Link to Report: some diabetes and heart drugs seriously worsening symptoms

[WatchThisSpace20]

This report was shared on FB by a concerned GP friend of a friend following the death of a young patient (who was taking one of the diabetes or heart drugs that this report warns about).

I wanted to share but am hoping someone with a medical background can summarise the main points to make it more accessible to posters.

eur05.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.thelancet.com%2Fjournals%2Flanres%2Farticle%2FPIIS2213-2600(20)30116-8%2Ffulltext%3Fsfns%3Dmo&data=02%7C01%7C%7C7ae4b7ca02ae438cff3208d7c9e5f6e1%7C84df9e7fe9f640afb435aaaaaaaaaaaa%7C1%7C0%7C637199861825779935&sdata=LGMariysKuDjSFOhl5NDJL%2FYMSVROFTJ9JP9y%2FeYLzg%3D&reserved=0

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I'm not a medic but what I got from it was there is a conflict with the treatment of those conditions and that of COVID19.
The treatments make the disease onset and symptoms worse maybe?
And advises medics to check treatments prior to COVID19 treatment and decide on alternative care?

May well have read it wrong.

Yes...but there was a lot of jargon around which drug regimes need changing and I thought someone could paraphrase that (and make a sort of drugs to avoid list) :)

I saw ibuprofen on there. But not medically trained in any sense. I'm sure in the light of day I could interpret it though.

Can't you ask your friend to ask you the GP?

They lost me at ACE inhibitors...

Angiotensin-converting-enzyme inhibitors are a class of medication used primarily for the treatment of high blood pressure and heart failure. They work by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart. Wikipedia
Use: High blood pressure (hypertension)
Biological target: Angiotensin-converting enzyme
People also search for: Beta blocker, Angiotensin II receptor blocker, more

Examples of ACE inhibitors include:
Accupril (quinapril)
Aceon (perindopril)
Altace (ramipril)
Capoten (captopril)
Lotensin (benazepril)
Mavik (trandolapril)
Monopril (fosinopril)
Prinivil, Zestril (lisinopril)
More items...•5 Sep 2018
www.webmd.com › guide
Types of ACE Inhibitors for Heart Disease Treatment - WebMD

@WatchThisSpace20 use Google Xx

I take an ace inhibiter for my heart condition and am worried after reading this. My condition isn't that bad, but concerned that drugs that are supposed to help might make me sick! I read something which suggested I need to be closely monitored if I get it. Have two small children so feels inevitable!
Hoping my consultant will speak to me over the phone if it becomes an issue - I'd imagine 111 will not have a clue in this instance!

Ace inhibitors are in blood pressure meds like Ramipril, my DH takes it due to a ‘mild’ heart attack last year.
I’ve been reading up on it today and there is conflicting evidence

www.sciencemediacentre.org/expert-reaction-to-questions-about-high-blood-pressure-diabetes-and-ace-inhibitor-drugs-and-risk-of-covid-19-infection/

Just make sure if anyone who takes medication (if hospitalised) gives the list of meds to the recieving health care professional and they will do their job.

OP, you say a list of drugs to avoid. These drugs aren't your over the counter medication that you can skip! These drugs are prescribed by doctors for a very good reason!

So whoever is reading this and see their medication on the list, please DON'T stop without consulting your GP!

Where is ibruprohen mentioned?

Somebody (sorry I don’t remember who, been reading so much, but thank you) posted a link to this statement a while ago on Mumsnet, which reassured me, somewhat.

www.escardio.org/Councils/Council-on-Hypertension-(CHT)/News/position-statement-of-the-esc-council-on-hypertension-on-ace-inhibitors-and-ang

Sorry when I said drugs to avoid I meant within the context of changing medications in consultation with doctor. I apologise if that wasn’t clear.

Just a note to remind everyone that we do not check the medical credentials of advice or links on the site so please don't stop any important medications without taking advice from medical professionals.

That's encouraging @thebloodykneeagain
Thanks for posting.

@Hazelnutlatteplease "Human pathogenic coronaviruses (severe acute respiratory syndrome coronavirus [SARS-CoV] and SARS-CoV-2) bind to their target cells through angiotensin-converting enzyme 2 (ACE2), which is expressed by epithelial cells of the lung, intestine, kidney, and blood vessels.4 The expression of ACE2 is substantially increased in patients with type 1 or type 2 diabetes, who are treated with ACE inhibitors and angiotensin II type-I receptor blockers (ARBs).4 Hypertension is also treated with ACE inhibitors and ARBs, which results in an upregulation of ACE2.5 ACE2 can also be increased by thiazolidinediones and ibuprofen. These data suggest that ACE2 expression is increased in diabetes and treatment with ACE inhibitors and ARBs increases ACE2 expression. Consequently, the increased expression of ACE2 would facilitate infection with COVID-19. We therefore hypothesise that diabetes and hypertension treatment with ACE2-stimulating drugs increases the risk of developing severe and fatal COVID-19."
www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30116-8/fulltext?sfns=mo

Thank you @EstherMumsnet much needed x

I get fed up of people who can't be bothered to read for themselves.