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Chronic pain

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Medication and weight gain

4 replies

LucieAnn · 17/08/2025 10:21

In October last year, after a 13 year battle to get a diagnosis, I finally got diagnosed with Fibromyalgia. Whilst there is no cure, there is medication I can take to help me get through each day in the least amount of pain possible. I have good days and really bad days. The flare ups come without warning and I constantly have to have painkillers. I have finally found a medication that gives me some what of a 'normal' life. However it causes serious insomnia, this then has a knock on effect of feeling sluggish, brain fog and unable to concentrate. I was put on a sleeping tablet called Promethazine, I take 50mg each night.

Since taking this tablet I do sleep, I don't wake up in pain during the night and my insomnia is almost completely gone. However it comes with a significant downfall. Weight gain, not just a little weight either, I'm averaging around 3lbs per week. I am the heaviest and biggest I have ever been and it's seriously impacting my mental health. I don't recognise myself in the mirror, I hate getting dressed, I hate how I look.
But I find myself in a catch 22 situation, I need to take my pain medication to be able to function and work but I can't sleep when I take them without the sleeping tablet. I've changed my diet, I do exercise but the weight keeps piling on.

Does anyone on here take duloxetine and suffer insomnia side effects? If so, what do you do to help? Are you on sleeping tablets? How do you manage?
Any advice is welcome, I'm at a loss of what to do. I just want to feel happy and comfortable in my clothes and live a life that's not constantly self conscious and critical.

OP posts:
Orangesandlemons82 · 17/08/2025 10:36

Is it definitely the promethazine causing the weight gain? I didn't think that was a common side effect from it?

LucieAnn · 17/08/2025 14:57

Orangesandlemons82 · 17/08/2025 10:36

Is it definitely the promethazine causing the weight gain? I didn't think that was a common side effect from it?

Yeah, I've been on duloxetine for nearly a year and it's only since I started taking promethazine has the weight gain become a problem. On the back of the packet it says persistent use of it causes weight gain

OP posts:
mydaughterisademon · 17/08/2025 16:37

Could you switch to melatonin instead? You can buy it online

LucieAnn · 17/08/2025 17:12

mydaughterisademon · 17/08/2025 16:37

Could you switch to melatonin instead? You can buy it online

I haven't researched that but I will have a look. I am going to speak to a GP when I can't get in to see them so I'll see what they say. All I know is I can't continue taking the promethazine

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