My dh is extremely supportive of my childminding work, despite the fact that it probably dominates a lot of my life/home. It is extremely obvious that there must be small children in the house (I'm awash with buggies, high chairs, toys, and all the associated paperwork, etc.) and, no matter how much clearing up I do on Friday night, it is still pretty much "in your face". Our own children are now adults (in age, perhaps not in sanity), so it is so much more noticeable. My dh also works from home on occasions.
He is brilliant with the children if he's around (making tea), knows all of the children and their parents, and is also my assistant on odd occasions.
He accepts that I love doing this as a job, I make good money (always useful!!), and so he puts up with the downside stuff.
I know an ex-childminder whose dh was not supportive at all (was actively anti) - he would leave the house before any mindees arrived, and have breakfast elsewhere, and wouldn't come back until the last mindee had gone home. She had to ensure that all traces of other children were "hidden away".
That is an extreme, but it has to be said that I think it would be really difficult to successfully childmind well without family support.