Very high risk quadruple result (1 in 3)

[MM222]

Hi ladies,
I am 18 weeks pregnant with my third child. I recently had a quadruple screening test as baby's position at the 12 week scan didn't allow for them to do the nuchal test. The results came back as very high risk for Down's Syndrome (1 in 3). After talking things through with the foetal medicine team, we opted to have an amniocentesis, which we had today.

This pregnancy has been fraught with complications. We had a subchorionic hematoma throughout the first trimester. That was gone by 12 week scan and we were starting to feel more reassured but now there is this.

I am very aware that the quad is not the most sensitive test and its just a screen. Just concerned given how high the risk has come back as. I'm 38, no previous complications in past pregnancies, don't smoke, no family history of chromosomal abnormalities.

Has anyone had experience of having such a high risk result and then gone on to have a normal amniocentesis?

Thanks x

Hi there. Sorry you’re going through this. My screening risk was also 1:3 for T21. You can find my thread in this forum. I opted for both NIPT and amnio. I got my screening results at 14w and had to wait 2 weeks before I was eligible for amnio so I opted for NIPT in the meantime although my GC said the results would come back around the same time. I got a negative NIPT result the Friday before my Tuesday amnio. It took a big weight off and allowed me to relax a bit before the amnio appointment. Im happy to report the amnio came back clear. It’s a horrible time and I feel for you. Hope your results come back clear as well.

Thank you so much for taking the time to reply. It's really great and very reassuring to hear that your results came back all well. The waiting is so horrible. Its good to have some positive stories to hang on to x

I was not able to get measurements or my bloods done at 12 weeks as they booked me in too late and the baby was moving too much. I have had the quadruple test which has come back really high risk 1:4 and I haven’t stopped crying. I have booked my amniocentesis for tomorrow. I was wondering if anyone has had anything similar? x