Protection offered by 1st vaccine dose of Oxford

[Justpassingtime1]

This will give c %75 protection after 21 days will it?

I don’t know. I’d be interested to know this too!

I had mine on Thursday, I would love to know this too.
I know you are suppossed to behave as if nothing had happened, we cannot relax, but it would be good to know.

www.bbc.com/future/article/20210114-covid-19-how-effective-is-a-single-vaccine-dose

In a paper published in January, the authors explain that the vaccine offers protection of64.1% after at least one standard dose. This compares to 70.4% if you've had two full doses, or – oddly – 90% in people who have had one half dose followed by one full dose.

Meanwhile, based on these unpublished data they have seen, the Vaccine Committee hasestimatedthat, from three weeks until 9-12 weeks after the first injection, the vaccine prevents around 70% of cases of serious disease.

Because the phase three trial included two gaps between the first and the second dose – including one of six weeks and a longer one of 12 weeks – it's possible to say with more certainty that the first dose can continue to provide some protection for at least a few months before the booster shot.

I have already had Covid, so will the first vaccination give me more of a boost?

My understanding is that the protection from actually catching Covid will be around 50%
But the protection from being hospitalised is much, much higher - the trials show 100%

So within the cohort that has received its first jab, there will be instances of illness but they should be very mild and there should be very low numbers needing hospital treatment.

Please don’t take my interpretation as gospel though

Yes the doctor giving us the jab told us it starts working after about
a week and protection gradually increases over the next 2 weeks.
It is important to realise that it does not stop you from falling ill
it just means the effects of the disease will be reduced , so less chance of dying or ending up in hospital.
Also medicines impact differently on each individual so it is not possible to give complete guarantees.

It is important to realise that it does not stop you from falling ill
it just means the effects of the disease will be reduced , so less chance of dying or ending up in hospital
I've heard this many times about this vaccine, which is a mystery for me really because, what other vaccine works in this way? None that I know of. The rest of the vaccines stops you from falling ill and disease is not transmissible if you are vaccinated, I would like someone from a medical background to give an explanation to this as it doesn't make a lot of sense.
I've asked a couple of friends who are nurses and they don't understand this either, doesn't make sense to them.

Efficacy is really affected by the uptake in your individual body. I very much doubt anyone would guarantee it.
And no vaccine is a guarantee that you won’t get the disease. The hope is that you won’t get the disease, or if you do, you have a less severe case than if you didn’t have the vaccine. And no vaccine lasts for ever.

What other vaccine works like this? Well the flu one is only about 40%
certain for example.
We can just hope that in most cases we will get good immunity

twitter.com/WheatNOil/status/1339624815137722368

I found this thread really helpful in understanding how these vaccines work.

@piscis

*It is important to realise that it does not stop you from falling ill it just means the effects of the disease will be reduced , so less chance of dying or ending up in hospital* I've heard this many times about this vaccine, which is a mystery for me really because, what other vaccine works in this way? None that I know of. The rest of the vaccines stops you from falling ill and disease is not transmissible if you are vaccinated, I would like someone from a medical background to give an explanation to this as it doesn't make a lot of sense. I've asked a couple of friends who are nurses and they don't understand this either, doesn't make sense to them.

A dose of a vaccine triggers your immune response into creating antibodies. These antibodies rise over time - the higher they are, the more effective your body is at fighting off Covid.

Antibodies with the Oxford vaccine start to rise at (I think) roughly - 1 - 2 weeks after the first jab and they continue to rise up to around 18 weeks (this is the data they have, because everyone on the trial received their second dose within 18 weeks of the first)
The second jab then boosts these detectable antibodies even higher.

The higher the rate of antibodies, the more effective your immune response is.

So, if you were unlucky enough to catch Covid 2 weeks after your jab, there would be a higher chance of you experiencing symptoms than, say, 10 weeks afterwards.

You can get Covid after having both vaccines (90% effective=10% not)

What other vaccine works like this? Well the flu one is only about 40% certain for example

But the flu vaccine is a bit special, basically
WHO decides what strains of flu go into the vaccine each year. They decide what strain is the most likely to be the dominant that year and a vaccine is produced for that strain. Sometimes, their predictions are not so accurate, therefore the flu vaccine sometimes doesn't work so well, it is a bit of hit and miss.
I don't think the flu vaccine is comparable to other vaccines. Most vaccines stop you getting the illnesses and also from transmitting it (and I know nothing is 100%, but nothing in this life is...but they are in the whole very very effective!!)

Coronavirus also mutates (as we have seen...) But it doesn't mutate at the speed of the flu virus, so I hope Coronavirus is not going to be like the flu in regards of vaccine efficacy, otherwise we are doomed.

@Justpassingtime1

What other vaccine works like this? Well the flu one is only about 40% certain for example. We can just hope that in most cases we will get good immunity

The 40% for flu depends on the years. These low numbers are news, but it can be higher.

And whatever percentage in a year is in relation to all the strains in circulation. It is higher for the strains the vaccine was aimed at.

In a paper published in January, the authors explain that the vaccine offers protection of64.1% after at least one standard dose. This compares to 70.4% if you've had two full doses, or – oddly – 90% in people who have had one half dose followed by one full dose.

IIRC, and this is why people shouldn't make factual statements without checking the facts, the 70% was calculated from the average between the two regimes, which was an odd thing for the authors to do, as you can't average two different regimes. People either get one or the other.
And, IIRC, the protection offered by the best regime was higher than 90%.

In a paper published in January, the authors explain that the vaccine offers protection of64.1% after at least one standard dose. This compares to 70.4% if you've had two full doses, or – oddly – 90% in people who have had one half dose followed by one full dose.
Why don't they vaccinate people with one half dose followed by one whole dose then?

I wish someone was running a trial with the half first dose and the second full dose. I'd like to be part of that trial because think how useful that would be for distributing the vaccine in other countries (as well as the personal benefit of possibly having 90%).

@Calmandmeasured1

In a paper published in January, the authors explain that the vaccine offers protection of64.1% after at least one standard dose. This compares to 70.4% if you've had two full doses, or – oddly – 90% in people who have had one half dose followed by one full dose. Why don't they vaccinate people with one half dose followed by one whole dose then?

They do. 😁

I stand corrected on the 90%, and confirm the rest.

www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32623-4/fulltext

Notice the very wide confidence intervals, though.
60 something to 97 for the most effective regime. I hope a more accurate figure is calculated as the vaccine is implemented.
So, don't assume it is 90%. It could well be a lot lower.

Sorry. Ignore my they do comment. Should check first