EMA investigates possible link between AZ and capillary leak syndrome

[Bonifacethethird]

www.standard.co.uk/news/world/capillary-leak-syndrome-astrazeneca-jab-johnson-and-johnson-jab-blood-clots-b928950.htm

What the actual f?

As if the blood clotting issue wasn't enough to worry about. Before anyone says that it probably isn't causal, that's what we were saying about blood clots so recently. And it seems that this is an extremely rare and potentially long term syndrome. Now I feel like a ticking time bomb.

Who takes aspirin as a routine painkiller (nowadays)? I rarely see it even sold in Britain.

covid control strategies have always pushed at the problem of imperfect balance of harms & benefits. With a lot of coercion thrown in.

I am a few days post AZ and trying not to over-analyse every twinge.
When I think of the stuff I cheerfully put into my body when desperate to have a baby, barely reading the side effects, I do think I am being over-cautious here.

I think they have been telling people not to take aspirin before or after the vaccine, unless you are already taking it for some other reason

@Scottishgirl85

Seriously this has to stop. I work in drug regulation and this is very normal for these sorts of investigations to go on behind the scenes for any medicine. This is what health authorities are for! If there is a risk found appropriate changes are made immediately to safeguard the public. Please trust the experts to do their job, and stop the scaremongering, which is jeopardising our way out of this nightmare.

Exactly

@lljkk

Who takes aspirin as a routine painkiller (nowadays)? I rarely see it even sold in Britain.

covid control strategies have always pushed at the problem of imperfect balance of harms & benefits. With a lot of coercion thrown in.

It's taken by some older people on a low dose and some pregnant women also. It can be an alternative painkiller for those unresponsive to paracetamol.

It's widely sold in pharmacies like Boots.

I bet if I did a poll on MN (where there should be a lot of preggos or recently preggo) that almost none have aspirin in the house, but nearly all have paracetamol. Many have ibuprofen (or related) & a small % have strong stuff (like codeine).

@PicsInRed

Interesting discussion OP.

Would this now mean we should not take aspirin before/after the vaccinations?

You shouldn't have done in the first place....

I wonder how many who got the clotting disorder had taken an aspirin beforehand. And made their outcome worse.

@PicsInRed

Interesting discussion OP.

Would this now mean we should not take aspirin before/after the vaccinations?

Well yes - I don’t think it was advised that anyone should be taking anything at all prophylactically and I’ve definitely seen advice to only take painkillers is needed afterwards.

@lljkk we have aspirin in the house although I admit my go to is ibuprofen.

I have aspirin (purchased in giant bottle abroad 10 yrs ago) but paracetamol works for me & usually whatever I have needs to be taken on an empty stomach, so paracetamol is only good choice.

I just don't get these threads - we're in the middle of a global pandemic that has killed 112,000 people. We are in a situation where our backs are against the wall and we're having to evaluate two different sets of risks against each other. There's no situation where risk is zero. It's a bit mad to expect that. The scientists have done astoundingly well to have developed a vaccine over such a short timeframe and we're really lucky to have that as an option.

I recall there was an association (though dismissed, I think?) with worse covid outcomes in those taking ibuprofen, early in the pandemic. I wonder if there was some statistically insignificant effect relating to the blood thinning properties of NSAIDs in general?

@PicsInRed I don’t know for certain but I think ibuprofen wasn’t recommended for the same reason it isn’t recommended for some asthmatics. It came out of an abundance of caution and not really knowing anything about covid at the beginning.