Failed ICSI, high dna fragmentation, consultant wants to try zymot, anyone heard of it?

[Bonnie558]

Hi, we had a successful round of ICSI in 2016 which resulted in our son, since then, we’ve had a failed FET and two failed rounds of ICSI. After going to a new clinic and various tests, my husband has 52% dna fragmentation so it’s a miracle we ever conceived with ICSI. Our consultant has suggested we have Zymot, it’s a special dish to filter the sperm, it’s really new, only came to the UK end of last year I think. Our consultant has said patients in similar positions to ours have got pregnant and had embryos good enough to freeze too! It sounds all too good to be true, just wondering has anyone heard of it/had it? The clinic doesn’t charge anything extra for it. Our consultant seems to think it’s the biggest breakthrough in fertility side ICSI in the ‘90s. Also thought it would be useful info if anyone else is in a similar boat x

This sounds really interesting. We're starting ICSI soon and would love to read more about this.

If they’re not charging you, it’s because it’s still experimental. Nonetheless, in fertility medicine they’re learning new things all the time so it’s definitely worth a try. Could you ask them to split the treatment between the eggs, so some have straightforward ICSI or IMSI (if they still do that?) and some attempt fertilisation using the new method?

Infertility medicine is fascinating from a R&D viewpoint as the experimentation is virtually self-financing and the patient is extremely motivated to achieve both optimum health and the desired outcome - which is not true at all of many medical conditions.

Sorry, I have just Googled and seen it’s a sperm sorting technique prior to attempting ICSI, so similar to IMSI.

IMSI has been discredited by the HFEA, but it worked for us after five previous IVF failures. My husband had 38% DNA fragmentation after a botched varicocele operation in his teens.

Yeah I think I’ll see if they can do IMSI too. Yeah my husband had an undescended testicle that wasn’t fixed properly until he was a teenager. Where did you have IMSI? I really want to find someone who’s had zymot but it’s so new I can’t find anyone!

Lister, with Jonathan Ramsay and James Nicopoullos. I’m so sorry you’re having to go through this, but hopefully it won’t be so bad given you already have your son.

Hello!
We did two rounds of IVF with ICSI in Spain with IVI using Zymot (they call it fertile chip there). It's widely used across several clinics in Spain and it was actually originally recommended to us by a consultant in London who thought it could help us.
There was a lab in spain associated with our clinic that did a test on the sperm before and after passing through the chip. My husband's sperm had 73% single-strand DNA fragmentation and 86% double-strand DNA fragmentation. The chip reduced it the damage to 7% single-strand and 50% double-strand fragmentation. Still not great but hopefully gives us a chance!
We managed to get two embryos (one from each round) - and i think the main limiting factor was my low ovarian reserve.
We cannot get to spain at the moment but are trying to find a clinic in London that does this. Thank you so much for telling us the name of your clinic!

We used Zymot with icsi in the UK, didn’t work out but I think it improved results as pgs testing was better when we used it! If I knew sperm frag was an issue I think it’s definitely worth adding in.

We’re at Zita west, start stimulation some time next week. I’m really pinning a lot of hope on zymot. This is definitely our last round as I feel we’ve tried everything else! X

Hi Bonnie,

My partner and I are in the same boat as you.

Just wondering how your latest round with ZW is coming along?

Hi @riya188. It’s gone sort of ok thank you! In the end we couldn’t have the zymot as the sperm wasn’t motile enough, which I was really upset about as I was counting on it to get more embryos. However we ended up with three embryos which I was pleased with as we’ve never had three blastocysts before. They had to be frozen because my progesterone levels were too high before the egg collection which makes the lining unreceptive. Starting an FET in a few weeks. Zita west have been great, really impressed with the care I’ve received. Are you hoping to have zymot?

Hi Bonnie,

Good news that you’ve got 3 frozen blastocysts!! Yes, we are looking at zymot. We’re early in the process so just trying to figure all of this out!

Hi @Bonnie558,

How did your FET go?
x

Hi Bonnie,

How did your FET go?
x

Hi @riya188, the FET failed unfortunately. Really gutted as it a top grade and thawed well. Just don’t know whether it was me or the embryo. We’ve got two more frozen which we’ll have put in together at some point but can’t face it at the moment! How are you getting on? X

Hi Bonnie, Really sorry to hear that and hope you’ll feel better soon. Hopefully the 2 you have frozen will work out - I’m sure they will!

We start meds in a few days with egg collection around 15th August, very nervous about the whole thing now...

Hi ladies, did anyone else go on to use Zymot since this thread? Just wondering if it can help us before we call it quits. Our 6th round of ISCI just failed and we are wondering if its worth 1 last roll of the dice. Also where does it? Can't find many places offering it.
Thanks

Hi there,
Sorry I cant help you about Zymot as We also want to use it for our next cycle. However, there are a few clinics offer Zymot such as all Care fertility clinic, Ivf London, Aria Clinic
I hope that helps.
I wonder if anyone else use Zymot?

Thanks Linh0706 👍

elizabethmcn how was your experience in Spain for fertilchip?
Have you done a round in the uk? If so how did it compare?
Which clinic did you use? and can I asked how much a round there with Zymot cost?
Sorry for all the questions.
Thanks for your help.