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Vaccine antibody trial

8 replies

thisisbull · 27/05/2021 08:32

Anyone else on one? I got picked for one because I did a really comprehensive antibody test through work and despite having had covid, and both Pfizer vaccines I have had no immune response. No T cell immunity and no antibodies.

I'm a bit nervous but basically they needed people who are ecv and have had minimal to no response to the vaccine to see if a booster jab or a higher dose is needed. I feel like I'm really contributing to something useful.

Anyone else on a trial?

OP posts:
Stealhsquirrelnutkin · 27/05/2021 16:53

No, but I'm very interested in following the trial and hope that a solution is found to enable a protective immune response in all the people currently not being helped by the vaccination programme.

It must be very worrying and disappointing to find out that you have neither T cell nor antibody immunity after being infected and then having both doses of vaccine.

There are several online articles reassuringly explaining that antibody levels aren't the sole criteria for measuring immune response and protection, pointing out that T cell immunity may be in place even if the antibody levels are too low to measure. Finding out that you lack a T cell response is all the more concerning, I really hope the trial is able to remedy the situation for you personally, and for all the other people currently in the same boat.

My immune system is naff, and despite having been vaccinated last Sunday I am still being cautious, hoping that when I pay for a private antibody test in 5 weeks time it will reveal a measurable immune response.

Regardless of the result I intend to continue wearing a mask, socially distancing, and glaring disapprovingly at the people on public transport who lower their masks to cough and chat. Because, regardless of whether I personally have good levels of protective antibodies I understand that some other people don't, and they might be forced to share the same spaces.

It's disheartening when people proudly announce their intentions to disregard the safety of others, in rebellion against restrictions designed to slow down, and minimise the spread of this potentially deadly or crippling virus. Especially when they claim that "Everyone at serious risk who wants a vaccine has had their jabs, so anyone who gets seriously ill or dies has only themselves to blame".

It concerns me that the government seem to be relying so much on the vaccination programme, without ensuring other basic precautions are put in place. Such as setting minimum acceptable ventilation levels for all shared spaces, with signs on the windows of restaurants (like the hygiene ratings star stickers) to show how often the volume of air inside the building is changed. The same thing should also have been done in all schools while they were locked down, with extra ventilation installed as necessary. Offices should not be allowed to insist people return from working at home if they haven't ensured adequate ventilation up to the minimum required standard. Test and trace needs to be handed over to local authorities, who do a much better job of finding contacts. A system needs to be in place that ensures that anyone required to isolate is able to get immediate deliveries of food and other necessary items, and a payment that enables them to cover their costs while they are blocked from working. Otherwise the people in the most precarious economic situations, who often work in close proximity to other people and who are more likely to travel by public transport will continue going to work if they don't have any symptoms and just can't afford to do without their next pay packet.

Unsure33 · 27/05/2021 18:13

We had some private tests from a company that showed if you had covid and or antibodies . Of all of us at work who had the jab we all showed antibodies .

enjoyingscience · 27/05/2021 18:18

I’m part of the UCL Virus watch study - I’ve had AZ and it showed no antibodies one week after the vaccine then plenty of S antibodies after 5 weeks. DH is doing it too - he had no antibodies after a week either.

We’re doing one sample per month for 6 months. I’m so shite at the blood sample bit, it’s hilarious. Blood everywhere, every time.

Kyph · 27/05/2021 22:00

I'm also doing the UCL Virus Watch trial. Got the sore finger today from this month's test.
I am CEV and take immunosuppressive drugs.
I had no antibodies 6 weeks after the first AZ vaccine but had developed antibodies at ten weeks.
@thisisbull were you very ill with covid?

boon · 27/05/2021 22:48

@kyph do u mind me asking what immunosuppressive drugs you take? My mum takes mycophenalate and Im worried shes not built up any resistance.

Kyph · 27/05/2021 22:54

@boon
Steroids, sulphasalzine and hydroxychloroquine. I read some research on vaccine response in people with autoimmune disease and it suggested that the drugs with most impact on vaccine were steroids and methotrexate. Don't know about mycophenalate.

PaulaTrilloe · 27/05/2021 23:34

I am doing the virus watch antibody study. ONS also now running Antibody test

thisisbull · 28/05/2021 01:31

@Kyph I was admitted to hospital but not icu. However I was there for 2 weeks on O2 and off work for 8 Weeks after. I was so surprised to have no response at all

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