We moved from London to the countryside about 2 years ago, with DCs aged 11 and 7. I had been desperate to move back to my county of birth for years, and when DH finally got the opportunity to transfer with his company we did it.I have always worked from home since DCs so made no difference to my working habits.
I have to say I have found it really hard. One of the things I disliked about London was the way that one area merged into the next, there were no clear-cut boundaries between eg suburb A and suburb B. I craved to live in a town/village that had v distinct boundaries. Now that I do I find it really weird. Am in largeish village and find that we see the same people at various different clubs/activities. Feels weird.
Have also found here that people are less willing to chat/welcome outsiders than in London. I am constantly having to make a huge effort to be accepted, and while I admit that is part of moving to a new area, long term residents of the village seem unwilling to make any effort. There are times when I feel exhausted from trying to fit in.
DC1 has had horrible time of being accepted (long story), DC2 better possibly because he is younger. DH (so far) loves it and v happy for having made the move. I really miss my London friends, and London life, and nearness to museums/Kew Gardens/other London attractions.
BUT I don't regret moving, as I feel that if we hadn't taken the opportunity, I would have constantly been wondering what would have happened if we had moved. I think I am a creature of habit, and don't adapt well to change, which I think is part of my problem.
Your children are a lot younger so you will have more opportunities to socialise/meet up with other parents than I have done.
So, hope I have not painted too bleak a picture - just my recent experience!