Normal breathing uses negative pressure - your diaphragm moves down, your intercostal muscles in your ribs move upwards and outwards, which creates negative pressure. The negative pressure draws air into the lungs.
Ventilation is usually intermittent positive pressure ventilation (IPPV). Air is forced down a tube into the lungs. It's a bit like filling a balloon - the initial inflation needs a lot of pressure, then the pressure can ease off once the airways are open.
Ventilator settings need to be set very carefully. It's usual to use predicted body weight to set pressures and volumes. Giving too much air or too much pressure will damage the lungs. But if there is lots of fluid or mucous in the chest, the pressure required will be higher.
Oxygen is toxic at high levels, surprisingly, and when o2 is above 50% there can be changes in the lung structure as a result. However, if it is necessary, it's necessary.
None of it is ideal. The ideal is breathing 12-20 breaths per minute, with 95% oxygen saturation, on room air. The further someone gets away from that, the more intensive support they'll need.