My understanding is that going out together, partying, represents a significant portion of their interactions in the brief time they knew each other.
Knox seems to have tried to handle discussing her relationship with Kercher in two different ways:
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In Twisted Tale - in some detail, and more matter of factly;
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In Cartwheel, by minimizing her relationship with Kercher (and her murder.
Both of those approaches have drawn criticism, and I think the unavoidable truth is she cannot tell her story without upsetting some people, due to the way it necessarily interacts with Kercher's, and because both prosection theories of the case and the Italian and UK press focus was based on the sex lives and social habits (briefly - both negatively, latterly, pure Kercher and Foxy Knoxy, to manufacture a motive - both versions profoundly harmful to women).
Separately, unless you go down the "minimize Kercher/murder" route - which only works in something like Cartwheel that focuses on life after, particularly motherhood after, trauma - then the question becomes: should Knox "sanitize" Kercher?
I feel like the question itself is partiallty grounded in misogynistic societal views of women's sexuality, and I don't think there would be an equivalent question raised in respect of a portrayal of a male victim.
Misogynistic views of women, and the "perfect victim" concept, are also so central to the story that, were Knox to censor certain aspects of her experiences with Kercher, she'd be upholding and participating in a patriarchal prejudices that oppressed her (and turned Kercher into a trope).
I do continue to struggle with the notion that Knox is blazoning Kercher's sex life, given the extent of ink spilled about it in the past - including in far more specific detail than I can imagine a show screened on ITV could ever go into (and would be hard to justify inclusion given its outside of Knox's direct experience).
I do think it's worth raising that Knox has talked extensively about the emotional and creative difficulties of portraying Meredith Kercher in Twisted Tale, and the burden of trying to honor her. Knox describes trying to humanize her and portray her as a vibrant young woman and not a tragic headline or autopsy report.
She also made very clear that Cartwheel (in her view) honored Kercher - and the overwhelming critic consensus is that it is, at very least, respectful (perhaps even to the show's overall detriment).
I think you're conflating Knox's decisions, on what is or not respectful of Kercher, and your disagreement with them, with a lack of care on her part. I view it as a subjective question, as is the question of how well or not it is executed, and philosophically, I personally am far more drawn to Knox's perspective than certain of the views you have expressed.
I know you place a great deal of weight on the feelings of the Kercher family, to the extent that they may even override all other factors. I'm sure most of us are sympathetic to their pain but I don't think it amounts to anything like a moral veto, given the intersection of the stories and the systematic misogyny laid bare (which I feel leaving unchallenged, or ceasing to challenge, is both harmful to women and disrespectful to Kercher - not least given the persistent misinformation).
On categorizing it as a "comedy", I feel as though this is an extension of your assumption of the worst of Knox's motives. The show plainly and obviously involves comedy, but straddles two genres.
You seem quite persuaded that - whether if the content is respectful or even positive - the decision to select the "comedy" category was an insensitive attempt to court controversy and provoke (frankly, I'm skeptical that the reaction would have been different if she'd submitted it as "spoken word", particularly if the jokes remained present).
Personally, I think it far more likely (based on Knox's statements, the clips of her act I've seen and the reactions to it) that she viewed it as more a comedy, but UK critics found that the least successful aspect, and I just dont see any reason to assume bad faith.
I also feel as though, if we want to talk about whether a label applied to a show was inaccurate to an extent that it could imply bad faith (and I'm not saying that it definitively was, vs an emotional gut reaction), Stephanie Kerchers assertion - that it "normalizes and trivializes violence against women" would be worthy of far greater scrutiny.
@ilovelurchers, obvs