WHO-commissioned research into Ivermectin - promising results so far as a preventative and treatment for Covid 19

[MoleSmokes]

Why have we not heard more about Ivermectin as a cheap and possibly effective prophylactic and treatment for Covid19??

"In Far-Flung Places, COVID-19 Is Being Treated Early And Well. Here’s Why Americans Don’t Know This."
TrialSite News 27 Dec 2020

(Not just Americans who don't know this!)

trialsitenews.com/in-far-flung-places-covid-19-is-being-treated-early-and-well-heres-why-americans-dont-know-this/

This is the WHO ACT-Accelerator Research Project - Powerpoint and Video. Images attached are of slides 1, 2 and 23 from the Powerpoint Presentation:

"Collaborative Workshop • Ivermectin Against Covid-19"
Dec 16 2020

invest.medincell.com/collaborative-workshop-ivermectin-against-covid-19/

Day 2 • Ivermectin as Treatment
Dr Andrew Hill – Presentation / Video

The same video is on YouTube here:

"Ivermectin meta-analysis by Dr. Andrew Hill"

Dr Andrew Hill
www.virology-education.com/andrew-hill-md/

WHO ACT-Accelerator:
www.who.int/initiatives/act-accelerator/faq

FREQUENTLY ASKED QUESTIONS ON IVERMECTIN
answered by Dr. Pierre Kory and Dr. Paul Marik (FLCCC Alliance) Dec 27, 2020

covid19criticalcare.com/i-mask-prophylaxis-treatment-protocol/faq-on-ivermectin/

PDF version:

covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Alliance-Frequently-Asked-Questions-on-Ivermectin.pdf

Extract:

“Shouldn’t we do a large, prospective, double-blind, placebo-controlled study to “prove” it works before adopting yet another treatment that will not work?”

There are several reasons why such a study would likely be unethical to conduct at the current time. We agree that further studies can and should be done but placebo controlled RCT’s should be avoided due to the following:

▪ Currently, a total of over 3,000 patients have been included within numerous randomized, controlled trials with the overall signal of benefit in important clinical outcomes strongly positive with tight confidence intervals. This would make the likelihood of causing significant harm to study subjects in a medical research trial using placebo to be unacceptably high given excessive morbidity and mortality associated with COVID-19.

▪ Further, the WHO ACT Accelerator Program (www.who.int/initiatives/act- accelerator/about) sub-section focused on treatments for COVID-19 and headed by UNITAID has hired research consultants to identify and perform a global systematic review and meta-analysis of all active ivermectin trials in COVID-19. The consultant anticipates having results available from several additional, large clinical trials within the next 4 weeks, and predicts the accumula- tion of sufficient patient data in these trials to reach a conclusion and recommendation for or against use of ivermectin in COVID-19 during the month of January 2021. Preliminary analyses by the consultants were recently presented at an international research conference and all the available trial results at the time strongly supported the efficacy of ivermectin in COVID-19. If, based on the projected amount of trial data in the coming month, a recommendation for use of ivermectin in COVID-19 is issued by the WHO, any planned subsequent placebo-controlled trials would have to be terminated.

Ivermectin is effective for COVID-19: meta analysis of 28 studies
Covid Analysis, November 26, 2020 (Version 8, December 28, 2020)

ivmmeta.com

Ongoing Living Update of COVID-19 Therapeutic Options: Summary of Evidence
RAPID REVIEW, 18 December 2020

iris.paho.org/bitstream/handle/10665.2/52719/PAHOIMSEIHCOVID-19200030_eng.pdf?sequence=17&isAllowed=y

Extract:

"Currently, as to ivermectin, pooled estimates suggest significant benefits. However, included studies methodological limitations and a small overall number of events results in very low certainty of the evidence. Further research is needed to confirm or discard those findings."

(There is more detail in that document).

TrialSiteNews has been banging on about Invermectin for months:

trialsitenews.com

"Trialsite News Is The Only Digital Media Dedicated 100% To Transparent And Open Coverage Of Clinical Research Trial Sites Around The Globe. Based In The Silicon Slopes In Downtown Salt Lake City, Utah, We Are Founded By A Team Of Experts In The Clinical Trials Industry And Dedicated To Transparency, Quality And Clinical Trial Innovation."

FLCC (Frontline COVID-19 Critical Care Alliance) has been trying to get the US Senate and US medical authorities to take notice for months too but they have been bizarrely smeared as "anti-vaxxers" and "anti-Mask" to discredit them!

"We would like to emphasize that the FLCCC Alliance is not opposed to vaccination and furthermore supports policies such as mask wearing, social distancing, and hand hygiene to prevent the further spread of the SARS-CoV-2 virus. Our treatment proposals are designed first of all to mitigate the effects of the pandemic until it is overcome and to allow for an earlier return to daily life."

FLCC info:
covid19criticalcare.com/about/

• - - - -

(I searched the Mumsnet Coronavirus Board before posting this and only found two mentions of Invermectin in old posts. I thought that there was a thread specifically for all sorts of trials but if there is it didn't turn up in a search for posts with "trials" in the title.)

Following

An antiparasitic drug? I'm sure if it's promising in any way, it will going into the Recovery trial, or similar.

www.recoverytrial.net/

@ ThrowawaySecondarySchool

An antiparasitic drug

Yes, I'm aware it's being used/trialled already in other countries

Thanks for that link ThrowawaySecondarySchool - nothing comes up in Search yet.

This is a bizarre development since Ivermectin is widely used in Africa for other reasons as approved by the WHO:

"South African Health Products Regulatory Authority (SAHPRA) Bans Ivermectin with Criminal Liability"
DEC 26, 2020

"The South African Health Products Regulatory Authority (SAHPRA) has banned the importation of Ivermectin into the country. Used to treat people and animals against parasites for decades now, the drug has been hailed as a revolutionary regimen since the 1980s: since then, billions of people primarily in the tropics have been treated, and consequently, a well-known safety profile emerged. However, with growing chatter about the benefits of the drug in relation to COVID-19 (based on dozens of case series, observational and randomized controlled studies), Dr. Boitumelo Semete-Makokotela, SAHPRA’s chief executive, recently declared, “Our stance is unambiguous. This drug is not approved by SAPHRA, and any attempt to import it into the country will be dealt with by SAHPRA’s regulatory compliance unit in conjunction with law enforcement agencies such as SAPS and the SIU.” Moreover, the regulatory head pointed at a whistleblower contact to the public should anybody be aware of such activity. Given the drug’s pervasive use throughout the African continent to fight parasitic infection, the move comes at an interesting time, where mounting data points to the possible benefits of the drug. Why wouldn’t the regulatory head want to at least investigate the findings? Why an outright ban with criminal liability? What’s he afraid of?"

Continued at:
trialsitenews.com/south-african-health-products-regulatory-authority-sahpra-bans-ivermectin-with-criminal-liability/

(I do wish TrialSite News would not use silly terms like "magical", "miracle cure" and "wonder drug" - very irresponsible and unhelpful! )

Bumping as I think there is very little talk on MN regarding treatments

(I do wish TrialSite News would not use silly terms like "magical", "miracle cure" and "wonder drug" - very irresponsible and unhelpful! angry )

This.
I scan read for this type of term and instantly mistrust everything said. But I suppose it generates wider interest / clicks or whatever.

I've been reading about ivermectin. Some countries are already trialling it and so far it looks like a very plausible treatment/prophylactic.

Lots of potential which is not being realised. I suspect big pharma might have something to do with that.

It does have some unpleasant side effects though too - when I had scabies several years ago I googled treatments as the lotion gave me a horrific allergic reaction (my eyes swelled up etc) and it's not used in the UK as far as I remember for that reason.

Interesting Ivermectin is the active ingredient in the cream I use for my rosacea, they are not sure why it works but think it may have an anti inflammatory action (as well as killing idemodex mites). Rosacea is a disease caused by the sufferers immune system, just like the severe symtoms of Covid.

This is an interesting run-through of a selection of Ivermectin studies world-wide by Christy Risinger, MD (Texas).

Brief, well-presented and easy to understand - all good so far

General theme of Dr Risinger's balanced comments on each study: "These conclusions look promising but here are the shortcomings of this study - more research needed."

Her previous video covering the same ground was swiftly deleted by YouTube so I hope they leave this one up.

(In case anyone is unaware, there is heavy censorship by YouTube, Twitter and Facebook of any content that might be perceived to support treatments other than those authorised by the WHO and the US CDC. Now that WHO ACT-Activator has registered a review of evidence about Ivermectin, maybe this video will escape the YouTube scythe.

This is a rather hypocritical stance by Silicon Valley Social Media, given that Fauci has now twice admitted that he lied to the US public, first about masks (bad then good) and now about the percentage of the population he estimates need to be vaccinated to achieve herd immunity - up from 60% to over 85%.)

Anyway, here is the video:

"Ivermectin and COVID-19"
28 Dec 2020
Christy Risinger, MD

Links listed in the video description:

SIGN THE PETITION:
(NIH, update your Covid-19 guidelines regarding ivermectin so less people die)
www.change.org/p/nih-update-your-covid-19-guidelines-regarding-ivermectin-so-less-people-die/

Marik Protocol:
www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf

InVitro Ivermectin study:
www.ncbi.nlm.nih.gov/pmc/articles/PMC7129059/

Argentina Study:
media.marinomed.com/8b/7a/c7/nota-journal-of-biomedical-research-safety-adn-efficacy-iota-carrageenan-and-ivermectin.pdf

France Nursing Home Study:
translate.google.com/translate?hl=en&sl=fr&u=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS015196382030627X&prev=search&pto=aue

Egypt study:
assets.researchsquare.com/files/rs-100956/v2/39b225ad-5df4-4da7-9cbd-233bf26a0eb4.pdf

Population study in Africa:
www.ncbi.nlm.nih.gov/pmc/articles/PMC7698683/#bib0019

Epidemiological Data from Peru and other countries:
covid19criticalcare.com/i-mask-prophylaxis-treatment-protocol/epidemiologic-analyses-on-covid19-and-ivermectin/

FLCCC summary statement on Ivermectin:
covid19criticalcare.com/wp-content/uploads/2020/11/FLCCC-Ivermectin-in-the-prophylaxis-and-treatment-of-COVID-19.pdf

@MoleSmokes interesting, as it has been in use for years

Hhmm, one reason against using it, especially as a prophylaxis would be the fact that its very slow to break down and would accumulate in the aquatic environment, theres damage being done to aquatic life at the moment from flea and tick treatments on pets, if millions of people took ivermectin it could be a big problem, just a thought.

@Wbeezer

its very slow to break down and would accumulate in the aquatic environment

I was not aware of that, but I wonder how it compares to other chemicals/medicine we use regularly in high quantities

Bumping and sharing this link which I dont think has been included.

swprs.org/who-preliminary-review-confirms-ivermectin-effectiveness/?amp&__twitter_impression=true

The "Ivermectin meta-analysis by Dr. Andrew Hill" is crap. It's several levels of almighty crap.

Just a few things to point out... it claims to do GRADE assessment: where is it? That means no assessment of quality of the trials.

You don't combine different study designs (RCTs & observational study designs) in a meta-analysis forest plot. Norty. Crap.

I only checked the 2 largest of the 4 RCTs used in the forest plots of the slide summary (mortality outcome). Elgazzar & Mahmud. They are both preprint/unpublished, not been thru peer review, and not actually that big (n=about 600 patients). Elgazzar's arms are

ivermectin + cocktail of other things
vs.
hydroxychloroquine + cocktail of other things

There was no control group at all, and yet we know HxyChl leads to worse outcomes for covid patients.

Meanwhile, Mahmud's arms are

Ivermectin and Doxycycline (an antibiotic)
vs.
standard care

You can't put Mahmud & Elgazzar in the same pooled meta-analysis, bogus scientifically, like making apples & pear salad to decide how sweet oranges taste.

I haven't found the other 7 RCTs supposed to be part of the meta-analysis, I can't be bothered to look harder. Probably tiny & crap. Oh, and there's no IQR ranges or confidence intervals on HIll's column charts.

More reasons why using ivermectin may be very bad.

Thanks GabriellaMontez and MedSchoolRat

It is really useful to have comments that point out flaws in the research for lay people like myself, so I do appreciate your taking the time to look at that, MedSchoolRat.

The Swiss Policy Research article mentions that three more studies will be added to Andrew Hill’s meta-analysis and that final conclusions will be published this month.

I forgot to post a link earlier to developments in Belize, which decided to make Ivermectin available under medical supervision about the same time that South Africa banned use of Ivermectin.

These countries seem to have adopted opposing policies in response to the same situation, ie. that their populations were already using Ivermectin as a possibly effective treatment and/or preventative for Covid-19 in the absence of official Government guidance. Hard to know to what extent these decisions were made on clinical vs political grounds. Both countries must surely have access to the same data?

The Belize response at least provides an opportunity for more data to be gathered.

This link is to TrialSite News. It provides more information than any other articles I could find but there is also a heap of evangelical advocacy for Ivermectin to filter out. If I could have found an equally informative but less biased source I would have been happier - just be prepared to grit your teeth and skim over all the “wonder drug” type references.

”Central American Nation of Belize Authorizes Use of Ivermectin for COVID-19”
TrialSite News, Dec 24 2020

trialsitenews.com/central-american-nation-of-belize-authorizes-use-of-ivermectin-for-covid-19/

@Molesmokes

Hard to know to what extent these decisions were made on clinical vs political grounds

Let's hope good faith prevails and treatments that are affordable are indeed authorised if proven safe & effective

The US National Institute for Health (NIH) has issued an interim update to its recommendations for Ivermectin pending a further update in February. It previously recommended against the use of Ivermectin.

The COVID-19 Treatment Guidelines Panel’s Statement on the Use of Ivermectin for the Treatment of COVID-19
Last Updated: January 14, 2021

Recommendation

The COVID-19 Treatment Guidelines Panel (the Panel) has determined that currently there are insufficient data to recommend either for or against the use of ivermectin for the treatment of COVID-19. Results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide more specific, evidence-based guidance on the role of ivermectin for the treatment of COVID-19.

Continued at:
www.covid19treatmentguidelines.nih.gov/statement-on-ivermectin/

"NIH Updates its COVID-19 Guidelines for Ivermectin While FLCCC Pays a Visit to Hugh Hewitt"
JAN 15, 2021 TrialSite News

"the NIH changed their recommendation from against the use of ivermectin for the treatment of COVID-19 except in a clinical trial to not recommending either for or against the use of the drug for the treatment of COVID-19."

Continues at:
trialsitenews.com/nih-updates-its-covid-19-guidelines-for-ivermectin-while-flccc-pays-a-visit-to-hugh-hewitt/

"Beyond The Roundup | The NIH Updates Stance On Ivermectin"
TrialSite News Video 16 Jan 2021

Video description:

"The National Institutes of Health (NIH) invited the Front Line COVID-19 Critical Care Alliance (FLCCC) to present to this national research agency’s COVID-19 Treatment Guidelines Panel. The Panel, which is the most influential of any such group worldwide, now is taking the time to review the unfolding Ivermectin situation. Of course, such a meeting wouldn’t be possible if it were not for the dedicated, committed and relentless efforts of the physician/researchers’ embrace of a story that we have been chronicling since April. The FLCCC, led by Dr. Pierre Kory and Dr. Paul Marik, along with prominent British researcher, Dr. Andrew Hill, affiliated with the University of Liverpool in the UK, presented their respective meta-analysis findings to date."

TrialSite News Related News Articles:

"NIH COVID-19 Treatment Guidelines Panel Invites Top Ivermectin Researchers to Discuss the Evidence of Efficacy to Date"
JAN 8, 2021 TrialSite News

trialsitenews.com/nih-covid-19-treatment-guidelines-panel-invites-top-ivermectin-researchers-to-discuss-the-evidence-of-efficacy-to-date/

"NIH Updates its COVID-19 Guidelines for Ivermectin While FLCCC Pays a Visit to Hugh Hewitt"
JAN 15, 2021 TrialSite News

trialsitenews.com/nih-updates-its-covid-19-guidelines-for-ivermectin-while-flccc-pays-a-visit-to-hugh-hewitt/

Reference Links:

Dr. Kory radio interview
"Dr. Pierre Kory Of the FLCCC Alliance On The Therapeutic Value of Ivermectin in Treatment of Covid"
Jan 14th by Hugh Hewitt

"When I was exposed to Covid, my doctor quickly prescribed Ivermectin, which I had not heard of. Turns out it is the subject of a great deal of discussion. Dr. Pierre Kory is a proponent of its use. The toxicologist who advises the show believes more testing is necessary. Dr. Kory joined me this morning:"

Continues at:
hughhewitt.com/dr-pierre-kory-of-the-flccc-alliance-on-the-therapeutic-value-of-ivermectin-in-treatment-of-covid/

Whiteboard Doctor

"NIH Changes Recommendation On Ivermectin To Treat COVID-19: Breaking News!"
14 Jan 2021

"Ivermectin And Mild To Moderate COVID-19: A New Randomized Placebo Controlled Trial"
Jan 16th

Preprint:
"Ivermectin as a potential treatment for mild to moderate COVID-19 – A double blind randomized placebo-controlled trial"

www.medrxiv.org/content/10.1101/2021.01.05.21249310v1

Whiteboard Doctor Ivermectin Playlist

www.youtube.com/playlist?list=PLf5bMa9_tvRhOX1m2kZL3ixWDxxar3lg2

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