In December, the US launched strikes in Syria to "eliminate ISIS fighters, infrastructure, and weapons sites".
The MoD said RAF Typhoon FGR4s, supported by a Voyager refuelling tanker, joined French aircraft in a joint strike on the underground facility.
"Our aircraft used Paveway IV guided bombs to target a number of access tunnels down to the facility; whilst detailed assessment is now underway, initial indications are that the target was engaged successfully," the statement added.