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Oxford Vaccine Trial Restarts

19 replies

MissConductUS · 12/09/2020 17:54

I just heard this, apologies if it's already being discussed.

www.scmp.com/news/world/europe/article/3101330/coronavirus-oxford-restarts-trial-astrazeneca-vaccine-after-pause

I've heard separately that the study arm in the US has not restarted, but it may shortly. This is of course very good news and means that they haven't found any other study participants who had similar symptoms to the woman in the UK who halted the trail.

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GoldenOmber · 12/09/2020 17:59

Great news

Bikingbear · 12/09/2020 18:03

Brilliant. Hope the volunteer has made a good recovery.
It would be absolutely amazing to have a vaccine by the end of the year.

flowerycurtain · 12/09/2020 18:39

Fabulous cheery news

Allmyarseandpeggymartin · 12/09/2020 18:39

Thank fuck for that.

whatswithtodaytoday · 12/09/2020 18:42

This makes me so fucking happy. I know it's silly to rest all my hopes on one vaccine, but it turns out I have.

Mindymomo · 12/09/2020 18:57

We live in hope.

BlueBlancmange · 12/09/2020 19:16

@whatswithtodaytoday

This makes me so fucking happy. I know it's silly to rest all my hopes on one vaccine, but it turns out I have.
Same here. More so than any of the others in development.
feelingverylazytoday · 12/09/2020 20:16

Great news. Still feeling very confident about this vaccine.

Ellsbells12 · 12/09/2020 21:14

@whatswithtodaytoday

This makes me so fucking happy. I know it's silly to rest all my hopes on one vaccine, but it turns out I have.
Me too babe x
Ethelfleda · 12/09/2020 21:20

Good news

MissConductUS · 12/09/2020 21:49

I'm rather hoping for one of the mRNA vaccines, like Moderna's, but I'll take whatever is on offer soonest. I'm an HCP so I'm hoping to get it early in the distribution process.

I've also volunteered for the clinical trials but am in New York, where there is very little disease activity at the moment, so I'm very unlikely to be selected.

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MarshaBradyo · 13/09/2020 07:05

Good news

Subordinatethatclause · 13/09/2020 07:10

This is why it stopped. Apparently this type of TM reaction is not unusual in vaccine trials- not hugely common but well known.

Blog tweeted by Barts
https://multiple-sclerosis-research.org/2020/09/mscovid19-coronavirus-vaccine-linked-to-ms-like-complications/?utmsource=rss&utmmmedium=rss&utmcampaign=mscovid19-coronavirus-vaccine-linked-to-ms-like-complications

Sertchgi123 · 13/09/2020 07:31

Grand news!

Ellsbells12 · 13/09/2020 08:41

@MissConductUS

I'm rather hoping for one of the mRNA vaccines, like Moderna's, but I'll take whatever is on offer soonest. I'm an HCP so I'm hoping to get it early in the distribution process.

I've also volunteered for the clinical trials but am in New York, where there is very little disease activity at the moment, so I'm very unlikely to be selected.

Sorry to sound completely dumb but what are the differences ?
AverageNSad · 13/09/2020 14:09

This is good news. Does anyone know when we can expect the vaccine to start to be rolled out? I’ve googled but there’s no general consensus!

MissConductUS · 13/09/2020 15:06

@Ellsbells12

Sorry to sound completely dumb but what are the differences ?

Not dumb at all, genetic vaccines are fairly new. First, they are quicker and easier to manufacture than traditional vaccines, so they may be available in larger quantities sooner.

There is also evidence that they'll be more effective and provide broader protection:

Synthetic DNA vaccines: improved vaccine potency by electroporation and co-delivered genetic adjuvants

Here's an excerpt.

Immunological Advantages

The main advantage of DNA vaccines is their ability to stimulate both the humoral and cellular arms of the adaptive immune system. In regards to humoral immunity, the generation of antibodies by B lymphocytes against invading pathogens is one of the most effective defenses mounted by the immune system. Vaccines that utilize live-attenuated microorganisms, killed viral particles, or recombinant viral proteins elicit the production of specific antibodies that bind superficial microbial structures on the target pathogen. Unfortunately, immunological pressure or imprecise genome replication can cause certain pathogens to accumulate mutations that reduces the effectiveness of antibodies originally generated against the pathogen. Typically, antibody responses generated by traditional vaccines target only the specific antigens found in the inoculum, and are poorly able to control similar pathogens that carry either subtle or gross changes to the antigen. Due to the ability to genetically modify the antigen encoded by DNA vaccines, the vaccine can be designed to contain the most highly conserved regions of the superficial, antibody-generating structures on a pathogen, providing a means to generate broadly neutralizing antibodies against pathogens such as HIV and the influenza virus.

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alittleprivacy · 13/09/2020 15:26

@MissConductUS PfizerBiontech, mRNA vaccine is looking excellent also and may have a report at the same time if not before OxfordAstraZeneca.

@Ellsbells12 Sorry to sound completely dumb but what are the differences?

These two vaccines are very similar in how they produce an immune response. The difference is the vaccine vector, the method through which it enters the body. O/AZ uses a chimpanzee adenovirus. P/Bt uses a new method to inject the DNA of the virus directly into the bloodstream.

Here's an excellent breakdown of the frontrunner vaccines. It's from last week so won't deal with the pause in the O/AZ trial.
blogs.sciencemag.org/pipeline/archives/2020/09/03/coronavirus-vaccine-roundup-early-september

MissConductUS · 13/09/2020 15:28

Apologies, on rereading I realize I've neglected to explain the most basic difference. Traditional vaccines use killed viruses or bacteria or bits of proteins from their surfaces to activate the immune system to produce antibodies and attack them in other ways.

The Moderna vaccine uses Messinger RNA to cause your own cells to produce the spike protein found on the exterior of the covid-19 virus, which then activtes the immune system. It's quite clever, really.

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