Mixing of vaccines - good news?

[WineGetsMeThroughIt]

Sharing this here as I've seen people asking about the mixing of vaccines - either due to not wanting a second dose of AZ, vaccine mix ups, etc. There are various reasons, but this article has some info on it and how it could be good news for immune responses.

COVID-19: 'Mix and match' jabs study finds combination of Oxford and Pfizer vaccines creates robust immune response

news.sky.com/story/covid-19-mix-and-match-jabs-study-finds-combination-of-oxford-and-pfizer-vaccines-creates-robust-immune-response-12344108

It was always the prediction that mixing vaccines would result it higher immunity, good to see the research confirming it.

This is great news. However the trial is based on a four week interval between vaccines, it's not clear how that will translate with a greater gap.

I’m not sure how those who have taken 2 doses of AZ will feel now though, particularly if they’re saying just one dose of Pfizer after AZ gives you NINE times more antibodies. To me it seems like a change in narrative from ‘AZ is great just get it’ to maybe it’s not as effective as first thought.

How many are double AZ now? With far fewer antibodies it would appear. How does that affect the long term strategy if so many people now have lower antibody counts? The message of this feels slightly off to me.

I’ll tell you how most people with double AZ feel - bloody grateful to now be 92% protected against hospitalisation.

With recent news of a 1 in 16,000 chance of developing heart problems from Pfizer, I’d be quite reluctant to have it and even more reluctant to let my kids have it.

Well the next step may be having a different vaccine as a booster? I'm all for that as a double AZ.

@SecretKeeper1

I’ll tell you how most people with double AZ feel - bloody grateful to now be 92% protected against hospitalisation.

With recent news of a 1 in 16,000 chance of developing heart problems from Pfizer, I’d be quite reluctant to have it and even more reluctant to let my kids have it.

Where have heart issues been reported?

Good news hopefully also true if you had 2 az already too.
Az doesnt stop symptoms enough for herd immunity.

If 40% still get symptoms. Even if only the positive person isolates that could still be a lit of people

@janopolisdeNorthEast if you google it there is lots of info on it. From what I've read from people experiencing it and in the press it's more prevalent in young males.

I'm not sure the numbers / stats quoted the poster shared are accurate or not but a quick google will give you lots of info on Myocarditis and the Pfizer / Moderna link

www.independent.co.uk/news/health/pfizer-moderna-heart-inflammation-myocarditis-b1873166.html

Those stats came from a pediatric professor in Israel, who are ahead of other countries in vaccine rollout and therefore data. He quoted US stats 1:16,000 chance for kids 12-17, or Israeli stats 1:6000 chance age 16-19. More prevalent in males.

Prof. Tzachi Grossman, the head of the organization, and its colleagues wrote that the risk for a child to develop a severe form of COVID if infected – which stands at 1:3000 – outweighs that of developing a myocarditis – which according to US data for ages 12-17 stands at 1:16,000 (according to Israeli data for the age group 16-19, the occurrence was 1:6,000).

@Thewiseoneincognito

I’m not sure how those who have taken 2 doses of AZ will feel now though, particularly if they’re saying just one dose of Pfizer after AZ gives you NINE times more antibodies. To me it seems like a change in narrative from ‘AZ is great just get it’ to maybe it’s not as effective as first thought.

How many are double AZ now? With far fewer antibodies it would appear. How does that affect the long term strategy if so many people now have lower antibody counts? The message of this feels slightly off to me.

If you read the article it explains that this result is over a 3 week gap and they expect a different result after 12 weeks. It's already known that AZ immunity increases more slowly and they are trialling a 12 week gap as well.