Meet the Other Phone. A phone that grows with your child.

Meet the Other Phone.
A phone that grows with your child.

Buy now

Please or to access all these features

Covid

Mumsnet doesn't verify the qualifications of users. If you have medical concerns, please consult a healthcare professional.

Why has antibody testing been forgotten?

25 replies

Furtwangler · 12/01/2021 11:22

Why do you think the government has concentrated entirely on antigen testing (ie swabs to see if you have Covid right now) and dropped any plans to do antibody testing (ie blood tests to detect Covid antibodies that show you've had Covid)?

We are about to waste millions of doses of vaccine on people who are already immune. I know natural immunity may not be lifelong, but it definitely lasts over 6 months.

Since we're racing against a frightening peak in infections to vaccinate the most vulnerable, it would have been sensible to have rolled out antibody testing so that those who have sufficiently high levels of immunity could be moved down the queue, potentially allowing millions more uninfected people to have their shots sooner.

OP posts:
Furtwangler · 14/01/2021 11:29

So one gives a flying fuck about millions of doses of a life-saving vaccine being wasted, not just in this country but throughout the world? - because antibody testing has been all but dropped from the public conversation. On Mumsnet as much as everywhere else, it seems.

Public Health England have just released a study www.reuters.com/article/us-health-coronavirus-immunity/covid-19-infection-gives-some-immunity-for-at-least-five-months-uk-study-finds-idINKBN29J004 in which, out of 6,614 participants who had previously tested positive for antibodies, 42 were 'possibly' reinfected and 2 were 'probably' reinfected. Surprise, surprise, natural immunity is really effective - that's how we've evolved to survive on this planet. But this government, despite the availability of accurate antibody testing that it described as a 'game-changer' back in May - www.politicshome.com/news/article/new-gamechanger-coronavirus-antibody-test-found-to-be-100-accurate-say-publichealthengland - has failed to even try to find out the immunity status of the population, gaslighting us all that infection with Covid changes nothing. And now 4-5 million doses of vacccine are set to be wasted on people who are already immune. Good job. Care, much?

OP posts:
Furtwangler · 14/01/2021 11:30

*No-one gives a flying fuck.

OP posts:
Ostryga · 14/01/2021 11:32

I don’t want to sound simplistic, but this is the Tories we’re discussing here. They are chronically incapable of doing anything that even resembles a coherent response.

If they add in testing the whole country for antibodies, something else will fall by the wayside.

bluebluezoo · 14/01/2021 11:39

Since we're racing against a frightening peak in infections to vaccinate the most vulnerable, it would have been sensible to have rolled out antibody testing so that those who have sufficiently high levels of immunity could be moved down the queue, potentially allowing millions more uninfected people to have their shots sooner

Because it’s quicker, cheaper and safer just to vaccinate than it is to piss about with antigen testing.

Getting people in to antigen test is potentially exposing them to the virus, increasing their chance of infection, and ultimately spreading it further. Then they have to wait for results, then more travel if they are -ve for the vaccination.

We need to limit people’s movement to stop the spread. Testing before vaccination means 1000’s of people mixing with others.

Get them in, vaccinate. Far safer, quicker, and cheaper.

A quick google shows it’s about £20 for an antigen test. £3 for the oxford vaccine and £15 for the pfizer.

Cornettoninja · 14/01/2021 11:39

It’s a mixture of resources and timescale pressure.

We are (quite rightly) throwing everything at vaccinations so to expand that to include checking for antibodies requires quite a lot of resource that could be better used.

Even if we sent out home kits (and trusted people would do them correctly) it would still require a lot of administration to collate the data and format it into usable information so people could be offered/removed from the list. Doing this introduces a heap of points that mistakes can be made and enough mistakes can add up to an ineffective use of vaccines. Plus it adds more time to the point a patient is next in line to actually receiving the vaccination.

It’s far more economical to keep it as simple as possible and use wide parameters to group people for vaccinations.

We also don’t know how long natural immunity really lasts and if it crops up that natural immunity wains or isn’t as effective as the vaccine then you need to trawl back through the data to catch those missed initially.

In a less pressurised situation (low case numbers) it might be workable but it’s an unnecessary layer of difficulty otherwise.

PurpleDaisies · 14/01/2021 11:41

Having a positive antibody test doesn’t make any difference to whether you will be vaccinated or not.

Cornettoninja · 14/01/2021 11:41

Because it’s quicker, cheaper and safer just to vaccinate than it is to piss about with antigen testing

In a nutshell Grin

GinAndTonicOnIt · 14/01/2021 11:41

Hadn't even thought of this. Nipping in to say thanks to the pp's, I've learnt something new

BigWoollyJumpers · 14/01/2021 11:45

I had a letter today asking me to take part in anti-body testing, so did someone else on another MN thread. It is still happening.

We are about to waste millions of doses of vaccine on people who are already immune. I know natural immunity may not be lifelong, but it definitely lasts over 6 months

Irrelevant. Natural immunity is 100's to 1000's of times less active than immunity acquired from vaccination. Vaccinations work in a very different way, they are specifically designed, obviously, to elicit a very strong response.

BigWoollyJumpers · 14/01/2021 11:48

coronavirus.data.gov.uk/details/testing

I am sure you have seen this OP - 120,000 daily antibody tests are on-ongoing, and have been for some time. Look at Pillar 3 testing.

LegoPirateMonkey · 14/01/2021 11:52

It’s been hard to get data on immunity and reinfection but the Guardian today is reporting a study of healthcare workers shows 83% protection in people who had covid lasting twenty weeks. That’s less than six months. It’s equivalent to having the first jab perhaps. It’s less effective than having the two doses of the Pfizer vaccine at least and perhaps less effective than having two spaced doses of the Oxford vaccine. Vaccine immunity will hopefully last a lot longer than twenty weeks - I believe that the expectation is it will last twelve months and require only annual boosters. Vaccine immunity is a lot more reliable than natural immunity and it’s the only way of ever achieving herd immunity. It would be dangerous to move people down the queue for jabs because they’d recently had covid - getting the illness is not the same as a controlled and standardised dose of vaccine.

Thingybob · 14/01/2021 11:53

@BigWoollyJumpers

I had a letter today asking me to take part in anti-body testing, so did someone else on another MN thread. It is still happening.

We are about to waste millions of doses of vaccine on people who are already immune. I know natural immunity may not be lifelong, but it definitely lasts over 6 months

Irrelevant. Natural immunity is 100's to 1000's of times less active than immunity acquired from vaccination. Vaccinations work in a very different way, they are specifically designed, obviously, to elicit a very strong response.

Can you link to anything that supports your statement that vaccine induced immunity is preferable and more times more efficient than naturally acquired immunity?
Porcupineintherough · 14/01/2021 11:56

Antibodies disappear over time. So youd have to keep testing people - say once per month. So taking up another lot of time and resources.

CuriousaboutSamphire · 14/01/2021 12:04

Maybe because that's your misunderstanding... there has been so much on the news over the last few days about immunity post covid, so someone somewhere is checking!

There are many people out there who have had covid but may be unaware. There are many for whom their post covid immnity is now waning. Do you think it is at all cost effective to test them, wait a while, put them out of sync with their test call up, cause more work for testing companies, NHS staff etc etc?

@Thingybob there's been a lot in the newsover the last 24 hours. There's bound to be an article and links somewhere about the relative immunity effects!

Haffiana · 14/01/2021 12:11

It is really peculiar when a poster comes on here quoting various studies but does not seem to have

a/ thought about it or
b/ if unable to think, used google.

Why does that happen I wonder?

BigWoollyJumpers · 14/01/2021 12:41

Here is a very quick quote in pictures and words!
www.facebook.com/watch/?v=107354977871906

Bixs · 14/01/2021 12:42

Oh the irony of an OP who gets arsey when no one has replied within a whole 9 minutes, and then when people do reply disappears!

Snowpatrolling · 14/01/2021 12:55

Anti body tests are still happening.
I know 3 people who got letters for the study yesterday.
I already done mine a couple of months ago.

Almostslimjim · 14/01/2021 12:56

Because it’s quicker, cheaper and safer just to vaccinate than it is to piss about with antigen testing.

Exactly.

Fannying about taking blood, doing the antibody test, writing to the person, recording it, inviting those without antibodies to vaccine, setting future antibody tests for those with antibodies to ensure they still have them, then going round in circles again. It would take an enormous effort to do all of that, much more than just vaccinating all those who want it.

atomt · 14/01/2021 12:59

One of my friends was sent one as part of a study and the instructions specifically said it wasn't fully accurate due to false negatives...

I imagine they also don't want to give lots of people an excuse to say "I've had covid so I'm ok, I won't stick to the rules now". The research into antibodies and immunity seems to suggest those people can still spread the virus to others even if they have no symptoms themselves.

trulydelicious · 14/01/2021 13:53

@Porcupineintherough

Antibodies disappear over time. So youd have to keep testing people - say once per month

I would assume one test to confirm actual infection would be sufficient? As, even though antibodies may wane/disappear eventually, in theory most are left with T-cell immunity?

trulydelicious · 14/01/2021 13:59

@BigWoollyJumpers

Vaccinations work in a very different way, they are specifically designed, obviously, to elicit a very strong response

The thing is, this 'very strong response' could be problematic -for instance for those with autoimmunity whose immune system is already unpredictable or prone to going into overdrive.

Hence, although vaccination is per se a more 'controlled' process it may not be the most advisable route (especially for people with certain underlying conditions who may have already acquired immunity through Covid infection).

That's my view, anyway - and obviously those who are high risk (due to age/profession/underlying conditions) who have not yet been infected may indeed benefit from the vaccine

trulydelicious · 14/01/2021 14:01

@Furtwangler

By the way, the tone of your posts is very whiny and irritating

Furtwangler · 14/01/2021 23:50

@bluebluezoo - I think that would make sense if I was talking about antigen testing, but I'm talking about antibody testing where people take a fingerpick blood sample at home, and then either analyse it at home in a kit, or send the sample to a lab for analysis.

@Cornettoninja I agree that running a big antibody testing programme now would be onerous; I was trying to make the point that we should already have been doing antibody testing at least as much as antigen tests. Whatever it costs, the value of an antigen test is lost almost as soon as it is taken, because you can test negative and then catch Covid in the next 10 minutes, or day, or week. Its usefulness wanes very quickly - who would be reassured by someone saying "I had a swab test last week"? Whereas an antibody test is useful for as long as the immunity lasts - currently 5 months and counting.

@Purpledaisies I know, and I'm saying that's wrong. It doesn't automatically follow that an antibody test won't make a difference, the government/Public Health England have decided that it won't. Back in June, one scientist who was otherwise pouring cold water on the government's antibody testing plans, on the grounds their claims to accuracy weren't solid enough, nevertheless accepted they could help determine who gets a jab:

“If they’re not being used for full epidemiological studies, I think
their main function will be in deciding who to vaccinate, assuming
the vaccine comes. That will be useful — but I’m not sure it’s a gamechanger." (Andrew Preston, University of Bath)

@BigWoollyJumpers Thank you for the clip of virologist Chris Smith, I'm amazed by it! I've read far too much about Covid this past 10 months and I've never come across that figure before.

Re Pillar 3 testing, PHE were talking about 'mass-immunity testing' in April but by August Pillar 3 testing just doesn't appear in the weekly Surveillance Reports. The only antibody testing I could find was 100,000 home fingerpricks for the REACT-2 study, part of Pillar 4, whose purpose is 'to learn more about the prevalence and spread of the virus and for other testing research purposes, such as the accuracy and ease of use of home testing'. Put briefly, they ditched mass immunity testing. (The 120,000 figure was for REACT-1, also part of Pillar 4, and they were swabs, i.e. antigen not antibody tests.)

@LegoPirateMonkey That's the study that prompted me to post in the first place. You're right that it spanned only 5 months, but either natural immunity is enough to make getting Covid much less likely, or it isn't. If a person has a test that shows they already have a sufficient level of immunity, surely it makes sense, given the huge peak in infections we're seeing now, to delay giving them a shot, and give it to someone else who has no immunity?

I agree that natural immunity will vary more than vaccine immunity, but antibody tests do quantify the level of antibodies, so if mass testing had been done, those with immunity below an effective level could be weeded out. I also agree that the vaccine is the only safe way to approach herd immunity; I'm hugely pro-vaccine.

My point is that a whole arm of the government's Covid strategy was dropped in favour of massively concentrating resources on swab testing, which can only ever be a snapshot; the value of every negative result is gone after a few days, so people have to be constantly re-tested. More antibody testing would have helped save on swab tests.

Because we dropped mass antibody testing, and Covid can be asymptomatic in many people, we really have no idea how many people have been infected, so we can only guess at how many will be vaccinated unnecessarily soon. The REACT study estimated 3.4 million in August, it must be 4-5 million by now.

It also means that schools, for example, don't know which of their staff would be the safest to be on-site looking after vulnerable and key-worker children. I don't know if the situation is the same in care homes re care workers and the most vulnerable clients.

I'd also argue that the decision to address everyone as if having had Covid makes no difference whatsoever has meant that when the government does Covid announcements and press conferences, a sizeable proportion of that 4-5 million people who either know (via the few antibody tests that have been done) or suspect that they have had Covid must be thinking, "What about me? Does this apply to me? Why should I do that?" It's not a good idea to have millions of people in a state of uncertainty re something this important. There's a clear risk some will start assuming they've had it, given the needs of many to get back to work. In these circumstances, a swab test just doesn't cut it - people should be able to find out for sure, or at least to a high degree of probability.

I believe the lack of antibody testing has helped - alongside the Cummings fiasco and other failures - to promote a mindset in which people's sense of alienation from the official conversation has made it easier for them to disregard public health messages.

@Bixs Did I get arsey? I'm sorry if it came across like that, I was trying to sound despairing. There were 2 days, not 9 minutes, between the first 2 posts, and the 3rd was just a typo correction.

@CuriousaboutSamphire I'm not sure what you mean by 'put them out of sync with their test call up'. Cost effective? What about saving-lives-effective? NHS staff aren't involved in mass home antibody testing. The amount of work testing companies do - i.e. whether lab capacity is used for antigen vis-a-vis antibody testing - is for the government/PHE to decide. I'm suggesting they've got that balance wrong; that antibody testing would have saved some of the burden of having to repeat swab tests multiple times.

@Snowpatrolling I just think, nowhere near enough.

@Almoistslimjim Fannying about taking blood, doing the antibody test, writing to the person, recording it, inviting those without antibodies to vaccine, setting future antibody tests for those with antibodies to ensure they still have them, then going round in circles again. It would take an enormous effort to do all of that, much more than just vaccinating all those who want it. It's only fannying about if it's not effective, right? Or are we going to rule out possible life-saving courses of action on the grounds that they're a bit of a faff? You tell that to your grandma. Of course there'd be a certain amount of admin involved with antibody testing, but so there is with a vaccine programme. It may well be too late to do it now, but I wasn't ever arguing for that; I was pointing to the consequences, as I saw them, of not having done it when we could.

@atomt Fair enough, but nothing's fully accurate in this game, not swabs, blood tests, whatever. Here's what my blood test result said:

"Sensitivity: The test has been shown to be 100% sensitive at detecting IgG antibodies in people who have been ill from covid-19 at 14 days or more after their first symptoms. Or put another way, there were no people who had a confirmed covid-19 illness who did not develop IgG antibodies (false negatives) 14 days after their first symptoms.

Specificity: The test has been shown to be 99.63% specific. Or put another way, there were only 0.07% of people who either gave blood before SARS-CoV-2 or had a respiratory illness that was caused by another virus who tested positive for IgG antibodies (false positives)."

@trulydelicious I'm nonplussed by the whole 'vaccines elicit a much stronger response' thing. That's new to me. I had Covid pretty badly, but didn't end up in hospital. The idea that my immune system somehow reacted a lot less to that severe illness than it would to a vaccine seems counterintuitive to me - can your immune system have a greatly increased capacity to produce antibodies that is triggered by a selected part of the antigen but can never be triggered even by a severe infection by the entire, unaltered antigen? I can only try and find out more.

By the way, the tone of your posts is very whiny and irritating Well, I'm sorry you find them annoying. Try to ignore it and just have the discussion? What I do when I find a thread whiny and irritating is, I go onto another, less whiny and irritating one, without having a cheap slap at the OP.

OP posts:
Cornettoninja · 15/01/2021 00:40

The maths just doesn’t make sense. Your proposing testing 68 millionish people to find the 4 million that have possibly have antibodies. (I’m aware that 68 million figure changes if your narrowing down groups by age etc. It’s still going to be a figure that dwarfs 4 million). Anecdote alert but I know a couple of people who have had test confirmed covid but no antibodies on testing so you’re potentially looking for even less needles in the haystack.

The cost/benefit of supplying that many tests and the staffing and resources ensuring that the data is adequately recorded and applied just doesn’t add up against just giving people the vaccine regardless of their antibody status.

If we had unlimited time and resources but limited supplies of vaccines then it would absolutely make sense but that’s not the situation we find ourselves in.

New posts on this thread. Refresh page
Swipe left for the next trending thread