Would you be concerned with this result?

[mywrencalls]

I had my combined screening results.
1 in 765 for down's
1 in 100,000 for the others.

I'm 37 and NT was 2.0 at 12 weeks 4 days.

I know I'm considered low risk but when you read others who have a much better result, it leaves you with a bit of anxiety

Would you have an NIPT test based on those results?

No.

No I wouldn’t worry. If you think about it, 1 in 100 is still just 1%!

@Teacaketotty Yes when it is put like that it sounds much better. I see people my age with results such as 1 in 10,000 and then start panicking why mine are much lower.

Google is a nightmare sometimes!

Google is a pregnant woman’s worst enemy! My midwife explained it that way to me and I felt so much better.

Your baby's chance of having down syndrome is 0.13%. Or 99.87% chance of not having down syndrome. Don't worry.

I tried to work out the percentage but my Friday brain isn’t working!

Thankyou @KatnissMellark that really puts it into perspective. I wish I had just worked that out the other day and saved myself a few days of worry!

No problem @mywrencalls. I'm pregnant after a few miscarriages and looking at the 'positive' statistic really helps me put things in perspective and calm my anxious thoughts. Best of luck with the rest of your pregnancy.

From a health article for medical professionals about the quad test:

The risk of Down's syndrome varies with maternal age[1]:
1:1,500 at 20 years.
1:800 at 30 years.
1:270 at 35 years.
1:100 at 40 years.
>1:50 at 45 years and over.

So your risk is much lower than average for your age

@toomuchteaandcake I am definitely feeling better about my results, I think I was just comparing too much to other people's results and getting myself stressed out.

I could really do with not paying £500 for an NIPT but if I'm still feeling anxious about it next week, I might just go ahead with it for peace of mind.

The vast difference between my two results unsettled me but I realise the other two conditions are far more rare. Thanks for your reply

It's bizarre though, I've seen threads where people have had the Downs screening, and the result comes back as 1 in 13 or something, and it seems like the baby always turns out affected. Youd still think that a ten percent chance is great odds in your favour, but that there's also no smoke without fire?
What are the factors that change someone's odds from 1 in 100,000 to 1 in 100, assuming they are both the same age etc? I'm like you OP, I would want to know why I was at a higher risk.

But of course at 37 1 in 750 is totally reasonable considering at 45 it's something wild like 1 in 24.

@mywrencalls don't forget your 20 week scan measurements are to look for markers. I got a 1 in 880 results from the test and am not concerned, and I think that if there is anything to worry about that will show at my big scan

No. I’d be reassured. At 38 years old mines come back 1:50.

All my three children were conceived when I was older than you
Interestingly my two sons’ had ridiculously low risks something like 1:3900 and 1:2500 at 38 and 41 respectively
My daughter however - in between the boys - was 1:240

My consultant told me I was “bonkers” for worrying about the risk especially following scans but also that female babies CMS generate higher risks. no idea if that is true!

None of them have any trisomies
Ultimately a NIPT worn give you a definitive answer you would need an amnio for total
Peace of mind.
Unless your scans show soft markers I wouldn’t imagine you’d be offered an amnio but I might be wrong?
If I was you I would not worry but I know it’s easier said than done.

Sorry I should add the risks were for T21 not the other two which were massively lower.

@mywrencalls I am 34 and my NT measurement was 1.8 and bloods were fine apart from my papp-a which was really low. I was classed as high risk. I was sent to a consultant who rescanned next and my NT measurement was 1.3 and he could see nose bone etc and no soft markers. I was offered a harmony blood test which tests the babies DNA, the results came back clear. Apparently my low Papp-a was the cause for my high risk. Do you know what your Papp-a level was? I have said next time I am paying the harmony test at 10 weeks because the screening results worried me sick and they are all just a risk ratio. I don’t think you have anything to worry about but it’s just interesting how they come up with these statistics.

The harmony test isn’t a diagnostic test, it gives a risk ratio (it’s more accurate than the nhs combined screening test but not diagnostic). Only invasive tests such as cvs and amnio can tell you for definite

@LBB2020 You are right it’s not a diagnostic but my risk ratio from the screening was 1:45 and the harmony was less than 1:10000. The results from the screening test worried me sick and I had such an awful week. I was advised to go for the harmony test because the consultant couldn’t see any soft markers on the scan and it’s much more reliable than the nhs screening test.

@LBB2020 I understand it's not diagnostic but as @Missdrifter pointed out, the difference between her NHS result and her NIPT result would have saved her that awful week and I know that a result such as 1 in 10,000 would leave me completely satisfied and comfortable.

So far I am feeling ok with my result, I'm going to talk to my midwife this week and explain my worries. I'm hoping she can give me a breakdown of my results so that I can see how my results were reached.

@mywrencalls i think you will be absolutely fine. Even my high risk had a 97.7% chance that the baby would be fine but I still couldn’t get past the fact that it was high risk. My high risk was my age and low papp-a and actually my midwife told me that the testing of PAPP-a is relatively new and it can be a marker for a chromosome issue or placenta problems but it’s also very likely that it won’t cause any problems at all. I am sure you will feel better once you have spoken to your midwife x

I think you should be very reassured by your results. Mine were 1 in 83 when I was 31 and 1 in 26 in my second pregnancy age 38. Both babies were fine.

Mine are;
Age 33
Hcg 4.5Mom
PAPP-A 0.6Mom
NT 2.1

Nhs risk 1:47

Fetal medicine centre specialist adjusted risk (with added nasal bone tricuspid and ductus venosus soft markers)
= 1:133

Harmony result