Immune/NK cells pred thread #34

[Hopeandfaith1990]

Hi all, started a new thread as the old one was full. Not sure if this is the way to do it but I've c&p'd the list of people on the previous one as much as poss:

Old thread here: https://www.mumsnet.com/talk/conception/5228367-immunenk-cells-pred-thread-33?page=40

@Jecca88
@Gizmo1983
@Deerdancer34
@Objectiontime
@SWMum9
@TammyinCork
@Newbeginnings22023
@Fletchasketch
@Morgan236
@CarpeDiem75
@ALittleLight
@MC8
@venusStarr
@Gizmo1983
@Carportforme
@Meg310532
@Newbeginnings22023
@recurrentmis
@hopefulH
@v60
@lozzmax
@fleur89
@motherofshihtzus
@sunflower360
@kea1990
@sprinkleofbabydust
@star2022
@rumandspinach
@ems123456789
@rainbowsunshine81
@mamaw05
@thornters
@elarcoiris

Incidentally, Microgynon is not a licensed medication here in Ireland - I only got it due to sheer luck. Which is strange, as I was on it in the UK back in 2012, when I was in a different relationship, with no problems!

Hi all, just catching up.

@Gems2811 I agree with Jecca, my genetic testing probably took about 6-7 weeks to come back, I would chase with the Gynae department - recurrent miscarriage operate under them.

@Deerdancer34 Your counselling sounds so interesting and therapeutic. I wouldn't mind knowing the details if you're happy to share. My anxiety is so bad right now I need to be talking to someone tbh but its just another expense isn't it. Getting away at Christmas sounds lovely, I don't know how intralipids work but could you see if you could get in for one just before you leave?

@ChaE05 health anxiety is so hard, and I think its just made even worse by experiencing miscarriage where so much is out of your control. I was also on the Hydroxy for a year and didn't have any side effects from it - bar slightly dry skin but easily remedied. I did come off the Hydroxy at the advice of an IVF consultant I saw, but I've no idea if that was the right thing to do. I still have anxiety about it now thinking I should be taking it as I'm 7 weeks pregnant now. I think lots (tons of this thread historically if you scroll through) have successfully taken Hydroxy and for some its even been a gamechanger drug for them. I had my eye tests and all was fine after a year of being on it. I'm quite impacted by the Pred in the way of insomnia but that is an extremely common side effect of all steroids really. As Jecca says, you could give yourself a few months on it and track how you feel and go from there.

@Jecca88 lovely news on your scan, and how amazing to see him moving - must have been very special. An hour though! Wow. I can imagine it was so triggering going back to that place. You'll never forget your first loss there but I really hope with every positive experience it becomes less triggering ❤.

@TammyinCork What cycle day are you for your scan? Was the doctor basically saying its too thick already? What protocol do they want you on? Sorry for all the qs! Why did the dr put your on microgynon? To induce a bleed? Sending love sorry you've not got many answers :(

I'm going in for my scan on Friday, really bricking it but at the same time trying to be positive. PAL is just so hard. I ended up speaking to HR and my school's deputy head and have had some of my duties reduced this week but no one really gets it properly do they, even when they're trying to be sympathetic. So grateful for this group! x love to all x

ahhh sounds awful @ChaE05 - i think its worth talking to the GP to see if you can get some CBT for the health anxiety - it really helped me. I remember after my first loss - it took me about 9 months to concieve again, but then on average its about 2-3 months for each pregnancy after.

ahh @Gems2811 its defo worth calling up and seeing if they have the results back and to call as soon as they have them. Are you hoping they find nothing on the cytogenetics and you can just move on with a FET?

@Deerdancer34 sounds like a much needed break. Nightmare about the xmas eve pregnancy test - fingers crossed for you. I know that CRP want to try and get the intralipids as close to 4 weeks apart but a few days here or there is not major. It really depends when you have the pre-ovulation one.

I am sorry @TammyinCork - so shit but i know that months can change so much with scans and follicles and until stimulation you won't know. I was told i would be lucky if i got 4 eggs and i got 23.

@Hopeandfaith1990 will be thinking of you on Friday. Is the Scan in the morning?Glad you told HR, but you're right its so hard to get it unless you have been through it. Its totally all consuming. I have been there and feeling like I just could not get through it, but somehow each week i have and you will be surprised at your resilience of just putting one foot in front of the other. Its not enjoyable but please be kind to yourself.

ladies who aren’t pregnant yet and mentally struggling, have a watch of this - it may help. I’ve been following this woman for a few months now and I find her videos quite insightful but also mindset videos like this really help me. I’m sharing in case it may help you too. I’m actually thinking of signing up to her fertility circle
https://www.instagram.com/reel/DSDfkHIAcH2/?utmsource=igwebcopylink

All good guys, baby still has a heartbeat and is measuring 7w3d so exactly right for one week on. Almost doubled in size 🥰 relieved and really going to try and work on my anxiety management now I’m on my last day of school for the Christmas holidays too. Love to all xxx

ahhhh the news i was coming on here to read @Hopeandfaith1990 yay! Keep taking it day by day my love - you have got this :)

@Jecca88 I realised I counted the days wrong, pregnancy test 23rd, so have booked in for 23rd in case it is positive 🙏 Would be lovely...

@Hopeandfaith1990 Completely over the moon for you 🥰🥰🥰🥰 It's really wonderful news!

Much love to all 💞

@Hopeandfaith1990 so happy for you! I was so hoping to read this 🩷 so wonderful

Got everything crossed for the 23rd for you @Deerdancer34

Thank you for this @pagey23 and that does sound like a good idea

Thank you for your insight on the testing @Hopeandfaith1990 and @Jecca88 , I got a phone call today when I followed up and baby had Patau syndrome trisomy 13 and he was a little boy. I feel very sad but there’s some reassurance for me that it wasn’t immune related. It has shaken my confidence to try again though 😔

Thank you all! Really trying to work on the old positive mindset because my mind has been to some very dark places this week 😅

@Gems2811 I’m so sorry, it must have been incredibly difficult to receive that news and I can understand how it would impact your confidence going forward. I agree that there’s reassurance in knowing it wasn’t immune, and perhaps also that there was literally nothing more you could have done to protect him, as crushingly heartbreaking as that is, you did everything you could. Sending love xxx

Oh @gems2811 I’m so sorry to read this, I can totally relate and it really took me back when we found out our boy from Jan this year had trisomy 21. He died at just 12 weeks, but I was in a way relieved that I didn’t have to make any decision and it was taken out of our hands despite the absolute heartbreak.

It too shook me up going forward - however the hospital should offer you parental karyotype test to check if either you or your partner carry a translocation for trisomy 13- to see your chances of it happening again. Sending love! Xxx

@Gems2811 I am so sorry, its really not easy. It helps a bit to know the reason for your loss but it doesn't make it any better. Hopefully they will offer you testing and that will give you a bit more reassurance to carry on 😘

We lost my Father in Law very suddenly, so I'll be surprised if this cycle works 😔 Depends how much grief affects biology I suppose.

Lots of love everyone ❤️

@Gems2811gosh this is so awful. I’m so sorry to hear. Is there anything that you can take to lower the risk of it happening again or is it more luck of the draw kind of thing? Take care and look after yourself during this time. It’s really good to know the cause - I’ve had two miscarriages and didn’t even know it was possible to find out!

@Deerdancer34what a shock - you must all be going through so much😢 I’ve had this happen a few times and it’s hard to get your head around it. So sorry to hear this and take care. it might be worth skipping this cycle if it’s too overwhelming and they do say you need a break from the meds every 6 months so it might be a good time if you are coming up to that time? Big hugs

Oh my god @Deerdancer34 i am so sorry for your loss. Sending you so much strength in this horrible time. You poor thing, it just doesn't feel fair to have that much grief and around this time of year too. How are you?

@Gems2811 I am soo really sorry…my love and prayers are for you now….

@Deerdancer34so sorry for u too…sending you love and prayers too…

@Deerdancer34 sending you all my love, I’m so sorry :-( life can be so cruel. Thinking of you xxx

@Hopeandfaith1990@Jecca88 @pagey23 @Rainbowchaser87 Thank you ladies for your lovely words. We're just reeling from the shock and I know it will be a process to comes to terms with. It's never the right time to lose anybody but it feels too early. At least my husband is talking about it. To add insult to injury, my brother rang last night to say he'd been diagnosed with lymphoma, so waiting on prognosis of that. Anyway one day at a time is my motto with anything I find hard 😅
We had actually already triggered, so I'm continuing with the meds this cycle but I doubt implantation will work...would be a lovely miracle! Sorry for the dampener, give everyone you love an extra squeeze 💓

@Deerdancer34 gosh!! I am soo sorry that all this is happening to you! I really hope that this year won’t end with just sad news for u both but with a wonderful bfp and a baby that will thrive into your uterus! I pray your brother will fight and overcome this battle as well!! 🙏🏽
sending u love darling…you will get through this!!❤️ 🫂

@Deerdancer34 I'm terribly sorry, what a double shock for you both, sending you all the love and you're right, one day at a time. Hoping for a lovely BFP for you xxx

Hi ladies, sorry I’ve been MIA here. After our chemical last month I fell into a bit of a hole thinking this will never happen. I came off all pregnancy related apps and just gave my brain a rest.

I have happy news again that I am pregnant this month. 5 weeks today and two realllly strong dark lines at 12 and 17dpo. With my previous losses I didn’t ever get lines this dark so it feels like a positive sign. Cramping, sore boobs, all the right signs but I feel super super anxious and don’t want to tell anyone yet. Counting down until I can have the 7 week scan under the RM team.

@Jecca88 so pleased to hear about your scans, amazing. I hope you are able to relax into things a little now.

@Hopeandfaith1990 I hope you’re keeping well. I just saw your comment about seeing the heart beat at 6weeks 4 days 🥹🥹. How did you stay calm? I already feel sick thinking about that first scan, if I get there.

@ChaE05 I understand your concerns about the hydroxy. I didn’t have the normal side affects they detail but I do think the combo of that and pred messed up my cycle a little. I stopped taking it for two months but have started up again when I got a positive test.

@Deerdancer34 so sorry to hear your sad news. Thinking of you

Sending love to everyone and hello to the new comers. This is a really supportive place. Merry christmas xx

@SWMum9 congratulations darling!!! I pray this baby will thrive!!🙏🏽❤️ thanks for sharing…

Gentle congratulations @SWMum9 the really strong lines sound promising! Xx

@SWMum9 Many congratulations 🥰 The lines sound really good! I remember seeing the lines when I conceived my daughter and thinking, oh that's what they are supposed to look like 😅

Thank you all for being such a supportive group, it's a lifeline this isn't it 😘 Hope everyone doing ok 💓

That’s exactly how I felt. None of this squinting under certain lights and pretending I can see things like I’ve been doing for god knows how long 😆

Congratulations!!! What lovely news before Christmas!

Hi @SWMum9 so happy to hear from you and hear your lovely news! Congrats. When is your first scan? I absolutely did not stay calm haha. I was crying before the doctor had even put the ultrasound in hahaha. She said 'you can smile now, there is a heartbeat' and then I continued crying but happy tears then! I was the same for my second scan, crying and could barely breathe again and this one was worse because the doctor went from over the tummy to internal which obviously panicked me. I think its impossible to stay calm with our history! Be kind to yourself and let yourself feel the things you feel. I'm journally/affirming/colouring in A LOT especially as my husband has been away this week skiing.

I'm still paranoid that I should have taken the hydroxy. Did you tell RMC you stopped and started it?

Hope everyone is well. @Jecca88 how many weeks are you now and have you had any more scans?

I was doing some research last night and came across the Tommy's NK cells page - does anyone else think its strange that they're basically completely going against the NK cells now? I swear they used to support the treatment.