Angelina Jolies cancer

[allthegoodnameshadgone]

Hi

My daughters fathers side carries the gene Angelia Jolie had.

Mine doesn't.

Am worried all day everyday about the chances of this being passed on.

Does anyone have any experience.

Don't k is what else to post.

Has the father been tested? If not I would imagine that would be the first step? Have you discussed with your GP?

It can be passed on as easily as from the mother’s side and doesn’t just impact breast / ovarian cancer but can also impact bowel cancers too. But if you’re thinking about kids then don’t let that dissuade you - any one born with this gene now will have more testing.

We have a daughter already. What's the likelihood?

He will not get tested

Thank you for your replies.

Assuming that it was one of his parents (not both) (and that he is definitely their biological child) then he has a 50:50 chance of inheriting that gene and a 50:50 chance of passing it on. So in theory your dd has a 25% chance of having BRAC1. There is a 70% chance of a woman with the BRCA1 gene developing cancer by the time they are 70.

This is only in theory because if he has inherited the BRAC1 gene then your dd has a 50:50 chance, so without knowing your husband/ daughter's geneotype it is impossible to know. Also even if she has inherited it she might be in the 30% who don't develop cancer because of other protective factors. It is something to discuss with her and for her to seek genetic counselling when older and she can make informed decisions.

Who in his family has the gene, that you know of? You can only get tested (or it's only seen as a significant enough risk) if it's a direct relative who has cancer/the gene.

Should say too that if he hasn't inherited the gene, she will not have it or if he has but she hasn't then her risk reduces to roughly the population risk (marginally lower because BRCA1has been eliminated).

Also, if your daughter is young, even if she has the gene it's not really something that will kick in until well into adulthood. And plenty of cancers are very curable these days, never mind in twenty years with more advances. And if she did have the gene and got cancer it would likely be caught early due to screening and vigilance.

We have a similar gene in our family but it doesn't trouble me. My dad's had cancer three times and his sister twice but they're still here and in good health overall. I figure I'll likely have a period of ill health younger than most of my peers, but I'll likely get better so it doesn't trouble me.

Basically, try not to let it bother you, and just make sure that your daughter is well informed when she's an adult.

When she's older she can request the testing. I think it's unusual for them to offer the testing to a woman whose mother doesn't carry the gene but your daughter could request it anyway I'm sure.

Have you read Talk to the Headscarf? It's a personal account but there could be a lot of useful information about the BRCA1 gene mutation in there.
When she's older, her answers to the tyzer cusack (?) questionnaire might lead to your daughter being monitored more closely.

OP, first you need to understand that everyone has the BRCA1 and 2 genes, everyone. They belong to 65 tumours suppressor genes we have. Some carry a mutation and this protective gene doesn't not work as well.

I have a gene mutation on another tumour suppressor gene called nf1 which is located on the same chromosome of the BRCA gene and have used the enormous amount of research on BRCA1 to prevent cancers and tumours for me as nobody really cares, knows or researches NF1.

There is in Canada, a big research movement which has analysed lifestyle as a factor risk to develop cancer with the BRCA1 mutation. They have looked into why do NOT all the women develop cancer despite having the same mutation, so the mutation puts you at higher risk, is a gun is you want, but what is the trigger that pulls the gun? You can read more about the research here www.ncbi.nlm.nih.gov/pmc/articles/PMC4966818/

In other words, there is far more to it than just carrying a mutation. The first thing you need to do get a referral for a genetic clinic and have your daughter tested. If negative, you can stop worrying, if positive you might want to look at lifestyle factors and adhere to the recommendation.
The LIBRE study is at a second stage, It is yet too early to have results, but more and more, epigenetics seems to be determinant in how a gene can be activated or switched off.