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Original poster

AZ vaccine is the 2nd dose EXACTLY THE SAME as the 1st?

20 replies

Emma2021 · 30/04/2021 21:44

Hello

Lots of worry, wating for news etc re AZ and clots. Read many times if you had the first and no clots should not happen on the second

We have 4 cases for the 2nd with clots but no time frames given when 2nd was taken and when diagnosed.

I am amusing the second dose is exactly the same as the first or is there any kind of variation etc, even if its very, very little?

Thanks

OP posts:
Motorina · 30/04/2021 21:56

Both doses are the same.

Cookerhood · 30/04/2021 21:58

Both 0.5mL.

PurplePumpkinDream · 30/04/2021 22:16

Do we know what sort of clots? The CVST or other thrombosis? While the CSVT is apparently very rare but can happen without vaccine in younger people, the others can happen in older people for no particular reason. It would help to know more.

NLM20 · 30/04/2021 22:46

I’ve been looking out for more data on these second dose cases and nothing I’ve seen yet. I had assumed if your body didn’t make that rare autoimmune reaction to it first time, then it wouldn’t do it next time.
It’s so frustrating there’s not much information as so many people are due their second doses and in a younger age group or due their first doses and in the 40s groups which from the latest data, seems to have as much cases as the 30s.

Sanchez79 · 30/04/2021 22:50

I had my second AZ recently, mid 30s, healthy and they explained to me that the risk of clotting is lower with second dose. Not sure why.

Original poster
Emma2021 · 30/04/2021 22:57

Thanks when you say both are the same, does this include exactly the same ingredients etc, please?

OP posts:
Wigeon · 30/04/2021 23:01

Yes, there is no difference at all between the first dose supply and the second dose supply. And any leftover second doses can be used as first doses - it’s identical.

Wigeon · 30/04/2021 23:03

I imagine the difference in the clotting risk is to do with your body having already had one dose. It’s not because the second dose is a different product - it’s not.

Original poster
Emma2021 · 01/05/2021 00:45

@Wigeon

thank you, do you have a link for this please?

OP posts:
myrtleWilson · 01/05/2021 01:04

It is the same vaccine just delivered in two shots - like all of them except J&J.

ineedaholidaynow · 01/05/2021 01:06

Why do you think the second dose would be different?

MrsFezziwig · 01/05/2021 01:17

[quote Emma2021]@Wigeon

thank you, do you have a link for this please?[/quote]
As other posters have said the doses are the same. I think if you explained what your concerns are we could probably help more.

Wigeon · 01/05/2021 07:38

[quote Emma2021]@Wigeon

thank you, do you have a link for this please?[/quote]
@Emma2021 - I’m working in the national vaccine rollout team, which is how I am certain you get the exact same vaccine for the first and second dose. There just isn’t a different kind of the same brand available in the vaccine supplies!

I can’t think of anything published that actually says that because it’s so clear to everyone!

We have sent various communications to vaccination sites which say that they can use any leftover vaccine from first dose clinics for second doses, eg see page 4 of this letter. Also, the Green Book, which is the official manual of Covid vaccination, repeatedly talks about a first and second dose of the same vaccine, and if the two doses had to be different, it would be really clear about that requirement.

Cookerhood · 01/05/2021 08:26

Yes they are all part of the same supply. You could be having your 2nd dose next to someone having their 1st & it would be out of the same vial.
Are you thinking of the fact that there was a mistake in part of the clinical trial & some people accidentally got a smaller dose?

Sanchez79 · 01/05/2021 08:33

Actually thinking about it OP, when I went for my second the two guys in the booth were prepping my injection and at that point didn't know until they asked me/ looked it up on the computer that this was my second dose - and still went ahead with the same jab. I assume that very same jab would have gone into my arm had I been there for the first. They're not marked up 1 and 2 and first/ second dose people aren't sorted into different lines or anything.

ShrinkingViolet9 · 01/05/2021 09:54

Dr Mark Porter (whose practice is administering vaccinations) confirmed on Twitter a few weeks ago that the second dose of A-Z is the same as the initial dose.

MiniMaxi · 01/05/2021 10:10

Exactly the same

Original poster
Emma2021 · 01/05/2021 18:36

Thank you all.

OP posts:
bookworm1632 · 01/05/2021 18:51

@Wigeon

I imagine the difference in the clotting risk is to do with your body having already had one dose. It’s not because the second dose is a different product - it’s not.
Exactly this - if your body is one of the unfortunate ones, destined to have an autoimmune response triggered, then you'd get it following the first dose.

I wonder if the 4 clots reported following the second dose are actually unconnected to the vaccine - not enough info out there yet to know though.

PurplePumpkinDream · 01/05/2021 19:27

@bookworm1632 hopefully just as you say. A lot of us were unaware of clots first time round but are now aware and many are feeling uneasy. I have wondered whether the 4 clots reported after the second dose are unconnected and would have happened regardless of the vaccine.

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