Personally I don't find it more difficult but I found breastfeeding exhausting and never slept. Putting a bit of extra energy into washing a few bottles each day is an easy payoff.
I don't know where you've got the 2hr rule from. I wonder if its once formula is made up? I personally wouldn't be using it if its not within the hour.
Bottles with cool boiled water remain sterile until they are used. I redo mine every 12 hours so once in a morning, once in an evening all bottles (6) are washed, steam sterilised and filled with water. Stored in the fridge! It takes about 15 mins if that. 10 of which is in the microwave so can do other things while waiting.
Powder is measured out into formula containers and when we need a bottle we add powder, shake, heat to room temp and give.
If we're going out for a day we take the water and powder separate and do exactly the same thing.
Dd sleeps better on formula, no cluster feeding (9 hrs a night 6-3am became quickly unsustainable with other children in the house) so far has been ok on it.
No faffing about the boob in, boob out, in, out, in, out. I found this more of a faff on than bottles. Can wear anything now without the need for vest tops, nursing clips. Don't spend evening stuck to the sofa, undressed with dd screaming because she's starving and ds missing out on mummy time.
We always keep a bought ready made bottle of formula in the car just incase we get caught short.
As long as your very clean, wash your bottles in hot hot, soapy water well, sterilise properly and don't give old formula, baby has as much chance of being ok as any other.
Something to remember, your nipples aren't sterile, neither is the fist/foot/toys baby will chew on.