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Conception

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pco and genetic mutations

1 reply

Jazlyn · 05/08/2025 14:32

Hi everyone, if this doesn’t belong here, I’ll delete it.
I’m writing this because women trying to conceive who haven’t undergone IVF didn’t have as detailed examinations as we girls who have already been through IVF.
I have had two unsuccessful IVF attempts, and I have PCOS.
All my embryo transfers were unsuccessful, not even a chemical pregnancy. But the thing is, now there is the “famous” ChatGPT (artificial intelligence), so I tried to ask it to explain my hematological test results in simple terms.
I have the following mutations:

  • MTHFR C677T heterozygous
  • PAI-1 4G/5G homozygous
  • GPIIIa Leu33Pro heterozygous
  • GPIa C807T heterozygous
I was told that without medical help and medication, it will never be possible for the embryo to implant successfully, even if I take something like Clostylbegyt for ovulation. Implantation is extremely difficult because of my mutations, so ovulation stimulation alone is not enough. I am interested in the opinion of more experienced women: Are these mutations really that serious? That even though I was given Fraxiparine, progesterone, and all necessary treatments, not a single embryo transfer worked? Are they so serious that I won’t be able to get pregnant successfully or have the embryo implant successfully without medical help? I understand that I will have to be under doctors’ supervision and take something to maintain the pregnancy and that I am not a simple case, but I didn’t realize it was this serious and bad — that if I had a natural ovulation, the embryo wouldn’t implant properly at all, and even if it did, it would most likely only be a chemical pregnancy. What do you think about these mutations?
OP posts:
Sajacas · 07/08/2025 08:20

Not sure how many genetic experts you are going to find to chat with you about this.
One thing to note is that genetics loads the gun and environment pulls the trigger. With out appropriate cues genes are not activated.
PCOS interestingly can be treated through diet. So although it has a genetic root, the genes that gives a person the predisposition, it might be the food environment that causes the genes to switch on and express resulting in the symptoms of PCOS:

Tsushima Y, Nachawi N, Pantalone KM, Griebeler ML, Alwahab UA. Ketogenic diet improves fertility in patients with polycystic ovary syndrome: a brief report. Front Nutr. 2024 Sep 12;11:1395977. doi: 10.3389/fnut.2024.1395977. PMID: 39328462; PMCID: PMC11424527.

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