I've copy and pasted the transcript from the feed below, for those that might be interested or missed it:
09:01
A final word: If you had three sentences for the public this morning, what would you say?
Sir Patrick first offers words of hope, saying there is "light at the end of the tunnel" and science will help to get us out of this.
"If we can drive these numbers [of cases] down, that's what's going to get us out sooner," he says.
08:57
Simone in Sheffield asks: With the vaccine rollout in progress which will achieve a proportion of the population gaining immunity and individuals gaining natural immunity from actually having the virus, at what point does the combination of those factors mean the UK reaches herd immunity?
Sir Patrick says "we may not get perfect herd immunity" through vaccines.
He repeats that around 70% of the population will need to have immunity for that to occur.
"Every degree of immunity in the population makes it more difficult for the virus to spread, makes it a bit easier for things to return to normal," he adds.
"I don't think it's an absolute."
08:54
Abid Zaman asks whether we will all need to be vaccinated again if a new resistant variant comes in
Providing some good news first, Sir Patrick says there is increasing evidence the new variant of the virus found in Kent will not be resistant to our current vaccines.
But he says that as more new variants pop up, it is likely we will need to modify our vaccines.
Fortunately, he adds, the current vaccines we have are easy to tweak.
08:50
David McCormack, from Doncaster, asks: If you could go back to March 2020, what measures would you recommend to government knowing then what you know now?
A "great question", Sir Patrick says.
"You've got to go earlier and harder" than you might think you should have to.
He describes the situation as "unprecedented" and says lessons "have been learned".
Pressed further on whether there have been problems with communicating the government strategy, he says: "Of course there have."
Intriguingly, he finishes by quoting Einstein's definition of insanity as doing the same thing repeatedly "and expecting different results".
08:49
Peter Arks asks whether the government will keep the lockdown for longer if figures do not come down and what length of time if they do?
The chief scientific adviser says the numbers of coronavirus cases are "nowhere near where they need to be yet" and it is too early to be talking about relaxing restrictions.
"It's not going to be a big bang," he says - rather a "slow release" of restrictions.
08:46
Hollie Bentley asks: With a dose of a vaccine, PPE and use of lateral flow testing; do you feel it is relatively safe for indoor care home visits? If not, would you feel it is relatively safe with all of the above and two vaccine doses?
"I'm afraid my answer is, no, it's not safe," Sir Patrick says.
"This is not the time to be relaxing any measures... however difficult, however personally challenging."
Relaxing care home rules is going to be some way off based on current case numbers, he adds.
"We risk the whole thing flaring up."
08:44
Joe Quinlivan asks: How much protection do face masks offer?
Sir Patrick says they don't have the "biggest effect", but that we "do need to do it".
He stresses the importance of social distancing and hand-washing as among the most important measures in reducing transmission, saying vaccines alone will not be the answer.
08:43
Denise O'Sullivan asks whether we will have periods every year where we have to lockdown again because an old version of the vaccine is running out and people have not received their yearly top-up
Sir Patrick says it is "quite likely" we will need regular vaccination for "at least a few years", and the vaccines will likely need to be adapted each year as with the flu jab.
But he expects we will be in a much better position by winter because the vaccine will be rolled out "across large proportions of society".
In terms of the need to lockdown again in the winter, he says it is more likely that we will have less strict measures such as wearing masks, being sensible indoors and hand washing.
08:40
Roshan Raghavan-Day asks why Black, Asian, and ethnic minority groups have not been made a priority group for the vaccine, despite the huge numbers who have died from COVID and all the previous discussions about how people from these groups are far more likely to die from this virus
It's crucial that those groups that have been mentioned are "targeted" and "come forward" for vaccination, Sir Patrick says.
He says there is a "tragedy" relating to inequality and BAME groups, but says the highest risk factor has been age.
08:37
Israel has done some clinical trials and disputes the UK's claim of 89% efficacy after the first dose of the Pfizer vaccine - they claim it to be more like 33%. What are your views on this, asks Philip Dunn
Sir Patrick says in the real world, "things are seldom as good as in clinical trials".
He says there is no protection for the first 10 days as the immune system hasn't had a chance to build up - but from day 10, the efficacy is more like the 89% figure.
The chief scientific adviser adds that we should expect to see more data in the coming weeks.
08:35
Tony Henley: With the huge number of people who have had COVID, how many people do you think need vaccinating before we can remove restrictions, even slightly?
Sir Patrick begins by praising NHS workers, but says "this is very, very bad" at the moment.
He points out that only one in eight people in the UK have had the virus.
He says we know little about how well the vaccine will stop transmission - and says we will need around 70% of the country to be vaccinated before we have something like collective immunity.