'and other drugs'

And it was breakthrough for parasitic disease.

It's utterly unrelated to any covid claims. No-one is saying these drugs are not immensely important for parasitic disease.

But bringing that valuableness into covid claims is misleading at best.

www.ncbi.nlm.nih.gov/pmc/articles/PMC7578741/

Ivermectin is an anti-inflammatory medication. It was originally used against parasitic disease, but it doesn’t bear anything on its anti-inflammatory properties that can and have been used for other purposes.

Obviously Inflammation is a key issue in severe Covid-19. Hence as the poster said above other treatments such as Dexamethasone has been trialled too, and thats also used for dogs

pubmed.ncbi.nlm.nih.gov/32678530/

So no it’s not ‘misleading at best’. It’s entirely relevant and further research is needed as well as in other existing anti-inflammatory medications.

But carry on trying to fact check.

Dexamethazone is used widely in human medicine. My sister was on it for 22 months following neurosurgery that caused temporary adrenal insufficiency. It has form as an effective anti inflammatory.
It’s used during chemo to help suppress nausea and vomiting.
It has loads of well documented uses as it is an old drug.

@Angrymum22

Dexamethazone is used widely in human medicine. My sister was on it for 22 months following neurosurgery that caused temporary adrenal insufficiency. It has form as an effective anti inflammatory. It’s used during chemo to help suppress nausea and vomiting. It has loads of well documented uses as it is an old drug.

www.ncbi.nlm.nih.gov/pmc/articles/PMC3043740/

And so has Ivermectin been around since the 70’s and used in human medication too.

www.ncbi.nlm.nih.gov/pmc/articles/PMC7644229/
Recent study suggests that ivermectin would probably only be effective on lung inflammation if it was inhaled in the same way asthma drugs are administered.
This makes sense from a clinical perspective. It still doesn’t mean that the drug will be effective,

@Angrymum22

www.ncbi.nlm.nih.gov/pmc/articles/PMC7644229/ Recent study suggests that ivermectin would probably only be effective on lung inflammation if it was inhaled in the same way asthma drugs are administered. This makes sense from a clinical perspective. It still doesn’t mean that the drug will be effective,

“It still doesn’t mean that the drug will be effective”

Well as much as medical science may rely on your expert word and say so, its probably for the best that these treatments are thoroughly researched and trialled as cheap alternative treatments could save lives in poorer countries.

@Ridingthegravytrain

Plenty of countries are using it with positive results against covid. But it doesn’t fit the narrative so isn’t getting reported.

Receipts please!

I ask for some proof of any country getting benefits from using invermectin as things ahve moved on once the initial studies were ofund to be flawed, untrustworthy...

www.pharmaceutical-technology.com/features/ivermectin-covid-19-antiparasitic-political/

Current studies exist because it's easier to actually do a study, incur all that expense, than it is to fight stupidity with common sense. They anticipate finding that it helps with some lung issues from covid and are researching that!

Apparently loads of Americans are using it with many overdosing and ending up in hospital. The irony🙄. There is a shortage of the drug in the USA. Livestock are under threat because supplies are so low.
I’m no scientific expert but as a professional who can legally prescribe medicine I would not be comfortable prescribing a worming tablet off licence to someone who is seriously ill.
I have had a good look through Google Scholar and there are lots of papers re ivermectin but few conclusions. All are recommending robust long term clinical trials.
What makes me angry are that ivermectin is being driven by anti vaxxers who are so against using a vaccine that has been clinically trialled initially in tens of thousands of people but happily support a drug that has only been trialled on a handful of people at best.

Handy tip. To research anything scientific without being sidetracked by hoax, fraud or just batshit crazy, use Google Scholar. The internet was originally invented as a closed network linking up research institutions in order that they could share and exchange data. They never anticipated the monster it would become.

@Ridingthegravytrain

Plenty of countries are using it with positive results against covid. But it doesn’t fit the narrative so isn’t getting reported.

Then why did dexamethasone get such wide positive reporting and broad subsequent use? Hint: it's because there is good clinical evidence of its efficacy.