Multiple Random Vaccinations

[user123987076]

"The chancellor will also announce £22m of the programme's existing funding will be used in a trial to see if mixing different vaccine doses works."

www.bbc.co.uk/news/uk-56230704

Is this really going to work. The news has repeatedly pointed out these vaccines are made using different methods.

Is it going to be as ridiculous a notion as telling people to take one ibuprofen and one paracetamol tablet and that somehow that would provide them randomly with either a full dose of paracetamol or a full dose of ibuprofen. After all, they are both painkillers so it should work, right? Err, no, utter bollocks, of course that wouldn't work.

Do they think partial protection, percentages random and unknown, from multiple different vaccines given at random intervals will somehow add up to full protection.

I have never heard of vaccination being used that way in my entire life.

The government are pissing about with something beyond their understanding enough by dropping it to one dose, hardly nobody has had the second one, without this. OVER 20 MILLION VACCINATED they scream to the press, slapping themselves on the back while less than one in twenty already vaccinated has had their second dose. They keep on with this first dose mania and very few will get the second shot before the first one wears off or the virus mutates enough to make both bloody useless.

I am a person who would very much like to be vaccinated for my own benefit and that of wider society, not a guinea pig nor a sodding pin cushion.

I might well be full of shit but I developed my opinion after reading many news items, on supposedly reputable web sites, about this vaccine.

Can anyone with actual knowledge give me some reassurance this is not just ridiculous folly.

Well, unless they try, they won't know if it'll work.

It would be very helpful to know if it works should there be supply issues down the line.

Oh well if you don’t think it’ll work that’s that. Better tell the scientists that have designed and are running the trial that they are wrong. I’m sure they’ll be grateful you’ve saved them from an embarrassing mistake.

Heterologous vaccination schedules are used for some diseases already to great effect.

I think this is a really positive development

Look up heterologous vaccination. This is a known strategy that can give you better immunity than two doses of the same vaccine.

Don’t let science get in the way of outrage though...

Remember, increasing the gap between vaccinations was dismissed as ridiculous folly. Now it looks as if that strategy not only gets good immunity in a larger percentage of the population, but also improves efficacy in some, or all of the vaccines.

But we wouldn't have known if we hadn't tried.

www.nihr.ac.uk/news/worlds-first-covid-19-vaccine-alternating-dose-study-launches-in-uk/26773

It is a study carried out by reputable research institutions. Whatever the outcome, it is useful knowledge for the world generally to have and thank you to the volunteers who are willing to trial this.

HCPs do tell people to taken differing painkillers to avoid additional side effects while getting more pain relief. Hopefully this will work the same way (well, not the same way but I hope it will work).

Hooray for science.

either a full dose of paracetamol or a full dose of ibuprofen. After all, they are both painkillers so it should work, right? Err, no, utter bollocks, of course that wouldn't work.

Well that just shows you know jack shit about medicine.

The first vaccine a baby gets at 8 weeks combines diphtheria, tetanus, polio, pertussis, Hib, Hep B, they also separately get Rotavirus and Men B.

MMR is another example of a combination vaccination.

We know combinations work. I don't understand the OP.

This isn’t something Boris just pulled out of his head .. scientists, you know, the really intelligent ones who have made vaccines possible, are the ones deciding to trial this. Here’s a link. You are incorrect about vaccines never being like this, currently used in the Ebola vaccine & being trialled in HIV vaccines. There’s a chance it could actually boost your response.

www.nature.com/articles/d41586-021-00315-5

No-ones forcing you onto the trial. This will only come to fruition if there is strong data that it works (from scientists) & with full approval required. So you can probably get down from off your high horse for now and let the clever folk do their highly skilled, highly detailed research.

Have you missed the data coming out of Scotland that shows both Pfizer & AZ reduce serious illness & death by 80% and transmission by 2/3rds after ONE dose.. similar data is being fed back from all over the world. The second dose is a booster, raises protection to 90% ish and should make it longer lasting.. so it’s actually really is something to shouting & celebrate. God forbid we are doing something right in this country .. we could have everyone fully vaccinated and there’d still be people whinging 🤦🏼‍♀️

@user123987076 Actually mixing paracetamol and ibroprofen does work! Might not be as crazy as you think. Most immunity is from the first jab anyway

@Sweetnhappy

The first vaccine a baby gets at 8 weeks combines diphtheria, tetanus, polio, pertussis, Hib, Hep B, they also separately get Rotavirus and Men B.

MMR is another example of a combination vaccination.

We know combinations work. I don't understand the OP.

To be fair, that’s not quite the same. That vaccine is aimed at producing immunity to several different diseases. Here it’s using two different vaccines to produce immunity to the same disease. The op obviously hasn’t heard of (or bothered to google) this technique before.

Well you haven’t heard of heterologous schedules (or bothered to google before posting) so clearly they’re not a thing not sure what you want from this thread really?
Also your pain killer comparison doesn’t work - loads of pain killers are used in combination to good effect.
It was a gamble initially extending the window but seems in retrospect to have been absolutely the right call now we know there’s a massive reduction in death / hospitalisation from a single dose, and significant reduction in spread, it is the right thing to do to reduce mortality, hospital admissions and the chance of new mutations arising.
Maybe if you share the reputable news items which you’ve read we could help with some of your misunderstandings?

@Aposterhasnoname

Oh well if you don’t think it’ll work that’s that. Better tell the scientists that have designed and are running the trial that they are wrong. I’m sure they’ll be grateful you’ve saved them from an embarrassing mistake.

I asked for more information, which some have given.

I was seeking further education from people more in the know than what your average news report contains.

I put a request for knowledge at the end of my original post and an admission that I may be woefully lacking in understanding, so quite frankly you can keep your snotty sneering to yourself.

@PurpleDaisies thank you! I hadn't understood the post properly. You mean like first dose Pfizer, second dose AstraZeneca or vice versa may end up giving us better immunity than two of the same.

@Druidlookingidiot

either a full dose of paracetamol or a full dose of ibuprofen. After all, they are both painkillers so it should work, right? Err, no, utter bollocks, of course that wouldn't work.

Well that just shows you know jack shit about medicine.

Well this shows you are rude and nasty, so thanks for that.

Thank you very much to the very helpful posters who have shared their knowledge.

I shall go off and do some reading based on your suggestions.

Again, thank you.

[quote Sweetnhappy]@PurpleDaisies thank you! I hadn't understood the post properly. You mean like first dose Pfizer, second dose AstraZeneca or vice versa may end up giving us better immunity than two of the same.[/quote]
Yes that’s exactly right. It would be great if it was shown to work in this case because of potential supply issues in future. There are trials running now.

Also, who doesn’t use double painkillers? I regularly take paracetamol & ibuprofen together. They have the same mechanism in the brain of blocking pain receptors. Ibuprofen also targets inflammation which paracetamol doesn’t. If I only had one paracetamol & one ibuprofen left, I’d 100% take both and expect a really decent reduction in my pain!

I was seeking further education from people more in the know than what your average news report contains.

Come on. Look at your first post. It’s a huge rant about how everyone has got it wrong. There was even use of CAPS LOCK for emphasis.

If you genuinely just wanted an explanation about how using different vaccines for the first and second dose could work, why not just ask for that?

Yes Purple Daisies.

You obviously know more what was in my mind than I. So sorry to not put my words down in a way that you personally approve of.

Just how I was supposed to Google something I did not know the search terms for, I am not sure.

Sod this, I don't need attacks because I couldn't quite choose the right words to make my point as I intended.

Some people on here are nothing but bullies.

@PurpleDaisies

I was seeking further education from people more in the know than what your average news report contains.

Come on. Look at your first post. It’s a huge rant about how everyone has got it wrong. There was even use of CAPS LOCK for emphasis.

If you genuinely just wanted an explanation about how using different vaccines for the first and second dose could work, why not just ask for that?

The back-pedaling is strong in the OP

I was seeking further education from people more in the know than what your average news report contains

Dr Xand explained it all on daytime telly.

News reports on this are just fine.

The AZ vaccine was tested with a 12 week lag between doses.

The Pfizer one wasn’t but as has been explained many times not tested within X conditions does not mean is ineffective in X conditions. Given the situation in the UK and effectiveness after 1 dose I agree with the strategy and it’s not “pissing about”.

I also agree with this trial. The vaccines have a different mechanism of action and to use your ibuprofen and paracetamol analogy - exactly - they are different but can work together. What’s the issue - the govt won’t personally be doing the trials. Who has said reducing doses of 2 vaccines = a full dose of something else. You’ve massively overreached there.

“Guinea pig... pin cushion... ”.

Wind down the hysteria and do some reading beyond MN for a more informed view.