French vaccine producer walks away from negotiations with Commission

[Baileysforchristmas]

I think the EU are going to have problems with new contracts with vaccine producers. At least they have a good positive orders with Pfizer.

www.politico.eu/article/valneva-walks-away-from-vaccine-negotiations-with-commission/

I think the point is Valneva AREN'T a vaccine supplier lol

But they are going to supply to European countries individually?

We’ve committed significant time and effort to try to meet the needs of the central EC [European Commission] procurement process," Valneva CEO Thomas Lingelbach wrote in a press release late Tuesday. "Despite our recent clinical data, we have not made meaningful progress and have not yet secured a supply agreement."

The company said it instead would shift to negotiations with individual EU countries and interested nations outside the EU.

Sorry, what's your point??

As I said, they are not a vaccine producer. At least not yet. They MAY eventually produce a viable vaccine, but they haven't so far. Why would the commission buy an unproven vaccine when they can easily source proven ones?

Well plenty of country's bought unproven vaccines that might be why the commission is a different place in queue that others that put the money up first.

@Baileysforchristmas

But they are going to supply to European countries individually?

We’ve committed significant time and effort to try to meet the needs of the central EC [European Commission] procurement process," Valneva CEO Thomas Lingelbach wrote in a press release late Tuesday. "Despite our recent clinical data, we have not made meaningful progress and have not yet secured a supply agreement."

The company said it instead would shift to negotiations with individual EU countries and interested nations outside the EU.

I posted this on the Europe thread which massively got derailed. I think big issue with moderna and pfizer MHRA vaccines is the cost and with pfizer the temperature conditions. With restrictions on age on AZ Johnson and Johnson delayed they need another vaccine.

Granted valneva not started producing yet but the original orders were based on non producing vaccines with ? Over success.
What I don't know is what the difference is between valneva compared to j &j and AZ which has worries over clots.
If its another different type of vaccine I don't understand why EU wouldn't want to be in the queue.
Maybe individual countries will do deals as they can't do a deal if EU signed a deal so maybe helpful to some member states just not yet.
But its not just Valneva EU failed to do a deal with Norovax which uk seems to be available very soon by end quarter 2 least quarter 3.
Some member states ordered more AZ and j and j because they were cheaper.
A few have said they happily buy Denmark unwanted AZ off them.

They still arguing with AZ and that arguments got no further forward according to latest politico article the reason halix wasemt ema
EMA approved was they were not producing enough vaccines.
But come feb as soon as they found out was producing 5million some bound for the UK they suddenly said it was all for the EU.
Forgetting fact that uk had invested millions in the Netherlands plant and even sent vaccine task force there to help.
Apparently option take all fro Netherlands pla t was preferable to getting more from USA.
Turn out the USA had sent AZ vaccines to Europe so the big speech about UK and USA being vaccine nationalists and not sending anything to EU is untrue.
A lot of vaccines at Italian factory came from Maryland..
I can't see India sending any vaccines to Europe so they really need more vaccines to come online soon.
Maybe curevac or sanofi be ready soon.

What I don't know is what the difference is between Valneva compared to j &j and AZ which has worries over clots

What I can think of (I'm no expert):

.AZ and J&J use the spike protein (as opposed to the full inactivated virus from Valneva)
.AZ and J&J use non-replicating modified adenoviruses as vectors (in the case of AZ it's a chimpanzee virus, not sure about J&J)

So yes, they are different vaccine types

Maybe curevac or sanofi be ready soon

I understand Curevac is mRNA

Sanofi have two candidates (one is mRNA and the other is an adjuvanted recombinant protein-based alternative)

Sanofi have gone right back to Phase 1/2 trials so they won't be ready soon

The EU are in the process of taking AZ to court

www.politico.eu/article/eu-preparing-legal-case-against-astrazeneca-over-vaccine-shortfalls/

@3asAbird

As I understand it Valneva is an inactivated whole virus vaccine so slower to produce but pretty traditional. It is a different technology to both the mRNA and viral vector vaccines as I understand it.

Yes Sunshinegirl82 that's my understanding too.

The only question mark (as far as I'm concerned) is that it uses a proprietary adjuvant

I would prefer a non-adjuvated whole virus vaccine, but of all the ones on offer currently (in the UK) AZ would still be my preferred choice

I'm not really sure I understand why the EU is suing AZ.

I thought these things took ages in Belguim courts which is why they didn't sue before now.

And they are saying they want all their doses. AZ have failed to fulfil full orders everywhere.

So the EU getting their full order would mean doses getting delivered in from elsewhere. Which takes it away from countries that actually want to use this vaccine.

And do they really think the UK will allow export of doses- which would be allowed.

And in a few weeks time, all over 60's should be done anyway so how much AZ do they actually need.

I am just not bright enough to understand it all......

Baileysforchristmas

Yes, as if that was the right attitude to have in the middle of a global pandemic!

@Wakeupin2022

I'm not really sure I understand why the EU is suing AZ.

I thought these things took ages in Belguim courts which is why they didn't sue before now.

And they are saying they want all their doses. AZ have failed to fulfil full orders everywhere.

So the EU getting their full order would mean doses getting delivered in from elsewhere. Which takes it away from countries that actually want to use this vaccine.

And do they really think the UK will allow export of doses- which would be allowed.

And in a few weeks time, all over 60's should be done anyway so how much AZ do they actually need.

I am just not bright enough to understand it all......

I don't understand it either as it seems America had already exported az to them. Despite them saying they haven't. The serum institute surely can't afford right now with situation so dire to send all spare doses to Europe. I think with uk sites its tricky as its az uk a separate company to az Sweden. We have some member states decided no not using it like Denmark. We have some Eastern block countries who dident make orders or MHRA maybe due to cost also read they felt their population be less skeptical with s standard vaccine not new type wanting az. Many member states only using on older age groups that you would hope had been vaccinated already unless eu member states have drastically different order of priority that the uk that is up to each country to decide . Big issue is the Johnson and Johnson they were depending on it and not sure what's going on with that as may suffer same clot issues that az had.

Thanks everyone update if its different type of vaccine im surprised they don't want try it.
Putting all thier eggs in 1 expensive pfizer/moderna mhra basket .
Even those 2 had issues upscaling production and revised downwards.
I don't those valneva be ready until end of year but norovax is imminent.

I'm now expert in making deals but doing a deal with companies and EU seems like a long draws out lengthy complex process as they had exploratory talks with valneva and norovax in December its now nearly may.
We know pfizer increase price of additional orders so cost is no longer an issue.
I can understand private companies worries about consequences letting EU down.
This export ban has made pfizer life harder .

www.politico.eu/article/astrazeneca-vaccine-shortfall-production-woes-documents/

The UK i don't think has had all the az it ordered.
Neither has Australia.
No idea which other countries are short.