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Autoimmune disease

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Does anyone have any insights on my symptoms

23 replies

OdiIsNeverMean · 14/10/2025 13:27

Hello all
I’m recently discharged from hospital and looking for some insights if anyone can share as I had lots of tests but they’re stumped and everything is on the table from leukaemia to autoimmune conditions like Lupus and Sjogren’s. I’ll try to be concise without having to drip feed. I should mention I’m not in the UK so this isn’t under the NHS.

I (39f), am 20 months pp with DS (would love to try for another soon). C-section delivery as high blood pressure, then developed pre-eclampsia when he was born/very shortly after as they struggled to manage my BP in recovery and had to spend 1.5 days in ICU. Difficulty recovery from section, and have diastasis recti (diagnosed only 3 weeks ago). I should also add in case it’s relevant that I am asthmatic, I have spina bifida occulta, scoliosis, have a dust mite allergy and anaphylaxis. It seems to me that I catch infections easily.

In February of this year, I woke up I thought it was the flu however it came on very quickly and improved by the next day. About two weeks later the same thing happened again – quick onset and improved within a day or so. And this recurred every 3 to 4 weeks until the end of June. Things settled over the summer but flared again a few weeks ago.

I have started to refer to these occurrences as “episodes”, and they normally come on in the middle of the night. I wake up quite disorientated and normally freezing cold, and it takes a lot to warm me up. Suddenly I am too warm and then I'm dripping in sweat, often with a temperature of about 39C. I am often very nauseous during this time and have on occasion thrown up. Even when I don’t throw up I often feel a sensation of being very empty in my stomach. I’m often unsteady on my feet, and it seems I sleep in very short periods with broken sleep and strange dreams. I always have shooting pains in my body, particularly hands and legs and I feel as weak as water. I’m completely unable to work or take care of DS when I’m having one of these “episodes” which causes my husband to miss work.

In June I went to the GP a few hours into after the onset of one of these episodes where they took my blood and I received a call the next day (when I was predictably feeling much better) to say that my white blood cell count was very high and the doctor couldn’t understand how I could be feeling better already. I was sent to a medical assessment unit at this time but this proved inconclusive but I did get a diagnosis of rheumatoid arthritis but it was explained to me that this would not be the root cause of these episodes I had most recently the first episode since the end of June and again went to my GP he referred me to an E as a urine sample showed that I had a UTI that I didn't know about.

After a day in A&E where things like Lupus were mentioned and I was started on IV antibiotics for the UTI, I was admitted to a ward where I met with the rheumatology team and also a more general doctor and his team. Nothing conclusive has come from this, though they’ve said the Hematology team are fairly confident it’s not leukemia, and things are pointing more towards an autoimmune condition, as my white blood cells are back to normal within 2 days. I don’t know if there’s any connection, but I’ve become a lot more aware, in the last few months, of aches and pains in my hands and feet primarily, but also my limbs.

Thank you if you’ve made it this far. I have an outpatient appointment tomorrow with the Rheumatology team so I’m trying to be as prepared as possible for this, and I’m looking for any experiences or theories people might be able to share that I can research/bring to this appointment.

OP posts:
Drachuughtty · 14/10/2025 20:22

Sorry I've got no idea but this sounds rotten OP. I hope someone else has some ideas to help. And fingers crossed you get a proper diagnosis.

OdiIsNeverMean · 14/10/2025 20:31

Drachuughtty · 14/10/2025 20:22

Sorry I've got no idea but this sounds rotten OP. I hope someone else has some ideas to help. And fingers crossed you get a proper diagnosis.

Thank you so much. I know that posting here is a bit of a long shot. But I'm really keen to hear of others experiences and potential diagnosis as it may be relevant to me. Thanks again!!

OP posts:
Cocotok · 14/10/2025 20:34

I have an autoimmune condition and whilst not identical I do often (maybe every 2 weeks) have times where I’m certain I’m coming down with something- cold, exhaustion above my usual level of fatigue, aches and often sore glands. I’m also having repeat infections. I have noticed mine is linked to times of extra stress. I think it’s easy to underestimate the effect autoimmune conditions have on the body, my diagnosis is fairly recent so I’m learning as I go.

steamingin · 14/10/2025 20:35

Do you know what bloods they checked for? Was it a full autoimmune panel? And scans- did they do any?

mynameiscalypso · 14/10/2025 20:45

I had a diagnosis of MCAS for a while, triggered by a viral illness. I’m not convinced it was right in my case but it does have all sorts of weird symptoms and connects to autoimmune conditions.

isitmyturn · 14/10/2025 21:43

It sounds rough OP, on top on some serious underlying conditions.
I have rheumatoid arthritis and don't really recognise any of those symptoms other than the hot / cold sweats being a feature of my menopause.

Bluemin · 14/10/2025 23:34

I think you should have a full allergy screening, especially in light of the dust mite allergy. Have yoy had this done? It sounds like an inflammatory response to something.

TheSpottedZebra · 15/10/2025 22:34

How did you get on today?
You mentioned anaphylaxis- what gives you this reaction?

MinnieJumbo · 15/10/2025 22:50

I would also consider MCAS. One of the symptoms I get is feeling like I’m in the first stages of a virus (sore throat, runny nose, temperature, fatigue and headache). That clears up completely after 2/3 days.

This might also account for the waking and sweating at night: histamine dumping.

it can also account for many, many wild and diffuse symptoms over multiple body systems.

OdiIsNeverMean · 03/11/2025 20:05

Cocotok · 14/10/2025 20:34

I have an autoimmune condition and whilst not identical I do often (maybe every 2 weeks) have times where I’m certain I’m coming down with something- cold, exhaustion above my usual level of fatigue, aches and often sore glands. I’m also having repeat infections. I have noticed mine is linked to times of extra stress. I think it’s easy to underestimate the effect autoimmune conditions have on the body, my diagnosis is fairly recent so I’m learning as I go.

Do you mind sharing what your diagnosis is? I'm very much trying to figure out what's going on. All they're working with at the moment is a potential connective tissue disorder.

OP posts:
OdiIsNeverMean · 03/11/2025 20:09

steamingin · 14/10/2025 20:35

Do you know what bloods they checked for? Was it a full autoimmune panel? And scans- did they do any?

Thanks for your questions. Sorry it's taken me a while to come back. Things have been hectic. I've had another flare up and waiting on an unrelated appointment at breast clinic after an incidental finding in my breast during Chest CT.

They said they have checked everything relevant in my blood, full panel I believe. Is there something specific you think I should query?

OP posts:
OdiIsNeverMean · 03/11/2025 20:12

TheSpottedZebra · 15/10/2025 22:34

How did you get on today?
You mentioned anaphylaxis- what gives you this reaction?

Connective tissue disorder is the theory. They doubled my plaquinel and said to come back in 6 months to see if anything has improved or evolved further. Apparently these things take a long time to reveal themselves.

Funnily enough I had a skin prick test in Sept, and hazelnuts are my biggest allergy. I always thought it was peanuts.

OP posts:
OdiIsNeverMean · 03/11/2025 20:13

mynameiscalypso · 14/10/2025 20:45

I had a diagnosis of MCAS for a while, triggered by a viral illness. I’m not convinced it was right in my case but it does have all sorts of weird symptoms and connects to autoimmune conditions.

This was the diagnosis that chat GPT came up with. What kind of doctor/specialism diagnosed this?

OP posts:
OdiIsNeverMean · 03/11/2025 20:13

mynameiscalypso · 14/10/2025 20:45

I had a diagnosis of MCAS for a while, triggered by a viral illness. I’m not convinced it was right in my case but it does have all sorts of weird symptoms and connects to autoimmune conditions.

This was the diagnosis that chat GPT came up with. What kind of doctor/specialism diagnosed this?

OP posts:
mynameiscalypso · 03/11/2025 20:15

@OdiIsNeverMeanMine was diagnosed by my GP. There are a couple of specialists out there as well, both NHS and private.

MaxandMeg · 03/11/2025 20:15

Another vote for MCAS.

OdiIsNeverMean · 03/11/2025 20:15

isitmyturn · 14/10/2025 21:43

It sounds rough OP, on top on some serious underlying conditions.
I have rheumatoid arthritis and don't really recognise any of those symptoms other than the hot / cold sweats being a feature of my menopause.

Oh they did say they don't think I have RA at my appointment a few weeks ago. Connective tissue issue is the working theory at the moment. Could this be explained by perimenopause? I'm 39.

OP posts:
OdiIsNeverMean · 03/11/2025 20:17

mynameiscalypso · 03/11/2025 20:15

@OdiIsNeverMeanMine was diagnosed by my GP. There are a couple of specialists out there as well, both NHS and private.

Interesting. My GP is stumped and just sent me to the Medical Assessment Unit of a private hospital. They got nowhere. I'm not in UK so not under the NHS. But the system isn't vastly different. Maybe I need to explore this further!

OP posts:
OdiIsNeverMean · 03/11/2025 20:24

MinnieJumbo · 15/10/2025 22:50

I would also consider MCAS. One of the symptoms I get is feeling like I’m in the first stages of a virus (sore throat, runny nose, temperature, fatigue and headache). That clears up completely after 2/3 days.

This might also account for the waking and sweating at night: histamine dumping.

it can also account for many, many wild and diffuse symptoms over multiple body systems.

This is really interesting. I just did some googling and some of what I read resonates. Not all though. Can I ask how you got diagnosed?

OP posts:
OdiIsNeverMean · 03/11/2025 20:25

MaxandMeg · 03/11/2025 20:15

Another vote for MCAS.

Interestingly I'm starting to wonder about this now. What makes you think it could be MCAS based on my symptoms?

OP posts:
OdiIsNeverMean · 03/11/2025 20:28

Bluemin · 14/10/2025 23:34

I think you should have a full allergy screening, especially in light of the dust mite allergy. Have yoy had this done? It sounds like an inflammatory response to something.

I had a skin prick test of about 20 things about 2 month ago. Is this a full allergy screen? It definitely does seem to be inflammatory.

OP posts:
triplechoc · 03/11/2025 20:54

Have you been checked for Addison’s disease? A relative has this and took a long time to be diagnosed as her symptoms varied day to day, she was finally diagnosed following a private appointment. The NHS symptom list below lists some of the issues you mention.

Does anyone have any insights on my symptoms
MinnieJumbo · 05/11/2025 23:28

OdiIsNeverMean · 03/11/2025 20:24

This is really interesting. I just did some googling and some of what I read resonates. Not all though. Can I ask how you got diagnosed?

Serum tryptase, is the main test. However, this must be tested during acute flare (1-3hrs after as I understand it) and therefore is notoriously hard to capture through the NHS.

Then, I believe it is a diagnosis of exclusion/symptoms.

I also have congestive tissue issues with BJHS, the MTHFR gene snp which I was advised are related. Hope this helps!

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