Letrozole 2.5mg

[Honeystride]

Hi ! New poster so please be kind. I’m 3 years post BC. I was prescribed Tamoxifen which I took for 2 years & then stopped as the lack of sleep was making QoL awful.
Since then I’ve had an oophorectomy & at my 3 year cancerversary the Onc prescribed AI ‘s - Letrozole 2.5mg.

my question is side effects- I’m one week in and the headache & pins and needles are hard going. Does it calm down at all???

ax

I just had letrozole prescribed today by my oncologist after finishing my last cycle of chemo last week. It’ll take a few weeks for his letter to get to GP I expect. He said I have to take calcium too. My mum was taking it for years after her breast cancer, she also hated the stuff because of the size of it and chalkiness. Really not looking forward to the letrozole. I already have an autoimmune condition that causes joint pain. I am going to go to the gym which I will hate and I am bordering between overweight and obese. I have longstanding issues with impulsive eating that I know I need to tackle. I just hope the Letrozole is ok. I have to take ribociclib too, when my local NHS trust finally signs it off…

For people struggling on Letrozole, I highly recommend switching to Anastrazole. Both are AIs with similar outcomes. Ive been on Anastrazole for nearly 10 years. About a year ago, I asked to switch to letrozole and within 6 weeks I had awful pain in my hips and knees. I decided to switch back to Anastrazole and within a month or two the pain had gone again. The side effects just aren't as harsh.

I’m 4 months in on the Letrozole journey. I’m finding the hot flushes more frequent. Not sure if it’s partly due to the weather.

Aching joints have been manageable and not as bad they were to begin with. I’m weight training, drinking lots of water taking glucosamine and vitamin D. I do try to incorporate exercise and movement into everything I do.

@Dancethroughtherain i don’t think the hot weather helps on letrozole. I’ve found hot flushes more frequently this past few weeks. im similar number of months on it.

im also on Ribocylib now this past month and unfortunately got sepsis after catching the summer cold (had no idea I had sepsis).

it’s all the gift that keeps on giving 😩

@Thirdtimeunlucky2025 Oh that looks like a nasty (but necessary!) medication to be on.

I’ve been watching the Kylie Minogue documentary on Netflix. She talks about her experience with breast cancer. Very moving, loved what she had to say on it, especially ‘you’ve got to remember, with cancer, I was still the same person.’ ‘I remember coming out the other end of it feeling more like myself than ever before’ 😍.

@Thirdtimeunlucky2025 I’ve also increased my oily fish intake. I think I might ask to have my bloods checked again after a few months on Letrozole. I think I should probably be taking a statin.

Does anyone have any experience of breast lymphoedema? Unfortunately this is my radiotherapy gift that keeps on giving.

I’m waiting for a lymphoedema clinic appointment. It’s a bloody nuisance but it’s put me on the breast reconstruction list which is quite nice. I quite fancy a boob job 😂.