Only you know if you have the energy for a baby at this age. Don’t let anyone let you know you don’t. You already have two children so you’ve been through this before. You’re children are not so dependent on you so you can give attention to the baby.
I wouldn’t worry about genetical defects or other issues, yes, there are increased chances, so I would keep my expectations low on conceiving, but nowadays, compared to 10-11 years ago, there is a very accurate non invasive blood test for genetical abnormalities - NIPT (harmony or panorama, under other names). If you’re in uk you’ll get it for free after the combined test (they give it for W who get high risk at the combined test, they told me I would have gotten high risk just bc of my age, 42). So you can know early on and make a decision.
If you decide to go ahead, have a physical check up including all bloods, iron levels, vit d, folate level ( very important to know if you need to get some supplements first to get your levels to normal - as it can cause birth defects if you’re deficient)
Realistically, though you have a chance, it’s a small one so you could try and see what happens so you don’t regret not trying later. But equally you also have to be prepared to have a baby and think it through in advance. Good luck whatever you decide.