TTC with PCOS, Metformin, Myo-inositol and Miscarriages

[mrsalice2022]

Hello all 👋

This is my first post here and I'm hoping for some help from this lovely community please! Sorry in advance for rambling but my head is all over the place at the moment!

I was scanned and diagnosed with PCOS in November as I had gone without a period from March to September last year. The gynaecologist prescribed me with Metformin and for me to continue taking the Myo-inositol that I had already been taking.

As it happened, two weeks after our appointment I discovered that I had fallen pregnant before I had even started taking the Metformin! Sadly it wasn't to be and we lost our baby at 12 weeks earlier this month. This was my second miscarriage as I also lost a baby at 6 weeks a few years ago.

As it has only been 3 weeks since my miscarriage, I haven't had a period yet but I'm wondering whether now is a good time to start taking the Metformin along with the Myo-inositol that I'm already taking? I don't know why I'm hesitating, I just can't decide whether taking the Metformin is a good idea when I'm already taking Myo-inositol (and had managed to conceived by taking this alone) and whether now is a good time to start taking the Metformin, given that it's only 3 weeks since my miscarriage.

The reason that I would be keen to take the Metformin is that I've read that it can significantly help to reduce the chance of miscarriages, which I'm apparently at a higher risk of due to my PCOS, so could be the cause of my two losses. It may also help to bring back my periods which I'm scared won't return as they are so unpredictable, especially when I'm stressed.

Does anyone have any advice on this matter and also what dosage of Metformin and Myo-inositol should be taken when combining the two?!

Thank you so much in advance for reading this and for any advice you might be able to offer me 😊

My goodness some of your wait times have been horrendous, so sorry it's just awful isn't it.

@Shootforthestars what does having a positive result mean for you?

@RainyDaysByTheFire so managed to get a telephone consultation with the doctor. My levels were 1.2 which means a risk of clotting so said normal levels are about 2-3. So I asked about taking low dose aspirin she said to wait. My referral to recurrent miscarriage clinic has been accepted and she has forwarded on my blood results and highlighted the anticolagnant levels. She did say it's possible that this has caused the miscarriages. Advice is if I fall pregnant between now and getting seen at clinic is that I've to contact GP immediately. Its a bit bitter sweet that we might have an answer but if I'd had this test to start with things might have been different. It does make be wonder though as with first miscarriage I had a blood clot in my uterus.
We're really fortunate that we have a soon to be 11 year old, it did take us over a year to conceive him and I did end up on medication but can't remember what the medication was.
Need to get the pcos sorted as well

@Shootforthestars thank you for the explanation. It's awful you suffered those MCs and hopefully being seen for this will make your journey much smoother from here on.

Hey, sorry I know this thread is a few weeks old but I was just searching for a similar topic.

I was diagnosed with PCOS back in 2020 but actually conceived the month afterwards, so I've never discussed it with a GP or anything since then.

We're TTC our second now, been trying 4 months now. No luck yet and I have long cycles, late ovulation (between day 23-28) and a short LP of 8-9 days. In the grand scheme of things, I suppose they are fairly regular ish but just on the long side.

I started taking Free Souls PCOS Myo-inositol tablets this month and it could be a fluke but I actually ovulated on day 19 (!!)) this month. No side effects and I'm really hoping it might make a bit of a difference.

I had an ectopic last year too, add that into the mix im not sure whether the scarring from that might make it more difficult/longer to conceive. But we'll see.

@lemonyfox I’m so sorry to hear about your eptopic and wish you all the best for conceiving again ❤️ Brilliant news that you have ovulated sooner after taking the tablets! At our recent fertility appointment, the nurse recommended Inofolic Alpha by Fertility Family so I have recently changed to that 🤞🏻
Do you mind me asking, did they monitor you at all in your first pregnancy, having been diagnosed with PCOS? Having had two miscarriages, I’m worried that this is what is causing them for me.

Hi @lemonyfox sorry to hear about your ectopic last year 💕
@mrsalice2022 when I was pregnant with my son they didn't do any extra monitoring with regards to the PCOS. I did end up with growth scans due to my height as I'm only 5ft 1 and they were worried that he was going to be big
I've got another wee update about my bloods..
I got my 2nd anticoagulant (lupus) test done last week got the results on Thursday and this one is negative 🤦‍♀️ so the miscarriages might not be related to blood clotting so need to wait for appointment for miscarriage clinic coming through to see what they think.
I'm still getting accupuncture and feel it's making a difference to my cycles and moods, although I still think I'm ovulating slightly later

@Shootforthestars gosh I hope you get your answers from the miscarriage clinic soon. At least things are slowly being ruled out for you.
Thank you for your advice we pregnancy and PCOS, it is reassuring to hear that it went ok for you.
I too am going for acupuncture and I think it has been making an incredible difference to my general well-being, I couldn’t recommend it enough! I’m glad it’s helping you too.

@lemonyfox I tend to steer away from any supplements that contain maca. I've had a terrible experience with using it. I had taken it in the past but over
the course of a few months it exaggerated my pcos symptoms and screwed up my hormones and I lost my periods. I've learned not to mess with herbs as they are extremely potent. I took it as a quick google search seems to lead you to believe it's great for pcos and balancing hormones but actually there's several studies shown women with pcos shouldn't take maca so now I stick to good old plain myo inositol without any added ingredients that are going to affect my cycles.

Fair enough, there's so many different types out there so it's hard to know what to take and what not to take.

I think I need to retract my earlier comment about the myo-inositol anyway, my earlier ovulation last month probably doesn't count. I've had another ectopic pregnancy and lost my fallopian tube in this past week. I was still having periods and ovulating despite it, so I doubt the myo-inositol did anything!

Why is TTC so shit.

Sorry I missed your question, no they didn't seem bothered at all about PCOS in my first pregnancy, they were more focused on gestational diabetes testing though.