I had IVF/ICSI. How you handle it does depend on your own circumstances/personality/etc but I personally found it much "easier" than the years of trying, and failing, to conceive naturally! It felt good to be doing something that would really help our chances of having a family.
I broke everything down into little chunks, so never really thought about the process as a whole. iykwim. So initially it was hoping that FSH/LH/AMH results were good, then that downregging was OK, then that the stims were OK, that I was responding well, then that egg collection was OK, etc. It helped me get through each little bit without freaking out too much about the whole thing.
Time off wise, I worked as normal right through downregging and stims and then had egg collection on a Tuesday, took the rest of the week as sick leave, had embryo transfer on Sunday, and took the Monday off for good measure (by which time I was bored and desperate for something to distract me from waiting!). I didn't need so much time off after egg collection, but I wanted it so took it.
My clinic also scheduled scans/blood tests for stims early in the morning, so I was usually able to make it into work at my usual time (or a little late).
The injections are fine. They definitely don't hurt but it's a strange thing to do the first couple of times.
Relationship wise, I did go through a period of grieving for not conceiving naturally. This was mainly during the time we were dealing with the fact that ICSI was our best chance at a family. I found it harder than I thought to deal with, but ultimately I think it brought me and DH closer. I think I have a bit of false memory syndrome though, as I thought I made it through ICSI relatively unscathed but DH remembers me doing things like sobbing at random TV shows and being incredibly neurotic!
I did acupuncture and found it really helpful. It definitely helped me relax more, especially doing a session before and after transfer. Other than that, drink lots of water and remember to take your folic acid 
. Oh and I also lurked a lot on the Fertility Friends website - it's a total font of knowledge and even has cycle buddies threads so you can chat to other women going through the same thing as you.
The tww definitely seemed to drag on, but I guess that's true when you're ttc naturally too. I named the embryos so used to chat to them in my head (sounds mad but really helped me at the time!).
Good luck with it!