Repeated chemical pregnancies?

[Sparrowsong]

Is anyone else just getting one chemical pregnancy after another? I have just had my 6th of 2021 (and a mc in Dec 20). I feel like I am doomed to never carry to term!

@Sparrowsong ohh no, that's horrible! Did they do a screening yet?

I'm sorry @Sparrowsong they're not very nice! I've had a few myself. Still waiting to have a sticky one. I'll be starting my fertility testing next cycle if this one isn't successful. Sadly they're extremely common, not everyone realised they've had one though

I read a thread last night where it was as simple as the person not reacting well to folic acid and needing to take something or other folate instead. Simple blood test showed it. Good luck, and so sorry for your losses, that must have been crushing.

Thanks all! I appreciate your comments. think I just felt hopeless earlier and so alone with the recurrence of it. Literally every month. My heart breaks a little more each time.

Test Results actually in today.
I have the mthfr mutation, already acted and cut out toxic (to me) folic acid and started on methylfolate. Being prescribed levothyroxine (slightly hypothyroid) and prednisolone due to raised nk cells. Sharing in case it helps anyone else with their investigations. I can only cross my fingers.

The psychological impact I probably need to find help for, I don’t know that I will never trust my body to stay pregnant. I feel broken. If I do ever get successful I will be a nervous wreck for 9 months.

@Sparrowsong so sorry hear that, I have had 4 all back to back and feel the same way.
I have an appointment with the recurrent miscarriage clinic in 2 weeks so I am hoping for some answers.
I am so pleased you have some answers and really hope the changes work for you xx

@Sparrowsong I'm sorry to hear about the repeated losses :( I'm glad your bloods have given you some answers and hopefully the next one is sticky for you 💕
I'm the same I have had one every cycle since December :( had a general screen with the gp which was normal so I'm now waiting for my referral app. I'm luck to have a little one this would be our second. We had one the cycle before we conceived our first so was hoping the same would happen but it's been one after the other. Wishing you lots of luck 💕

I've had 4 CPs within 6 months. It turned out to be chronic endometritis (not to be confused with endometriosis!!) which is a chronic inflammation of the lining of the womb with no symptoms. Two weeks of doxycycline thanks to Tommy's CERM trial and I'm now 14 weeks pregnant.

How is everyone on the thread getting on?

After our 4th chemical in March we've had a break for a few months but I am currently 10dpo waiting to see if I get a BFP this cycle (I am not testing I am waiting to see if af arrives)

@Sparrowsong sorry to open up the thread again. I just wondered if you had any updates since your last post? We're going through our 2nd CP in 3 months. Have a healthy 2 year old but two miscarriages before her. Who did you see to get your tests done? Xx

I’ve had 3 in a row and think I’m onto my fourth as having all same symptoms as before. I have a feeling it’s hormone related for me.

I had two in a row before DS1 (conceived three months in a row) back when I was only 31; DS2 was conceived the first month of trying a couple of years later; now 14 weeks pregnant with DS3 (at 41, so much older) and I had about 6 or 7 consecutive false starts / early losses before this pregnancy I was conceiving every cycle but they weren't sticking. I didn't have any investigations as I assumed it was just my body weeding out dodgy eggs by my age you'd expect the majority of them to be problematic so though it was disappointing I wasn't that surprised. If I were younger though I would definitely have had tests in case there was a clear reason for it.

@Ellie1311 I think mine is hormonal too. I have a very short LP and think my endometrium just doesn't get going very well. I'm just on my way to see Lesley Regan and going to ask for endometrial biopsy, karyotyping for us both, and progesterone from after ovulation. Could just be a numbers game but not sure I can keep going through it xx

@ElsieG3m no worries, happy to update. No joy, just more chemicals since last update. We called time on ttc naturally month after month due to my age (39) so we are starting ivf + genetic testing next week to try to eliminate the likely ‘duff eggs’ issue. Hopefully with a carefully chosen normal embryo transferred in and meds to tackle the immune issues we can increase our chances. I’ll let you know if it works!

Testing wise, we went comprehensive and tested for as much as we could. I have autoimmune issues so always suspected that was a factor.

@Berkeys thank you so much for your update. I really wish you all the best with ivf.

I saw Lesley Regan earlier this week and will be having a hysteroscopy on the 24th. She has also sent us both for karyotyping and me for MTHFR/Pai-1 4/5G chromosome testing. I'm filled with dread about the results of karyotyping. She says the treatment wouldn't change and it may not be the reasons for the losses but it's another thing to worry about I guess.

Have you had karyotyping?

@Berkeys ps do you mind my asking about immune issues? Did you have nk cell testing?

Hi there, do you mind me asking in which laboratory did you do your blood tests for MTHFR and PAI-1? I am trying to self-refer myself but can’t seem to find a lab 😔 I have the tests done abroad and have these 2 mutations but wanted to repeat them in London too. How much is consultation with Lesley Regan? Do you think it is really worth it? Thanks for the info!

Hi @K8dferXdder we have had 4 early losses so for us we wanted to leave no stone unturned, but on genetic testing, pai 1 and mthfr, I think you'd need do discuss that with a consultant. I have tested positive for one mutated copy of pai 1 but apparently this mean almost nothing. I'm still waiting for other results. The consultation with Lesley Regan is about £250 but genetic testing was about £800 on top of that. Depending on the number of losses you've had, it may be worth having a work up but you'd really need a doctor to advise you.

Ps 40% of the population had the mthfr variant and they just give a bit more folic acid in pregnancy. It's not as big a deal as the internet would have you believe (according to my consultant haematologist who I spoke to today))